Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Ahmed H Ghobashi"'
Publikováno v:
PLoS ONE, Vol 19, Iss 11, p e0313769 (2024)
Epithelial-to-mesenchymal (EMT) transition is one of the best-known examples of tumor cell plasticity. EMT enhances cancer cell metastasis, which is the main cause of colorectal cancer (CRC)-related mortality. Therefore, understanding underlying mole
Externí odkaz:
https://doaj.org/article/eb270a837cdb4fb09ec914bb4aded435
Autor:
Ahmed H. Ghobashi, Truc T. Vuong, Jane W. Kimani, Christopher A. Ladaika, Peter C. Hollenhorst, Heather M. O’Hagan
Publikováno v:
iScience, Vol 26, Iss 9, Pp 107630- (2023)
Summary: Colorectal cancer (CRC) develops in part through the deregulation of different signaling pathways, including activation of the WNT/β-catenin and PI3K/AKT pathways. Additionally, the lysine methyltransferase enhancer of zeste homologue 2 (EZ
Externí odkaz:
https://doaj.org/article/8c89486deec245ebab43998162055371
Autor:
Shruthi Sriramkumar, Riddhi Sood, Thomas D. Huntington, Ahmed H. Ghobashi, Truc T. Vuong, Tara X. Metcalfe, Weini Wang, Kenneth P. Nephew, Heather M. O’Hagan
Publikováno v:
Journal of Translational Medicine, Vol 20, Iss 1, Pp 1-14 (2022)
Abstract Background Platinum based agents—cisplatin and carboplatin in combination with taxanes are used for the treatment of ovarian cancer (OC) patients. However, the majority of OC patients develop recurrent, platinum resistant disease that is u
Externí odkaz:
https://doaj.org/article/85d7608e424a4ee082a8b2bdd7825bec
Autor:
Heather M. O'Hagan, John J. Turchi, Kenneth P. Nephew, Katherine S. Pawelczak, Pamela S. VanderVere-Carozza, Samuel A. Miller, Ahmed H. Ghobashi, Timothy D. Matthews, Shruthi Sriramkumar
RPA inhibition reduces RING1A localization to sites of cisplatin-induced DNA damage
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49b041054b6f93fc455c2155e4854fa6
https://doi.org/10.1158/1541-7786.22526583.v1
https://doi.org/10.1158/1541-7786.22526583.v1
Autor:
Heather M. O'Hagan, John J. Turchi, Kenneth P. Nephew, Katherine S. Pawelczak, Pamela S. VanderVere-Carozza, Samuel A. Miller, Ahmed H. Ghobashi, Timothy D. Matthews, Shruthi Sriramkumar
Platinum resistance is a common occurrence in high-grade serous ovarian cancer and a major cause of ovarian cancer deaths. Platinum agents form DNA cross-links, which activate nucleotide excision repair (NER), Fanconi anemia, and homologous recombina
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4da77b2f2e36ee78d1475a8e32e3ac12
https://doi.org/10.1158/1541-7786.c.6545145.v1
https://doi.org/10.1158/1541-7786.c.6545145.v1
Autor:
John J. Turchi, Timothy D. Matthews, Pamela S. VanderVere-Carozza, Katherine S. Pawelczak, Samuel A. Miller, Shruthi Sriramkumar, Ahmed H. Ghobashi, Kenneth P. Nephew, Heather M. O'Hagan
Publikováno v:
Mol Cancer Res
Platinum resistance is a common occurrence in high-grade serous ovarian cancer and a major cause of ovarian cancer deaths. Platinum agents form DNA cross-links, which activate nucleotide excision repair (NER), Fanconi anemia, and homologous recombina
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31b29d58adecb033cd553f7339052fc6
Autor:
Ahmed H. Ghobashi, Maher A. Kamel
Publikováno v:
Journal of applied genetics. 59(2)
The maintenance of genome integrity is essential for organism survival. Therefore, eukaryotic cells possess many DNA repair mechanisms in response to DNA damage. Acetyltransferase, Tip60, plays a central role in ATM and p53 activation which are invol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23e89bfcb0cad7e82a768efaa604594e
https://pubmed.ncbi.nlm.nih.gov/29549519
https://pubmed.ncbi.nlm.nih.gov/29549519