Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Ahmed F. Khan"'
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract Typical differential single-nucleus gene expression (snRNA-seq) analyses in Alzheimer’s disease (AD) provide fixed snapshots of cellular alterations, making the accurate detection of temporal cell changes challenging. To characterize the d
Externí odkaz:
https://doaj.org/article/0a8695f9924f407dabb198b8d280a168
Autor:
Lazaro M. Sanchez-Rodriguez, Ahmed F. Khan, Quadri Adewale, Gleb Bezgin, Joseph Therriault, Jaime Fernandez-Arias, Stijn Servaes, Nesrine Rahmouni, Cécile Tissot, Jenna Stevenson, Hongxiu Jiang, Xiaoqian Chai, Felix Carbonell, Pedro Rosa-Neto, Yasser Iturria-Medina
Publikováno v:
Frontiers in Aging Neuroscience, Vol 16 (2024)
The molecular mechanisms underlying neuronal dysfunction in Alzheimer’s disease (AD) remain uncharacterized. Here, we identify genes, molecular pathways and cellular components associated with whole-brain dysregulation caused by amyloid-beta (Aβ)
Externí odkaz:
https://doaj.org/article/1657c77c5c334d1eb95796dc2572b831
Autor:
Yasser Iturria-Medina, Félix Carbonell, Atousa Assadi, Quadri Adewale, Ahmed F. Khan, Tobias R. Baumeister, Lazaro Sanchez-Rodriguez
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-20 (2021)
Iturria-Medina et al. demonstrate the validation of NeuroPM-box — an open-access, multi-tool cross-platform software that can characterize multiscale and multifactorial neuropathological mechanisms. Their tool potentially contributes to a better un
Externí odkaz:
https://doaj.org/article/82be0689e13e456c93524cb325ee326b
Autor:
Quadri Adewale, Ahmed F Khan, Felix Carbonell, Yasser Iturria-Medina, Alzheimer's Disease Neuroimaging Initiative
Publikováno v:
eLife, Vol 10 (2021)
Both healthy aging and Alzheimer’s disease (AD) are characterized by concurrent alterations in several biological factors. However, generative brain models of aging and AD are limited in incorporating the measures of these biological factors at dif
Externí odkaz:
https://doaj.org/article/50ab6f8e5f6e41f7a87efcd0923fe990
Publikováno v:
Alzheimer's & Dementia. 18
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f72e4e6f1a11c90575c520b734e0c196
https://doi.org/10.1002/alz.065508
https://doi.org/10.1002/alz.065508
Autor:
Yasser Iturria-Medina, Quadri Adewale, Ahmed F. Khan, Simon Ducharme, Pedro Rosa-Neto, Kieran O’Donnell, Vladislav A. Petyuk, Serge Gauthier, Philip L. De Jager, John Breitner, David A. Bennett
Publikováno v:
Science advances. 8(46)
Alzheimer’s disease (AD) is a heterogeneous disorder with abnormalities in multiple biological domains. In an advanced machine learning analysis of postmortem brain and in vivo blood multi-omics molecular data ( N = 1863), we integrated epigenomic,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7b2d4fc0129c73a2bf97c5b65412ece
https://pubmed.ncbi.nlm.nih.gov/36399579
https://pubmed.ncbi.nlm.nih.gov/36399579
To characterize the dynamic genetic and cellular differences in AD neuropathology, we apply the novel concept of RNA velocity to the study of single-nucleus RNA from the cortex of 60 subjects with varied levels of AD pathology. RNA velocity captures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c9e2ce80c76ad4044a8266201636fc2f
https://doi.org/10.1101/2022.10.31.22281759
https://doi.org/10.1101/2022.10.31.22281759
Autor:
Atousa Assadi, Yasser Iturria-Medina, Lazaro M. Sanchez-Rodriguez, Ahmed F Khan, Felix Carbonell, Quadri Adewale, Tobias R Baumeister
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-20 (2021)
Communications Biology
Communications Biology
Understanding and treating heterogeneous brain disorders requires specialized techniques spanning genetics, proteomics, and neuroimaging. Designed to meet this need, NeuroPM-box is a user-friendly, open-access, multi-tool cross-platform software capa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73f58f97fa6a1d9a6aafd0bfdf54fa1a
https://doaj.org/article/82be0689e13e456c93524cb325ee326b
https://doaj.org/article/82be0689e13e456c93524cb325ee326b
Autor:
Yasser Iturria-Medina, Alzheimer’s Disease Neuroimaging Initiative, Felix Carbonell, Ahmed F Khan, Quadri Adewale
Publikováno v:
eLife
eLife, Vol 10 (2021)
eLife, Vol 10 (2021)
Both healthy aging and Alzheimer’s disease (AD) are characterized by concurrent alterations in several biological factors. However, generative brain models of aging and AD are limited in incorporating the measures of these biological factors at dif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d35883fdc1a0b1a3313aef732d4dcc40
https://doi.org/10.7554/elife.62589
https://doi.org/10.7554/elife.62589