Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Ahmed Elwakiel"'
Autor:
Ahmed Elwakiel, Dheerendra Gupta, Rajiv Rana, Jayakumar Manoharan, Moh’d Mohanad Al-Dabet, Saira Ambreen, Sameen Fatima, Silke Zimmermann, Akash Mathew, Zhiyang Li, Kunal Singh, Anubhuti Gupta, Surinder Pal, Alba Sulaj, Stefan Kopf, Constantin Schwab, Ronny Baber, Robert Geffers, Tom Götze, Bekas Alo, Christina Lamers, Paul Kluge, Georg Kuenze, Shrey Kohli, Thomas Renné, Khurrum Shahzad, Berend Isermann
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract Coagulation factor XII (FXII) conveys various functions as an active protease that promotes thrombosis and inflammation, and as a zymogen via surface receptors like urokinase-type plasminogen activator receptor (uPAR). While plasma levels of
Externí odkaz:
https://doaj.org/article/2ce97d19ca754507a003d6b16a5ab8c0
Autor:
Moh’d Mohanad Al-Dabet, Khurrum Shahzad, Ahmed Elwakiel, Alba Sulaj, Stefan Kopf, Fabian Bock, Ihsan Gadi, Silke Zimmermann, Rajiv Rana, Shruthi Krishnan, Dheerendra Gupta, Jayakumar Manoharan, Sameen Fatima, Sumra Nazir, Constantin Schwab, Ronny Baber, Markus Scholz, Robert Geffers, Peter Rene Mertens, Peter P. Nawroth, John H. Griffin, Maria Keller, Chris Dockendorff, Shrey Kohli, Berend Isermann
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Persistent diabetic complications despite controlled blood glucose levels, known as hyperglycemic memory, remain a poorly understood phenomenon in diabetic kidney disease. Here the authors identify senescence-associated gene p21 as a regulator of hyp
Externí odkaz:
https://doaj.org/article/e0c24968fbe44886ac4eb5d91d955ed8
Autor:
Sameen Fatima, Saira Ambreen, Akash Mathew, Ahmed Elwakiel, Anubhuti Gupta, Kunal Singh, Shruthi Krishnan, Rajiv Rana, Hamzah Khawaja, Dheerendra Gupta, Jayakumar Manoharan, Christian Besler, Ulrich Laufs, Shrey Kohli, Berend Isermann, Khurrum Shahzad
Publikováno v:
Nutrients, Vol 14, Iss 14, p 2786 (2022)
Diabetes mellitus is hallmarked by accelerated atherosclerosis, a major cause of mortality among patients with diabetes. Efficient therapies for diabetes-associated atherosclerosis are absent. Accelerated atherosclerosis in diabetic patients is assoc
Externí odkaz:
https://doaj.org/article/ec503a51966044dc9cec6c79c8332b5d
Autor:
Rajiv Rana, Jayakumar Manoharan, Anubhuti Gupta, Dheerendra Gupta, Ahmed Elwakiel, Hamzah Khawaja, Sameen Fatima, Silke Zimmermann, Kunal Singh, Saira Ambreen, Ihsan Gadi, Ronald Biemann, Shihai Jiang, Khurrum Shahzad, Shrey Kohli, Berend Isermann
Publikováno v:
Nutrients, Vol 14, Iss 15, p 3138 (2022)
Diabetic kidney disease (DKD) is an emerging pandemic, paralleling the worldwide increase in obesity and diabetes mellitus. DKD is now the most frequent cause of end-stage renal disease and is associated with an excessive risk of cardiovascular morbi
Externí odkaz:
https://doaj.org/article/7a6b09045ec2498d80474223e4c38fcd
Autor:
Saira Ambreen, Sameen Fatima, Ahmed Elwakiel, Rajiv Rana, Kunal Singh, Anubhuti Gupta, Dheerendra Gupta, Hamzah Khawaja, Jayakumar Manoharan, Christian Besler, Ulrich Laufs, Shrey Kohli, Berend Isermann, Khurrum Shahzad
Publikováno v:
Nutrients, Vol 14, Iss 10, p 1991 (2022)
Diabetes mellitus, which is largely driven by nutritional and behavioral factors, is characterized by accelerated atherosclerosis with impaired plaque stability. Atherosclerosis and associated complications are the major cause of mortality in diabeti
Externí odkaz:
https://doaj.org/article/9cb05a37a4304026bb0c2631ff857fed
Autor:
Khurrum, Shahzad, Sameen, Fatima, Hamzah, Khawaja, Ahmed, Elwakiel, Ihsan, Gadi, Saira, Ambreen, Silke, Zimmermann, Peter R, Mertens, Ronald, Biemann, Berend, Isermann
Publikováno v:
Kidney International. 102:766-779
Efficient therapies for diabetic kidney disease (DKD), now the leading cause of kidney failure, are lacking. One hallmark of DKD is sterile inflammation (inflammation in absence of microorganisms), but the underlying molecular mechanisms remain poorl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dedcd447cbb0ebf393a3fd1400e6b71
https://doi.org/10.1016/j.kint.2022.06.010
https://doi.org/10.1016/j.kint.2022.06.010
Autor:
silke zimmermann, Akash Mathew, Olga Bondareva, Ahmed Elwakiel, Klarina Waldmann, Shihai Jiang, Rajiv Rana, Kunal Singh, Shrey Kohli, Khurrum Shahzad, Ronald Biemann, Thomas Roskoden, Silke Storsberg, Christian Mawrin, Ute Krügel, Ingo Bechmann, Jürgen Goldschmidt, Bilal Sheikh, Berend Isermann
While cognitive impairment is common in peripheral diseases such as chronic kidney disease (CKD), mechanistic insights and effective therapies are lacking1,2. Organ substitution reverses cognitive impairment, indicating that cognitive impairment driv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::95470d379b457049b48753bc99e42727
https://doi.org/10.21203/rs.3.rs-2511118/v1
https://doi.org/10.21203/rs.3.rs-2511118/v1
Autor:
Richard Klar, Nora Klöting, Peter R. Mertens, Matthias Blüher, Sven Michel, Frank Jaschinski, Ahmed Elwakiel, Sameen Fatima, Peter P. Nawroth, Hamzah Khawaja, Saira Ambreen, Moh'd Mohanad Al-Dabet, Khurrum Shahzad, Berend Isermann, Ihsan Gadi
Publikováno v:
J. Am. Soc. Nephrol. 32, 3066-3079 (2021)
J Am Soc Nephrol
J Am Soc Nephrol
Background: Maladaptive ER stress signaling in diabetic kidney disease (DKD) is linked to increased glomerular and tubular expression of the cell death-promoting transcription factor C/EBP homologous protein (CHOP). We determined whether therapy with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f3315ed850e672d0e0fcc8a0a9775cf
https://doi.org/10.1681/asn.2021040431
https://doi.org/10.1681/asn.2021040431
Autor:
Matthias Ruebner, Rajiv Rana, Berend Isermann, Dheerendra Gupta, Kunal Kumar Singh, Ahmed Elwakiel, Paulina Markmeyer, Franziska Lochmann, Shrey Kohli, Hanna Huebner, Anubhuti Gupta
Publikováno v:
Blood
Excess platelet activation by extracellular vesicles (EVs) results in trophoblast inflammasome activation, interleukin 1β (IL-1β) activation, preeclampsia (PE), and partial embryonic lethality. Embryonic thrombomodulin (TM) deficiency, which causes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35fbde736f56437b3b17103633a2cc18
https://doi.org/10.1182/blood.2020005225
https://doi.org/10.1182/blood.2020005225
Autor:
Silke Zimmermann, Alireza R. Rezaie, Marcus J. Moeller, Sumra Nazir, Liliana Schaefer, Shruthi Krishnan, Shrey Kohli, Ihsan Gadi, Wei Dong, Sanchita Ghosh, Rajiv Rana, Wolfram Ruf, Dheerendra Gupta, Thati Madhusudhan, Jochen Reiser, Stoyan Stoyanov, Hongjie Wang, Jinyang Zeng-Brouwers, Charles T. Esmon, Ronald Biemann, Berend Isermann, Moh'd Mohanad Al-Dabet, Ahmed Elwakiel, Akash Mathew
Publikováno v:
J Am Soc Nephrol
Journal of the American Society of Nephrology 31(8), 1762-1780 (2020). doi:10.1681/ASN.2019111163
Journal of the American Society of Nephrology 31(8), 1762-1780 (2020). doi:10.1681/ASN.2019111163
BACKGROUND: Diabetic nephropathy (dNP), now the leading cause of ESKD, lacks efficient therapies. Coagulation protease–dependent signaling modulates dNP, in part via the G protein–coupled, protease-activated receptors (PARs). Specifically, the cy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8ab745eca9cb5e689ba1bc527af7d47
https://doi.org/10.1681/asn.2019111163
https://doi.org/10.1681/asn.2019111163