Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Ahmed Elgehama"'
Autor:
Wenjie Guo, Shasha Hu, Ahmed Elgehama, Fenli Shao, Ren Ren, Wen Liu, Wenjing Zhang, Xinlei Wang, Renxiang Tan, Qiang Xu, Yang Sun, Ruihua Jiao
Publikováno v:
Journal of Pharmacological Sciences, Vol 129, Iss 2, Pp 101-106 (2015)
In the present study, the effect of Fumigaclavine C, a fungal metabolite, on murine experimental colitis induced by dextran sulfate sodium (DSS) and its possible mechanism were examined in vivo and vitro. Oral administration of Fumigaclavine C dose-d
Externí odkaz:
https://doaj.org/article/4b49ddbcaf8d49f584abda6be487b16c
Autor:
Ahmed Elgehama, Yixuan Wang, Ying Yu, Lin Zhou, Zhixiu Chen, Liwei Wang, Lijun Sun, Jian Gao, Biao Yu, Yan Shen, Qiang Xu
Publikováno v:
Cancer scienceREFERENCES. 114(1)
Small-molecule-induced degradation of mutant Bcr-Abl1 provides a potential approach to overcome Bcr-Abl1 tyrosine kinase inhibitor (TKI)-resistant chronic myeloid leukemia (CML). Our previous study reported that a synthetic steroidal glycoside SBF-1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::698bb5edc140bb7e2decc9bcbfe2030b
https://pubmed.ncbi.nlm.nih.gov/36086954
https://pubmed.ncbi.nlm.nih.gov/36086954
Publikováno v:
Investigational New Drugs. 39:442-457
Prostate cancers are reliant on androgens for growth and survival. Clinicians and researchers are looking for potent treatments for the resistant forms of prostate cancer; however, a handful of small molecules used in the treatment of castration-resi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::73fc48be8163d5e7590020af75e8d7bd
https://doi.org/10.1007/s10637-020-01050-w
https://doi.org/10.1007/s10637-020-01050-w
Autor:
Ahmed Elgehama
Publikováno v:
Journal of Asian natural products research. 24(7)
Ornithogalum caudatum Ait (OCA) is a natural product used in Chinese traditional medicine. The cholestane saponin OSW-1 is isolated from plant OCA and has recently been shown to have potent cytotoxic effects against different types of cancers. The th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b6b62208f260180403f726e9e39cc2c
https://pubmed.ncbi.nlm.nih.gov/34292111
https://pubmed.ncbi.nlm.nih.gov/34292111
Autor:
Tian Tian, Xudong Wu, Juan Pang, Wenwen Xue, Yang Sun, Yixuan Wang, Xue-Feng Wu, Qiang Xu, Yan Shen, Xin Li, Ahmed Elgehama, Hongxia Qiu
Publikováno v:
Toxicology and Applied Pharmacology. 360:249-256
BCR-ABL kinase mutations, accounting for clinical resistance to tyrosine kinase inhibitor (TKI) such as imatinib, frequently occur in acquired resistance or in advanced phases of chronic myeloid leukemia (CML). Emerging evidence implicates a critical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39bbd34ffc8526d2bcb09b511e57aac4
https://doi.org/10.1016/j.taap.2018.09.044
https://doi.org/10.1016/j.taap.2018.09.044
Publikováno v:
Investigational new drugs. 39(2)
Prostate cancers are reliant on androgens for growth and survival. Clinicians and researchers are looking for potent treatments for the resistant forms of prostate cancer; however, a handful of small molecules used in the treatment of castration-resi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::23d759d4c423eabf673f853d4f738c06
https://pubmed.ncbi.nlm.nih.gov/33411211
https://pubmed.ncbi.nlm.nih.gov/33411211
The AR (androgen receptor) is a primary therapeutic target in androgen-dependent prostate cancer. Challenges remain for AR-independent prostate cancer as they exhibit complex cellular signaling in their progression rather than relying on the AR. Curr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::32f9800a857e2fd9796bc9b40059fd6b
https://doi.org/10.22541/au.159665112.27566234
https://doi.org/10.22541/au.159665112.27566234
Autor:
Yuyun Xiong, Xiang Li, Yang Sun, Wenjie Guo, Qiang Xu, Chunhong Jiang, Wen Liu, Ji Geng, Jing Gao, Hongqun Ding, Xiaoling Yang, Ahmed Elgehama
Publikováno v:
Biomedicine & Pharmacotherapy. 97:1032-1039
Alzheimer's disease is a neurodegenerative disorder with Amyloid-β plaques onset, synaptic damage, and cognitive decline. Aβ deposits cause pathological events including oxidative stress, mitochondrial dysfunction, and neuron death. In this study,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2e48fec4a05e44da5c5637047ea4e12
https://doi.org/10.1016/j.biopha.2017.11.039
https://doi.org/10.1016/j.biopha.2017.11.039
Autor:
Yan Shen, Xudong Wu, Zijun Ouyang, Xingqi Wang, Qi Zhang, Yang Sun, Qiang Xu, Xue-Feng Wu, Qianqian Meng, Ahmed Elgehama, Wanshuai Li
Publikováno v:
Biomedicine & Pharmacotherapy. 89:1286-1296
Increased endoplasmic reticulum (ER) stress has emerged as a vital contributor to dysregulated glucose homeostasis, and impaired function of sarco-endoplasmic reticulum Ca2+-ATPase 2b (SERCA2b) is one of the central mechanisms underlying ER stress. I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44ebd28d2dc33112fc7a236d8e7e6d85
https://doi.org/10.1016/j.biopha.2017.03.023
https://doi.org/10.1016/j.biopha.2017.03.023
Autor:
Ahmed Elgehama, Yanhong Gu, Yang Sun, Guohui Zhang, Qiang Xu, Xiang Li, Wenjie Guo, Lele Li, Yan Wang
Publikováno v:
Biomedicinepharmacotherapy = Biomedecinepharmacotherapie. 87
Periplakin (PPL), a member of the plakin protein family, has been reported to be down-expressed in urothelial carcinoma. The role of PPL in human colorectal cancer, however, remains largely unknown. Also little is known about the contribution of PPL
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf6f009c63b6eb99cb49ff0a779a1732
https://pubmed.ncbi.nlm.nih.gov/28068625
https://pubmed.ncbi.nlm.nih.gov/28068625