Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Ahmed Elbediwy"'
Drug Repurposing: Exploring Potential Anti-Cancer Strategies by Targeting Cancer Signalling Pathways
Publikováno v:
Biology, Vol 13, Iss 6, p 386 (2024)
The repurposing of previously clinically approved drugs as an alternative therapeutic approach to treating disease has gained significant attention in recent years. A multitude of studies have demonstrated various and successful therapeutic intervent
Externí odkaz:
https://doaj.org/article/ab06e3a30fa746c986e06f3af32b69b8
Autor:
Mario Aguilar-Aragon, Ahmed Elbediwy, Valentina Foglizzo, Georgina C. Fletcher, Vivian S.W. Li, Barry J. Thompson
Publikováno v:
Cell Reports, Vol 22, Iss 7, Pp 1639-1646 (2018)
Summary: Epithelial cells are polarized along their apical-basal axis by the action of the small GTPase Cdc42, which is known to activate the aPKC kinase at the apical domain. However, loss of aPKC kinase activity was reported to have only mild effec
Externí odkaz:
https://doaj.org/article/eaf4599611d44c6c98975889ba8b5dd6
Autor:
Lucrezia Bruno, Simge Karagil, Almas Mahmood, Ahmed Elbediwy, Michael Stolinski, Francesca E. Mackenzie
Publikováno v:
Cells, Vol 10, Iss 11, p 3144 (2021)
The activation of microglia, the inflammatory cells of the central nervous system (CNS), has been linked to the pathogenesis of Alzheimer’s disease and other neurodegenerative diseases. How microglia sense the changing brain environment, in order t
Externí odkaz:
https://doaj.org/article/34b2987a2de140e5853920b925d2b122
Autor:
Nerea Borreguero-Muñoz, Georgina C Fletcher, Mario Aguilar-Aragon, Ahmed Elbediwy, Zoé I Vincent-Mistiaen, Barry J Thompson
Publikováno v:
PLoS Biology, Vol 17, Iss 10, p e3000509 (2019)
The Hippo signalling pathway restricts cell proliferation in animal tissues by inhibiting Yes-associated protein (YAP or YAP1) and Transcriptional Activator with a PDZ domain (TAZ or WW-domain-containing transcriptional activator [WWTR1]), coactivato
Externí odkaz:
https://doaj.org/article/49700236fbce48088ee3945b33c7f241
Autor:
Clara Sidor, Nerea Borreguero-Munoz, Georgina C Fletcher, Ahmed Elbediwy, Oriane Guillermin, Barry J Thompson
Publikováno v:
eLife, Vol 8 (2019)
Mask family proteins were discovered in Drosophila to promote the activity of the transcriptional coactivator Yorkie (Yki), the sole fly homolog of mammalian YAP (YAP1) and TAZ (WWTR1). The molecular function of Mask, or its mammalian homologs Mask1
Externí odkaz:
https://doaj.org/article/c164dd5a41d141f28cc8676d26edc45c
Autor:
Mathias Cobbaut, Simge Karagil, Lucrezia Bruno, Maria Del Carmen Diaz de la Loza, Francesca E Mackenzie, Michael Stolinski, Ahmed Elbediwy
Publikováno v:
Cells, Vol 9, Iss 1, p 151 (2020)
In order to ascertain their external environment, cells and tissues have the capability to sense and process a variety of stresses, including stretching and compression forces. These mechanical forces, as experienced by cells and tissues, are then co
Externí odkaz:
https://doaj.org/article/3da02ae9e93047a2987d11af70b41553
Autor:
Zoé Vincent-Mistiaen, Ahmed Elbediwy, Hannah Vanyai, Jennifer Cotton, Gordon Stamp, Emma Nye, Bradley Spencer-Dene, Gareth J Thomas, Junhao Mao, Barry Thompson
Publikováno v:
eLife, Vol 7 (2018)
Squamous cell carcinoma (SCC) can progress to malignant metastatic cancer, including an aggressive subtype known as spindle cell carcinoma (spSCC). spSCC formation involves epithelial-to-mesenchymal transition (EMT), yet the molecular basis of this e
Externí odkaz:
https://doaj.org/article/6de980c2e1784fdbabf6b0279c684b74
Autor:
Stephen J Terry, Ahmed Elbediwy, Ceniz Zihni, Andrew R Harris, Maryse Bailly, Guillaume T Charras, Maria S Balda, Karl Matter
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e50188 (2012)
Actinomyosin activity is an important driver of cell locomotion and has been shown to promote collective cell migration of epithelial sheets as well as single cell migration and tumor cell invasion. However, the molecular mechanisms underlying activa
Externí odkaz:
https://doaj.org/article/1ab7cf95323a412fa97309259fa7759c
Autor:
Adrian Mihai-Costea, Nasra Hersi, Lija Abu, Felicia Gunawan, Ellen Coakley, Simon Gould, Ahmed Elbediwy
Publikováno v:
New Directions in the Teaching of Natural Sciences. 18
Social and economic barriers that students face during their studies can impact severely on their attainment and can be due to many factors. This study investigated how different socio-economic factors, with a focus on digital poverty and workspace a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d9fff5f2ea4b2fc886499ca2f3e8d47e
https://doi.org/10.29311/ndtns.v18i1.4120
https://doi.org/10.29311/ndtns.v18i1.4120
Autor:
Francesca E. Mackenzie, Almas Mahmood, Lucrezia Bruno, Ahmed Elbediwy, Simge Karagil, Michael Stolinski
Publikováno v:
Cells
Cells, Vol 10, Iss 3144, p 3144 (2021)
Cells, Vol 10, Iss 3144, p 3144 (2021)
The activation of microglia, the inflammatory cells of the central nervous system (CNS), has been linked to the pathogenesis of Alzheimer’s disease and other neurodegenerative diseases. How microglia sense the changing brain environment, in order t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1a911c540bfe26e63b6e649f240ba47
https://eprints.kingston.ac.uk/id/eprint/50570/6/Bruno-L-50570-VoR.pdf
https://eprints.kingston.ac.uk/id/eprint/50570/6/Bruno-L-50570-VoR.pdf
