Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Ahmed El-Sehemy"'
Autor:
Ahmed El-Sehemy, Valerie A. Wallace
Publikováno v:
Molecular & Cellular Oncology, Vol 7, Iss 4 (2020)
We recently reported a novel role of the atypical Wnt ligand, NORRIN, in mediating the proliferation and stemness of glioblastoma stem cells. Mechanistic and functional analysis revealed context-specific phenotypes in which NORRIN can induce opposite
Externí odkaz:
https://doaj.org/article/0a4ea5f7cd3f4d9a93ea085174d04a44
Autor:
Kenneth Aldape, Valerie A. Wallace, Nicole I. Park, Ahmed El-Sehemy, Katherine J. Rowland, Peter B. Dirks, Lilian Lee, Neno T Pokrajac, Yasin Mamatjan, Hayden J. Selvadurai, Arturo Ortín-Martínez, Nobuhiko Tachibana
Publikováno v:
Journal of Clinical Investigation. 130:3069-3086
Glioblastoma multiforme (GBM) contains a subpopulation of cells, GBM stem cells (GSCs), that maintain the bulk tumor and represent a key therapeutic target. Norrin is a Wnt ligand that binds Frizzled class receptor 4 (FZD4) to activate canonical Wnt
Autor:
Philip E. B. Nickerson, Nobuhiko Tachibana, Parnian Dolati, Suying Lu, Nicole Yan, Rod Bremner, Carol Schuurmans, Arturo Ortín-Martínez, Lacrimioara Comanita, Valerie A. Wallace, Ahmed El-Sehemy, Zhongda C. Liu, Neno T Pokrajac, En Leh Samuel Tsai, Akshay Gurdita
Publikováno v:
EMBO J
The EMBO Journal
The EMBO Journal
Emerging evidence suggests that intracellular molecules and organelles transfer between cells during embryonic development, tissue homeostasis and disease. We and others recently showed that transplanted and host photoreceptors engage in bidirectiona
Autor:
Anjali Balakrishnan, Lata Adnani, Vorapin Chinchalongporn, Lakshmy Vasan, Oleksandr Prokopchuk, Myra Chen, Ahmed El-Sehemy, Thomas Olender, Yacine Touahri, Shiekh Tanveer Ahmad, Rehnuma Islam, Sajeevan Sujanthan, Dawn Zinyk, Lacrimioara Comanita, Boris Kan, Taylor Fleming, Hon Leong, Cindi Morshead, Marjorie Brand, Valerie Wallace, Jennifer Chan, Carol Schuurmans
Oligodendrogliomas are lower-grade, slow-growing gliomas that are ultimately fatal. Although driver mutations are known, the mechanisms underlying their signature slow growth rates are poorly understood. We found evidence for intra-tumoral interactio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::27b0ef9d126c6e1faf6198363b23513d
https://doi.org/10.21203/rs.3.rs-39873/v1
https://doi.org/10.21203/rs.3.rs-39873/v1
Autor:
Ahmed El-Sehemy, Yacine Touahri, Myra J. Chen, Thomas Olender, Carol Schuurmans, Cindi M. Morshead, Taylor Fleming, Jennifer A. Chan, Dawn Zinyk, Sajeevan Sujanthan, Shiekh Tanveer Ahmad, Valerie A. Wallace, Rehnuma Islam, Oleksandr Prokopchuk, Lata Adnani, Vorapin Chinchalongporn, Lacrimioara Comanita, Hon Leong, Marjorie Brand, Lakshmy Vasan, Anjali Balakrishnan, Boris Kan
Oligodendrogliomas are lower-grade, slow-growing gliomas that are ultimately fatal. Although driver mutations are known, the mechanisms underlying their signature slow growth rates are poorly understood. We found evidence for intra-tumoral interactio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::811a924dc60231154e348099bab38ea1
https://doi.org/10.1101/2020.07.14.202200
https://doi.org/10.1101/2020.07.14.202200
Publikováno v:
Nitric Oxide. 54:30-37
Ovarian cancer is the leading cause of death due to gynecologic malignancies worldwide. Current therapy regimens are ineffective to treat advanced ovarian cancers, presenting a need to develop novel therapeutic strategies. Nitric oxide (NO) is a mult
Autor:
Yang Xin Fu, Nidhi Gupta, Ahmed El-Sehemy, Helen Steed, Aly Karsan, Zhihua Xu, Abul K. Azad, Alex C.Y. Chang
Publikováno v:
Cellular Signalling. 25:2780-2787
Nitric oxide (NO) is generated by tumor, stromal and endothelial cells and plays a multifaceted role in tumor biology. Many physiological functions of NO are mediated by soluble guanylyl cyclase (sGC) and NO/sGC signaling has been shown to promote pr
Publikováno v:
Gynecologic Oncology. 130:200-206
Objective Notch3 is implicated in chemoresistance of ovarian cancer, yet the molecular mechanism underlying Notch3-mediated drug resistance remains to be elucidated. Here, we investigated the role of Notch3 in carboplatin-induced apoptosis in ovarian
Autor:
Mohamed Fares, Jingdong Zhang, Hai-Feng Zhang, Peng Wang, Yung-Hsing Huang, Raymond Lai, Abdulraheem Alshareef, Chengsheng Wu, Ahmed El-Sehemy
Publikováno v:
Scientific Reports
Various forms of oncogenic ALK proteins have been identified in various types of human cancers. While Crizotinib, an ALK inhibitor, has been found to be therapeutically useful against a subset of ALK+ tumours, clinical resistance to this drug has bee
Autor:
Alan J. Mears, Adam Baker, Keqin Yan, Sheila Smiley, Valerie Wallace, Catherine Tsilfidis, Stuart Matan-Lithwick, Narsis Daftarian, Carol Schuurmans, Philip E. B. Nickerson, En Leh Samuel Tsai, Yves De Repentigny, Sherry Thurig, Yves Sauve, Lacrimioara Comanita, Jeff Biernaskie, Yacine Touahri, Rajiv Dixit, Rashmi Kothary, Ahmed El-Sehemy, Tooka Aavani
Publikováno v:
Scientific Reports
We report successful retinal cone enrichment and transplantation using a novel cone-GFP reporter mouse line. Using the putative cone photoreceptor-enriched transcript Coiled-Coil Domain Containing 136 (Ccdc136) GFP-trapped allele, we monitored develo