Repurposing FDA-approved sulphonamide carbonic anhydrase inhibitors for treatment of Neisseria gonorrhoeae

Autor: Nader S. Abutaleb, Ahmed E. M. Elhassanny, Alessio Nocentini, Chad S. Hewitt, Ahmed Elkashif, Bruce R. Cooper, Claudiu T. Supuran, Mohamed N. Seleem, Daniel P. Flaherty

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 51-61 (2022)

Neisseria gonorrhoeae is a high-priority pathogen of concern due to the growing prevalence of resistance development against approved antibiotics. Herein, we report the anti-gonococcal activity of ethoxzolamide, the FDA-approved human carbonic anhydr

Externí odkaz: https://doaj.org/article/908f9289255d400d818e259d8b402431

Auranofin exerts antibacterial activity against Neisseria gonorrhoeae in a female mouse model of genital tract infection.

Autor: Ahmed E M Elhassanny, Nader S Abutaleb, Mohamed N Seleem

Publikováno v: PLoS ONE, Vol 17, Iss 4, p e0266764 (2022)

Neisseria gonorrhoeae has been classified by the U.S. Centers for Disease Control and Prevention as an urgent threat due to the rapid development of antibiotic resistance to currently available antibiotics. Therefore, there is an urgent need to find

Externí odkaz: https://doaj.org/article/2c310237b2cd465597b3e2b9f7651098

Structure–Activity Relationship Studies of Acetazolamide-Based Carbonic Anhydrase Inhibitors with Activity against Neisseria gonorrhoeae

Autor: Amanda L. Graboski, Xufeng Cao, Yehia Elgammal, Devon P. Amos, Molly S. Youse, Alessio Nocentini, Nader S. Abutaleb, Anil Kumar Marapaka, Weiwei An, Mohamed N. Seleem, Claudiu T. Supuran, Ahmed E. M. Elhassanny, Katrina J. Holly, Chad S. Hewitt, Daniel P. Flaherty, Jatinder Kaur, Aaron D Krabill, Ahmed Elkashif

Publikováno v: ACS Infectious Diseases. 7:1969-1984

Neisseria gonorrhoeae is an urgent threat to public health in the United States and around the world. Many of the current classes of antibiotics to treat N. gonorrhoeae infection are quickly becoming obsolete due to increased rates of resistance. Thu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::506c99f38b00123de518cee832d6beb7
https://doi.org/10.1021/acsinfecdis.1c00055

Damage-associated molecular pattern (DAMP) activation in melanoma: investigation of the immunogenic activity of 15-deoxy, Δ12,14 prostamide J2

Autor: Daniel A. Ladin, Rene Escobedo, Ahmed E. M. Elhassanny, Rukiyah Van Dross, Colin S. Burns

Publikováno v: Oncotarget

Metastatic melanoma is the most deadly skin neoplasm in the United States. Outcomes for this lethal disease have improved dramatically due to the use of both targeted and immunostimulatory drugs. Immunogenic cell death (ICD) has emerged as another ap

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44e0a0e51f1c3d623dd8d4253931eb9e
http://europepmc.org/articles/PMC7779254

Myeloid ABCG1 Deficiency Enhances Apoptosis and Initiates Efferocytosis in Bronchoalveolar Lavage Cells of Murine Multi-Walled Carbon Nanotube-Induced Granuloma Model

Autor: Eman Soliman, Sophia Bhalla, Ahmed E. M. Elhassanny, Anagha Malur, David Ogburn, Nancy Leffler, Achut G. Malur, Mary Jane Thomassen

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 23, Iss 47, p 47 (2022)
International Journal of Molecular Sciences; Volume 23; Issue 1; Pages: 47

The use of carbon nanotubes has increased in the past few decades. Carbon nanotubes are implicated in the pathogenesis of pulmonary sarcoidosis, a chronic granulomatous inflammatory condition. We developed a murine model of chronic granulomatous infl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::375f455b056cb4d90e605b8a3852f7a3
http://europepmc.org/articles/PMC8744594