Zobrazeno 1 - 10
of 85
pro vyhledávání: '"Ahmed E Hegab"'
Autor:
Ho Namkoong, Makoto Ishii, Hideki Fujii, Kazuma Yagi, Takahiro Asami, Takanori Asakura, Shoji Suzuki, Ahmed E Hegab, Hirofumi Kamata, Sadatomo Tasaka, Koji Atarashi, Nobuhiro Nakamoto, Satoshi Iwata, Kenya Honda, Takanori Kanai, Naoki Hasegawa, Shigeo Koyasu, Tomoko Betsuyaku
Publikováno v:
PLoS Pathogens, Vol 14, Iss 4, p e1006955 (2018)
Macrolides are used to treat various inflammatory diseases owing to their immunomodulatory properties; however, little is known about their precise mechanism of action. In this study, we investigated the functional significance of the expansion of my
Externí odkaz:
https://doaj.org/article/18673713073147ecbc69655bcc50456a
Autor:
Hidehiro Irie, Mari Ozaki, Shotaro Chubachi, Ahmed E. Hegab, Akihiro Tsutsumi, Naofumi Kameyama, Kaori Sakurai, Shingo Nakayama, Shizuko Kagawa, Sachika Wada, Makoto Ishii, Tomoko Betsuyaku, Koichi Fukunaga
Publikováno v:
Respiratory Research, Vol 23, Iss 1, Pp 1-14 (2022)
Abstract Background Cigarette smoke (CS) is associated with chronic obstructive pulmonary disease (COPD) and cancer. However, the underlying pathological mechanisms are not well understood. We recently reported that mice exposed to long-term intermit
Externí odkaz:
https://doaj.org/article/d07522f776094aee8298a74da45b005e
Autor:
Haruko Akatsu, Yuko Shiima, Harumi Gomi, Ahmed E. Hegab, Gen Kobayashi, Toshiyuki Naka, Mieko Ogino
Publikováno v:
BMC Medical Education, Vol 22, Iss 1, Pp 1-9 (2022)
Abstract Background There is no consensus regarding the best time to teach two fundamental pillars of clinical medicine: medical interview and physical examination. We investigated the impacts of teaching the course “Medical Interview and Physical
Externí odkaz:
https://doaj.org/article/b11032d410354e0f935186add3d774a8
Publikováno v:
Stem Cell Research, Vol 33, Iss , Pp 25-35 (2018)
High fat diet (HFD) decreases the lifespan of mice, and is a risk factor for several human diseases. Here, we investigated the effects of a HFD on lung epithelial and stem cells and its interaction with aging. Young and old mice were fed with either
Externí odkaz:
https://doaj.org/article/e95a824909b44fa0a0b7f3c2807b3793
Autor:
Aoi Kuroda, Ahmed E. Hegab, Gao Jingtao, Shuji Yamashita, Nobuyuki Hizawa, Tohru Sakamoto, Hideyasu Yamada, Satoshi Suzuki, Makoto Ishii, Ho Namkoong, Takanori Asakura, Mari Ozaki, Hiroyuki Yasuda, Junko Hamamoto, Shizuko Kagawa, Kenzo Soejima, Tomoko Betsuyaku
Publikováno v:
Respiratory Research, Vol 18, Iss 1, Pp 1-18 (2017)
Abstract Background Aldehyde dehydrogenases (ALDHs) play a major role in detoxification of aldehydes. High expression of ALDHs is a marker for stem cells of many organs including the lungs. A common polymorphism in ALDH2 gene (ALDH2*2) results in ina
Externí odkaz:
https://doaj.org/article/99dab1cd5f8040c1aa344f4e038ef6c9
Data from Upregulation of FGF9 in Lung Adenocarcinoma Transdifferentiation to Small Cell Lung Cancer
Autor:
Koichi Fukunaga, Kenzo Soejima, Tomoko Betsuyaku, David M. Ornitz, Hideo Watanabe, Takashi Kohno, Susumu S. Kobayashi, Ahmed E. Hegab, Yuichiro Hayashi, Katsuya Tsuchihara, Hisao Asamura, Takashi Ohtsuka, Morio Nakamura, Katsuhiko Naoki, Ichiro Kawada, Shinnosuke Ikemura, Mari Ozaki, Takahiro Fukushima, Toshiki Ebisudani, Akifumi Mitsuishi, Taro Shinozaki, Tadashi Manabe, Keita Masuzawa, Tetsuo Tani, Keiko Ohgino, Daisuke Arai, Sachiyo Mimaki, Takashi Kamatani, Shigemichi Hirose, Tae-Jung Kim, Katsura Emoto, Hideki Terai, Junko Hamamoto, Hiroyuki Yasuda, Kota Ishioka
Transdifferentiation of lung adenocarcinoma to small cell lung cancer (SCLC) has been reported in a subset of lung cancer cases that bear EGFR mutations. Several studies have reported the prerequisite role of TP53 and RB1 alterations in transdifferen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ddaf045411379d63d8936cc785bb6772
https://doi.org/10.1158/0008-5472.c.6513297.v1
https://doi.org/10.1158/0008-5472.c.6513297.v1
Autor:
Koichi Fukunaga, Kenzo Soejima, Tomoko Betsuyaku, David M. Ornitz, Hideo Watanabe, Takashi Kohno, Susumu S. Kobayashi, Ahmed E. Hegab, Yuichiro Hayashi, Katsuya Tsuchihara, Hisao Asamura, Takashi Ohtsuka, Morio Nakamura, Katsuhiko Naoki, Ichiro Kawada, Shinnosuke Ikemura, Mari Ozaki, Takahiro Fukushima, Toshiki Ebisudani, Akifumi Mitsuishi, Taro Shinozaki, Tadashi Manabe, Keita Masuzawa, Tetsuo Tani, Keiko Ohgino, Daisuke Arai, Sachiyo Mimaki, Takashi Kamatani, Shigemichi Hirose, Tae-Jung Kim, Katsura Emoto, Hideki Terai, Junko Hamamoto, Hiroyuki Yasuda, Kota Ishioka
Supplementary Table S1. Mutation signature analysis. Supplementary Table S2. Baseline characteristics of the transdifferentiated SCLC patients included in this study. Supplementary Table S3. Intensity of EGFR and Ki67 staining in lung cancer tissues
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f942e0b008c8e2dd7ed6842636f4dcf
https://doi.org/10.1158/0008-5472.22429245
https://doi.org/10.1158/0008-5472.22429245
Autor:
Brigitte N. Gomperts, Lee Goodglick, Steven M. Dubinett, William D. Wallace, Tonya C. Walser, Ignacio I. Wistuba, Luisa M. Solis, Avrum Spira, Marc E. Lenburg, Adam C. Gower, David Chia, Erin L. Maresh, Mohammad Alavi, Steve Horvath, Ahmed E. Hegab, Vi Luan Ha, Jennifer L. Gilbert, Derek W. Nickerson, Vei Mah, Aik T. Ooi
Smoking is the most important known risk factor for the development of lung cancer. Tobacco exposure results in chronic inflammation, tissue injury, and repair. A recent hypothesis argues for a stem/progenitor cell involved in airway epithelial repai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5e27d09eee813b48a6b93a1a2955e956
https://doi.org/10.1158/0008-5472.c.6500286
https://doi.org/10.1158/0008-5472.c.6500286
Autor:
Brigitte N. Gomperts, Lee Goodglick, Steven M. Dubinett, William D. Wallace, Tonya C. Walser, Ignacio I. Wistuba, Luisa M. Solis, Avrum Spira, Marc E. Lenburg, Adam C. Gower, David Chia, Erin L. Maresh, Mohammad Alavi, Steve Horvath, Ahmed E. Hegab, Vi Luan Ha, Jennifer L. Gilbert, Derek W. Nickerson, Vei Mah, Aik T. Ooi
Supplementary Methods, Tables 1-4, Figures 1-6 from Presence of a Putative Tumor-Initiating Progenitor Cell Population Predicts Poor Prognosis in Smokers with Non–Small Cell Lung Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11b4b45cd4e45b59eaf98a2904857b2c
https://doi.org/10.1158/0008-5472.22382682.v1
https://doi.org/10.1158/0008-5472.22382682.v1
Publikováno v:
Stem Cells and Development. 30:908-921
Lung fibrosis is a progressive fatal disease, and the underlying mechanisms remain unclear. These involve a combination of altered fibroblasts, excessive accumulation of extracellular matrix, inflammation, and aberrant activation of epithelial cells.