Deep tissue translocation of graphene oxide sheets in human glioblastoma 3D spheroids and an orthotopic xenograft model

Autor: Thomas Kisby, Katharine Barr, Sandra Vranic, Paul S. Sharp, Yingxian Chen, Maria Stylianou, Kostas Kostarelos, Cyrill Bussy, Ahmed Ceylan, Açelya Yilmazer, Irene de Lázaro, Cansu Gurcan, Hadiseh Taheri, Asuman Özen

Publikováno v: De Lazaro Del Rey, I, Sharp, P, Gurcan, C, Ceylan, A, Stylianou, M, Kisby, T, Chen, Y, Vranic, S, Barr, K, Taheri, H, Ozen, A, Bussy, C, Yilmazer, A & Kostarelos, K 2021, ' Deep tissue translocation of graphene oxide sheets in human glioblastoma 3D spheroids and an orthotopic xenograft model ', Advanced Therapeutics, vol. 4, no. 1, 2000109 . https://doi.org/10.1002/adtp.202000109
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Its anatomical localization, a highly heterogeneous and drug-resistant tumor cell population and a “cold” immune microenvironment, all challenge the treatment of glioblastoma. Nanoscale drug delivery systems, including graphene oxide (GO) flakes,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60be09f25982e1eca4392393b7508797
https://doi.org/10.1002/adtp.202000109