Zobrazeno 1 - 10
of 85
pro vyhledávání: '"Ahmed Bouhss"'
Autor:
Aixiao Li, Ahmed Bouhss, Marie-Jeanne Clément, Cyril Bauvais, J. Paul Taylor, Guillaume Bollot, David Pastré
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
In recent years, RNA has gained traction both as a therapeutic molecule and as a therapeutic target in several human pathologies. In this review, we consider the approach of targeting RNA using small molecules for both research and therapeutic purpos
Externí odkaz:
https://doaj.org/article/22c47e5584934302a02e842601707265
Autor:
Krystel El Hage, Nicolas Babault, Olek Maciejak, Bénédicte Desforges, Pierrick Craveur, Emilie Steiner, Juan Carlos Rengifo-Gonzalez, Hélène Henrie, Marie-Jeanne Clement, Vandana Joshi, Ahmed Bouhss, Liya Wang, Cyril Bauvais, David Pastré
Publikováno v:
eLife, Vol 12 (2023)
RNA-protein interactions (RPIs) are promising targets for developing new molecules of therapeutic interest. Nevertheless, challenges arise from the lack of methods and feedback between computational and experimental techniques during the drug discove
Externí odkaz:
https://doaj.org/article/fba7b44d6c2f4d60b2a3433ce6ea930d
Autor:
Anastasiia Samsonova, Krystel El Hage, Bénédicte Desforges, Vandana Joshi, Marie-Jeanne Clément, Guillaume Lambert, Hélène Henrie, Nicolas Babault, Pierrick Craveur, Rachid C. Maroun, Emilie Steiner, Ahmed Bouhss, Alexandre Maucuer, Dmitry N. Lyabin, Lev P. Ovchinnikov, Loic Hamon, David Pastré
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-16 (2021)
Samsonova et al. show a cooperative association of Lin28 and YB-1 for their target mRNA through their cold-shock domain, which is a conserved β-barrel structure that binds to single-stranded RNA. This study suggests that the association of Lin28 wit
Externí odkaz:
https://doaj.org/article/15258b4c3a3942419e49124926949c3e
Autor:
Juan Carlos Rengifo-Gonzalez, Krystel El Hage, Marie-Jeanne Clément, Emilie Steiner, Vandana Joshi, Pierrick Craveur, Dominique Durand, David Pastré, Ahmed Bouhss
Publikováno v:
eLife, Vol 10 (2021)
TDP-43 is a nuclear RNA-binding protein that forms neuronal cytoplasmic inclusions in two major neurodegenerative diseases, ALS and FTLD. While the self-assembly of TDP-43 by its structured N-terminal and intrinsically disordered C-terminal domains h
Externí odkaz:
https://doaj.org/article/de0ec8831ecd4f1da1a28a35d038e526
Autor:
Martin Oliver, Laurent Le Corre, Mélanie Poinsot, Michaël Bosco, Hongwei Wan, Ana Amoroso, Bernard Joris, Ahmed Bouhss, Sandrine Calvet-Vitale, Christine Gravier-Pelletier
Publikováno v:
Molecules, Vol 27, Iss 6, p 1769 (2022)
New inhibitors of the bacterial tranferase MraY are described. Their structure is based on an aminoribosyl uridine scaffold, which is known to be important for the biological activity of natural MraY inhibitors. A decyl alkyl chain was introduced ont
Externí odkaz:
https://doaj.org/article/21f58ea949fc468d8947943dab983c17
Autor:
Anastasia S. Singatulina, Loic Hamon, Maria V. Sukhanova, Bénédicte Desforges, Vandana Joshi, Ahmed Bouhss, Olga I. Lavrik, David Pastré
Publikováno v:
Cell Reports, Vol 27, Iss 6, Pp 1809-1821.e5 (2019)
Summary: PARP-1 synthesizes long poly(ADP-ribose) chains (PAR) at DNA damage sites to recruit DNA repair factors. Among proteins relocated on damaged DNA, the RNA-binding protein FUS is one of the most abundant, raising the issue about its involvemen
Externí odkaz:
https://doaj.org/article/3bbc96ff185d4201bd1f307312bfe809
Autor:
Adrien Boes, Jean Michel Brunel, Adeline Derouaux, Frédéric Kerff, Ahmed Bouhss, Thierry Touze, Eefjan Breukink, Mohammed Terrak
Publikováno v:
Antibiotics, Vol 9, Iss 7, p 373 (2020)
Peptidoglycan (PG) is an essential polymer of the bacterial cell wall and a major antibacterial target. Its synthesis requires glycosyltransferase (GTase) and transpeptidase enzymes that, respectively, catalyze glycan chain elongation and their cross
Externí odkaz:
https://doaj.org/article/a8126a6e31d2404a824835bca431e117
Autor:
Ahmad Massarweh, Michael Bosco, Isabelle Chantret, Thibaut Léger, Layla Jamal, David I. Roper, Christopher G. Dowson, Patricia Busca, Ahmed Bouhss, Christine Gravier-Pelletier, Stuart E. H. Moore
Publikováno v:
Molecules, Vol 24, Iss 11, p 2135 (2019)
Mammalian protein N-glycosylation requires the transfer of an oligosaccharide containing 2 residues of N-acetylglucosamine, 9 residues of mannose and 3 residues of glucose (Glc3Man9 GlcNAc2) from Glc3Man9GlcNAc2-diphospho (PP)-dolichol (DLO) onto pro
Externí odkaz:
https://doaj.org/article/1441beec40a04b2694a75d4c8de1380d
Autor:
Guillaume Manat, Meriem El Ghachi, Rodolphe Auger, Karima Baouche, Samir Olatunji, Frédéric Kerff, Thierry Touzé, Dominique Mengin-Lecreulx, Ahmed Bouhss
Publikováno v:
PLoS ONE, Vol 10, Iss 11, p e0142870 (2015)
Several integral membrane proteins exhibiting undecaprenyl-pyrophosphate (C55-PP) phosphatase activity were previously identified in Escherichia coli that belonged to two distinct protein families: the BacA protein, which accounts for 75% of the C55-
Externí odkaz:
https://doaj.org/article/1701164c9a5a47f2961811ce12dcb10e
Autor:
Dimitri Chérier, Sean Giacomucci, Delphine Patin, Ahmed Bouhss, Thierry Touzé, Didier Blanot, Dominique Mengin-Lecreulx, Hélène Barreteau
Publikováno v:
Antibiotics, Vol 5, Iss 4, p 36 (2016)
Colicins are bacterial toxins produced by some Escherichia coli strains. They exhibit either enzymatic or pore-forming activity towards a very limited number of bacterial species, due to the high specificity of their reception and translocation syste
Externí odkaz:
https://doaj.org/article/79520a429a814323a0942fdf2b8309c4