Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Ahmed B. M. Mehany"'
Autor:
Mahmoud G. Abo Al-Hamd, Haytham O. Tawfik, Omeima Abdullah, Koki Yamaguchi, Masaharu Sugiura, Ahmed B. M. Mehany, Mervat H. El-Hamamsy, Tarek F. El-Moselhy
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 38, Iss 1 (2023)
Hexahydroquinoline (HHQ) scaffold was constructed and recruited for development of new series of anticancer agents. Thirty-two new compounds were synthesised where x-ray crystallography was performed to confirm enantiomerism. Thirteen compounds showe
Externí odkaz:
https://doaj.org/article/9056c1dbec114abe9db25e676a2af1f4
Autor:
Amany Belal, Mohamed A. Elanany, Ahmed A. Al-Karmalawy, Ahmed Elkamhawy, Mohammed A. S. Abourehab, Heba I. Ghamry, Ahmed B. M. Mehany
Publikováno v:
Journal of Taibah University for Science, Vol 17, Iss 1 (2023)
New pyrrolidine derivatives with more than 50% structural similarity with captopril were designed to get new captopril mimics with superior potential to act on both peripheral and central ACE. Further optimization was carried out through pharmacophor
Externí odkaz:
https://doaj.org/article/68c4605028e142cd83bd4dc65f796cd8
Autor:
Amany Belal, Mona H. Ibrahim, Wael A. Mahdi, Sultan Alshehri, Hasnaa Ali Ebrahim, Mohammed M. Ghoneim, Mohamed El-Sherbiny, Ahmed B. M. Mehany, Heba I. Ghamry
Publikováno v:
Journal of Plant Interactions, Vol 18, Iss 1 (2023)
ABSTRACTA library of natural sesquiterpene and phenolic compounds from Petasites japonicus are being investigated through different computational techniques to study their ability to target BMP. Lipinski rule, ADMET, molecular docking studies and met
Externí odkaz:
https://doaj.org/article/c2e12da7b50c4d8690992cf2835513dc
Autor:
Reda G. Yousef, Alaa Elwan, Ibraheem M. M. Gobaara, Ahmed B. M. Mehany, Wagdy M. Eldehna, Souad A. El-Metwally, Bshra A. Alsfouk, Eslam B. Elkaeed, Ahmed M. Metwaly, Ibrahim H. Eissa
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 2206-2222 (2022)
New nicotinamide derivatives 6, 7, 10, and 11 were designed and synthesised based on the essential features of the VEGFR-2 inhibitors. Compound 10 revealed the highest anti-proliferative activities with IC50 values of 15.4 and 9.8 µM against HCT-116
Externí odkaz:
https://doaj.org/article/c09df274b94249cb8a1c29016714c3fc
Autor:
Abdallah E. Abdallah, Reda R. Mabrouk, Maged Mohammed Saleh Al Ward, Sally I. Eissa, Eslam B. Elkaeed, Ahmed B. M. Mehany, Mariam A. Abo-Saif, Ola A. El-Feky, Mohamed S. Alesawy, Mohamed Ayman El-Zahabi
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 573-591 (2022)
Based on quinazoline, quinoxaline, and nitrobenzene scaffolds and on pharmacophoric features of VEGFR-2 inhibitors, 17 novel compounds were designed and synthesised. VEGFR-2 IC50 values ranged from 60.00 to 123.85 nM for the new derivatives compared
Externí odkaz:
https://doaj.org/article/3af1c5c676984e4bb4c5c70fd837b96c
Autor:
Reda G. Yousef, Albaraa Ibrahim, Mohamed M. Khalifa, Wagdy M. Eldehna, Ibraheem M. M. Gobaara, Ahmed B. M. Mehany, Eslam B. Elkaeed, Aisha A. Alsfouk, Ahmed M. Metwaly, Ibrahim H. Eissa
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 1389-1403 (2022)
A library of modified VEGFR-2 inhibitors was designed as VEGFR-2 inhibitors. Virtual screening was conducted for the hypothetical library using in silico docking, ADMET, and toxicity studies. Four compounds exhibited high in silico affinity against V
Externí odkaz:
https://doaj.org/article/8d0e025758924bbe9f7388baf0e479e8
Autor:
Mohamed H. Saad, Tarek F. El-Moselhy, Nabaweya S, El-Din, Ahmed B. M. Mehany, Amany Belal, Mohammed A. S. Abourehab, Haytham O. Tawfik, Mervat H. El-Hamamsy
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 2489-2511 (2022)
Two new series of symmetric (1a-h) and asymmetric (2a-l) 1,4-DHP derivatives were designed, synthesised, and evaluated as anticancer agents. In vitro anticancer screening of target compounds via National cancer institute “NCI” revealed that analo
Externí odkaz:
https://doaj.org/article/08c13f6eb467482ba301125ea5211ccd
Autor:
Amany Belal, Nagwa M. Abdel Gawad, Ahmed B. M. Mehany, Mohammed A. S. Abourehab, Hazem Elkady, Ahmed A. Al‐Karmalawy, Ahmed S. Ismael
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 1884-1902 (2022)
A new series of 1H-pyrrole (6a–c, 8a–c), pyrrolo[3,2-d]pyrimidines (9a–c) and pyrrolo[3,2-e][1, 4]diazepines (11a–c) were designed and synthesised. These compounds were designed to have the essential pharmacophoric features of EGFR Inhibitors
Externí odkaz:
https://doaj.org/article/d0010d6e90f24c7cabc2f9be034a65f9
Autor:
Mohamed Hagras, Moshira A. El Deeb, Heba S. A. Elzahabi, Eslam B. Elkaeed, Ahmed B. M. Mehany, Ibrahim H. Eissa
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 640-658 (2021)
Discovering of new anticancer agents with potential activity against tubulin polymerisation is still a promising approach. Colchicine binding site inhibitors are the most relevant anti-tubulin polymerisation agents. Thus, new quinoline derivatives ha
Externí odkaz:
https://doaj.org/article/1b5aa93b573e4bc2a093e3d51380f374
Autor:
Mostafa M. Hegazy, Wael M. Afifi, Ahmed M. Metwaly, Mohamed M. Radwan, Muhamad Abd-Elraouf, Ahmed B. M. Mehany, Eman Ahmed, Shymaa Enany, Shahd Ezzeldin, Adel E. Ibrahim, Sami El Deeb, Ahmad E. Mostafa
Publikováno v:
Molecules, Vol 27, Iss 24, p 8809 (2022)
In our continuous study for some African plants as a source for antitrypanosomally and cytotoxic active drugs, nine different plants belonging to the Crassulaceae family have been selected for the present study. Sedum sieboldii leaves extract showed
Externí odkaz:
https://doaj.org/article/073c82b854d94160855c8f51915d0c06