Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Ahmed Amine Khamlichi"'
Autor:
Audrey Dauba, Emmanuelle Näser, Dylan Andrieux, Michel Cogné, Yves Denizot, Ahmed Amine Khamlichi
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-8 (2024)
Abstract Class switch recombination (CSR) plays an important role in adaptive immune response by enabling mature B cells to replace the initial IgM by another antibody class (IgG, IgE or IgA). CSR is preceded by transcription of the IgH constant gene
Externí odkaz:
https://doaj.org/article/26a02d3d617541f8a06c1cd5091d2815
Autor:
Nicolas Denis-Lagache, Christelle Oblet, Tiffany Marchiol, Audrey Baylet, Ophélie Têteau, Iman Dalloul, Zeinab Dalloul, Lina Zawil, Ophélie Dézé, Jeanne Cook-Moreau, Alexis Saintamand, Hend Boutouil, Ahmed Amine Khamlichi, Claire Carrion, Sophie Péron, Sandrine Le Noir, Brice Laffleur, Michel Cogné
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionIn mature B cells, activation-induced deaminase reshapes Ig genes through somatic hypermutation and class switch recombination of the Ig heavy chain (IgH) locus under control of its 3’ cis-regulatory region (3’RR). The 3’RR is itsel
Externí odkaz:
https://doaj.org/article/138b735a8308469d92f827d4c9644e6a
Autor:
Chloé Oudinet, Xuefei Zhang, Nadine Puget, Nia Kyritsis, Claire Leduc, Fatima-Zohra Braikia, Audrey Dauba, Frederick W. Alt, Ahmed Amine Khamlichi
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Immunoglobulin class switch recombination (CSR) plays an important role in humoral imm\une responses by changing the effector functions of antibodies. CSR occurs between highly repetitive switch (S) sequences located upstream of immunoglobulin consta
Externí odkaz:
https://doaj.org/article/fb9a1a28118c4b5dabf5614e2b7d2067
Autor:
Audrey Dauba, Ahmed Amine Khamlichi
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Immunoglobulin class switch recombination (CSR) plays a crucial role in adaptive immune responses through a change of the effector functions of antibodies and is triggered by T-cell-dependent as well as T-cell-independent antigens. Signals generated
Externí odkaz:
https://doaj.org/article/ecf32adb8c0b4e16ba4485dfcf2abd68
Publikováno v:
PLoS Genetics, Vol 15, Iss 2, p e1007930 (2019)
DNA cytosine methylation is involved in the regulation of gene expression during development and its deregulation is often associated with disease. Mammalian genomes are predominantly methylated at CpG dinucleotides. Unmethylated CpGs are often assoc
Externí odkaz:
https://doaj.org/article/0652176dc22b401e9a0253579a412352
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)
Scientific Reports
Scientific Reports, Nature Publishing Group, 2019, 9 (1), ⟨10.1038/s41598-019-54929-x⟩
Scientific Reports
Scientific Reports, Nature Publishing Group, 2019, 9 (1), ⟨10.1038/s41598-019-54929-x⟩
Class switch recombination (CSR), which targets exclusively the constant region of the immunoglobulin heavy chain (IgH) locus, plays an important role in humoral immunity by generating different antibody effector functions. The IgH constant locus con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb0d94c009ca24a3f6bcebf6a8f74dcb
http://link.springer.com/article/10.1038/s41598-019-54929-x
http://link.springer.com/article/10.1038/s41598-019-54929-x
Publikováno v:
Advances in immunology. 147
Class switch recombination (CSR) plays an important role in humoral immunity by generating antibodies with different effector functions. CSR to a particular antibody isotype is induced by external stimuli, and occurs between highly repetitive switch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::26acf7a61d33eec65ba460656143ec76
https://pubmed.ncbi.nlm.nih.gov/32981636
https://pubmed.ncbi.nlm.nih.gov/32981636
Publikováno v:
Cellular and molecular immunology
Cellular and molecular immunology, Nature Publishing Group/Chinese Society of Immunology, 2020, ⟨10.1038/s41423-020-0430-y⟩
Cell Mol Immunol
Cellular and molecular immunology, Nature Publishing Group/Chinese Society of Immunology, 2020, ⟨10.1038/s41423-020-0430-y⟩
Cell Mol Immunol
International audience; Class switch recombination (CSR) enables activated mature B cells to change immunoglobulin (Ig) isotype expression from IgM to IgG, IgE, or IgA. The process requires activation-induced cytidine deaminase (AID) expression and t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68a6b01761bc7049f8906772c2ec2f2f
https://hal.archives-ouvertes.fr/hal-03096510
https://hal.archives-ouvertes.fr/hal-03096510
Publikováno v:
Nucleic Acids Research
Nucleic Acids Research, Oxford University Press, 2020, 48 (7), pp.3553-3566. ⟨10.1093/nar/gkaa108⟩
Nucleic Acids Research, Oxford University Press, 2020, 48 (7), pp.3553-3566. ⟨10.1093/nar/gkaa108⟩
Developing B cells undergo V(D)J recombination to generate a vast repertoire of Ig molecules. V(D)J recombination is initiated by the RAG1/RAG2 complex in recombination centres (RCs), where gene segments become accessible to the complex. Whether tran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee57fbf4da56767a28a3547ff54eb6a1
https://hal.archives-ouvertes.fr/hal-03428258
https://hal.archives-ouvertes.fr/hal-03428258
Publikováno v:
Advances in Immunology
Advances in Immunology, pp.89-137, 2020, ⟨10.1016/bs.ai.2020.06.003⟩
Advances in Immunology ISBN: 9780128207567
Advances in Immunology, pp.89-137, 2020, ⟨10.1016/bs.ai.2020.06.003⟩
Advances in Immunology ISBN: 9780128207567
Class switch recombination (CSR) plays an important role in humoral immunity by generating antibodies with different effector functions. CSR to a particular antibody isotype is induced by external stimuli, and occurs between highly repetitive switch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::144ea43400412a5a5bcbce0c2c784c26
https://hal.archives-ouvertes.fr/hal-03058984
https://hal.archives-ouvertes.fr/hal-03058984