Characterization of Rat ILCs Reveals ILC2 as the Dominant Intestinal Subset

Autor: Ahmed Abidi, Thomas Laurent, Gaëlle Bériou, Laurence Bouchet-Delbos, Cynthia Fourgeux, Cédric Louvet, Raja Triki-Marrakchi, Jeremie Poschmann, Régis Josien, Jérôme Martin

Publikováno v: Frontiers in Immunology, Vol 11 (2020)

Innate lymphoid cells (ILCs) are tissue-resident lymphocytes that lack antigen-specific receptors and exhibit innate effector functions such as cytokine production that play an important role in immediate responses to pathogens especially at mucosal

Externí odkaz: https://doaj.org/article/119cb11df366454a892ce9190ad0cba5

TH17 cells expressing CD146 are significantly increased in patients with Systemic sclerosis

Autor: Alexandrine Bertaud, Monia Khanfir, Raja Marrakchi, Houman Mh, Aurélie S. Leroyer, Brigitte Granel, Xavier Heim, Marcel Blot-Chabaud, Bilel Neili, Ahmed Abidi, Amira Gabsi, F. Said, Asma Gati, Nathalie Bardin, Haifa Sakhri, Sonia Amri, Akram Dlala

Publikováno v: Scientific Reports
Scientific Reports, Nature Publishing Group, 2019, 9 (1), ⟨10.1038/s41598-019-54132-y⟩
Scientific Reports, 2019, 9 (1), ⟨10.1038/s41598-019-54132-y⟩
Scientific Reports, Vol 9, Iss 1, Pp 1-8 (2019)

International audience; Systemic sclerosis (SSc) is an autoimmune disorder characterized by vascular damage, excessive fibrosis and abnormal T cells immune-regulation. CD146 is an adhesion molecule essentially expressed in the vascular system, but al

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae97be04c151de22ca33dcd52f3b6352
https://hal-amu.archives-ouvertes.fr/hal-02734077

Limited Presence of IL-22 Binding Protein, a Natural IL-22 Inhibitor, Strengthens Psoriatic Skin Inflammation

Autor: Robert Sabat, Jean-Christophe Renauld, Jerome Martin, Régis Josien, Kerstin Wolk, Laure Dumoutier, Lucile Drujont, Georgios Kokolakis, Ahmed Abidi, Gaelle Beriou, Cédric Louvet, E. Witte‐Händel

Publikováno v: Journal of Immunology
Journal of Immunology, Publisher : Baltimore : Williams & Wilkins, c1950-. Latest Publisher : Bethesda, MD : American Association of Immunologists, 2017, 198 (9), pp.3671-3678. ⟨10.4049/jimmunol.1700021⟩
Journal of Immunology, 2017, 198 (9), pp.3671-3678. ⟨10.4049/jimmunol.1700021⟩
Journal of Immunology, Vol. 198, no.9, p. 3671-3678 (May 1,2017)

Psoriasis is a chronic inflammatory disease resulting from dysregulated immune activation associated with a large local secretion of cytokines. Among them, IL-22 largely contributes to epithelial remodeling and inflammation through inhibiting the ter

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46bf1e3a1c9c56fc4a5df6c78988643f
https://www.hal.inserm.fr/inserm-02155881

IL-22BP is produced by eosinophils in human gut and blocks IL-22 protective actions during colitis

Autor: Michèle Heslan, Reynald Thinard, Philippe Hulin, Anne Jarry, Ahmed Abidi, Franck Halary, Ignacio Anegon, Gaelle Beriou, Jean-Christophe Renauld, Régis Josien, Céline Bossard, Arnaud Bourreille, Bernard Lardeux, Jerome Martin, Cédric Jacqueline, Séverine Ménoret

Publikováno v: Mucosal Immunology
Mucosal Immunology, Nature Pub. Group, 2016, 9 (2), pp.539-549. ⟨10.1038/mi.2015.83⟩
Mucosal Immunology, Vol. 9, no. 2, p. 539-549 (2016)
Mucosal Immunology, 2016, 9 (2), pp.539-549. ⟨10.1038/mi.2015.83⟩

International audience; Crohn's disease and ulcerative colitis, the two major forms of inflammatory bowel diseases (IBDs), are characterized by high levels of IL-22 production. Rodent studies revealed that this cytokine is protective during colitis b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a425be33e322e2710bcb743503b39fd
https://www.hal.inserm.fr/inserm-02150949/document

Significant association between IL23R and IL17F polymorphisms and clinical features of colorectal cancer

Autor: A. Mezlini, Yves-Jean Bignon, Nancy Uhrhammer, Amel Benammar Elgaaied, Raja Marrakchi, Ahmed Abidi, Hager Ayari, Imen Medimegh, Ines Omrane, Karim Bougatef, Olfa Baroudi, Nejla Stambouli, Nadia Kourda

Publikováno v: Immunology letters. 158(1-2)

Th17cells are involved in inflammatory and autoimmune diseases. These cells may be involved in pathological processes mainly producing pro-inflammatory cytokines. Recently, it was shown that the IL23/IL17 pathway plays an important role in the develo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::420c76d083acc2055d9964ebb6d501c4
https://pubmed.ncbi.nlm.nih.gov/24440568