Design of Novel Enantiopure Dispirooxindolopyrrolidine-Piperidones as Promising Candidates toward COVID-19: Asymmetric Synthesis, Crystal Structure and In Silico Studies

Autor: Amani Toumi, Sarra Boudriga, Yasmine M. Mandour, Ahmed A. Mekki, Michael Knorr, Carsten Strohmann, Jan-Lukas Kirchhoff, Mansour Sobeh

Publikováno v: Molecules, Vol 27, Iss 12, p 3945 (2022)

Despite the effectiveness of COVID-19 vaccines, there is still an urgent need for discovering new anti-viral drugs to address the awful spread and transmission of the rapidly modifiable virus. In this study, the ability of a small library of enantiom

Externí odkaz: https://doaj.org/article/8f958da32e3847e9a489b04e279f1a55

Anti-inflammatory, antibacterial and antioxidant activities of the medicinal species Atractylis cancellata

Autor: Sara Mouffouk, Chaima Mouffouk, Soumia Mouffouk, Ahmed Hachem Mekki, Abderrahman Moumen Messaoud, Hamada Haba

Publikováno v: Journal of Biological Research - Bollettino della Società Italiana di Biologia Sperimentale.

This research is focused on the estimation of total bioactive contents and the evaluation of in vitro pharmacological activities of crude extracts (petroleum ether, ethyl acetate and n-butanol) obtained from the species Atractylis cancellata. The ant

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::262eb58ee9c8444ee4d68782b078c8a1
https://doi.org/10.4081/jbr.2023.11096

THERAPEUTIC EFFECT OF TWO FLUORIDE VARNISHES INTENSIVE MODE ON WHITE SPOT LESIONS (RANDOMIZED CLINICAL TRIAL)

Autor: Ahmed Ibrahim Mekki, Karin Dowidar, Dalia M. Talaat

Publikováno v: Alexandria Dental Journal.

Background: Fluoride varnish has been used as therapeutic agent for white spot lesions. Bio-active calcium and phosphate was included in the varnish in order to provide better subsurface remineralization. One of the most promising modifications is th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4d9ac1fed1cc6c2bd768559e20f060f6
https://doi.org/10.21608/adjalexu.2020.28735.1063

Fuzzy logic for determination of crack severity in defense applications

Autor: Thomas Reynolds, Arati M. Dixit, Thomas J. Meitzler, Ahmed O. Mekki, Harpreet Singh, Vijay Sharma

Publikováno v: SPIE Proceedings.

Problem of crack detection has attracted the attention of several investigators in the areas like defense, aeronautics, and marine industries. In this paper we suggest fuzzy logic approach for detection of cracks and also deciding about the severity

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e825cb2f24f617e0a1734540c97b2ae8
https://doi.org/10.1117/12.853988

A severe case of PLOD1 -related kyphoscoliotic Ehlers-Danlos syndrome associated with several arterial and venous complications: A case report.

Autor: Foy M; AP-HP, GHU Paris Saclay, Hôpital Raymond Poincaré, Centre de référence des syndromes d'Ehlers-Danlos non vasculaires Garches France., Métay C; AP-HP, Groupe Hospitalier La Pitié-Salpêtrière-Charles Foix, Centre de Génétique Moléculaire et Chromosomique, Unité Fonctionnelle de Cardiogénétique et Myogénétique moléculaire et cellulaire Paris France., Frank M; AP-HP, Hôpital européen Georges Pompidou, Centre de référence des maladies vasculaires rares et service de Génétique, PARCC INSERM UMR970, VASCERN MSA European Reference Centre Paris France., Denarié N; AP-HP, Hôpital européen Georges Pompidou, Centre de référence des maladies vasculaires rares et service de Génétique, PARCC INSERM UMR970, VASCERN MSA European Reference Centre Paris France., Adham S; CHU de Montpellier, Hôpital Saint Eloi, Service de Médecine Vasculaire - Montpellier Montpellier France., Billon C; AP-HP, Hôpital européen Georges Pompidou, Centre de référence des maladies vasculaires rares et service de Génétique, PARCC INSERM UMR970, VASCERN MSA European Reference Centre Paris France., Legrand A; AP-HP, Hôpital européen Georges Pompidou, Centre de référence des maladies vasculaires rares et service de Génétique, PARCC INSERM UMR970, VASCERN MSA European Reference Centre Paris France.; Université de Paris, Faculté de Médecine Paris France., Jeunemaitre X; AP-HP, Hôpital européen Georges Pompidou, Centre de référence des maladies vasculaires rares et service de Génétique, PARCC INSERM UMR970, VASCERN MSA European Reference Centre Paris France.; Université de Paris, Faculté de Médecine Paris France., Gillas F; AP-HP, GHU Paris Saclay, Hôpital Raymond Poincaré, Centre de référence des syndromes d'Ehlers-Danlos non vasculaires Garches France., Gaudon K; AP-HP, Groupe Hospitalier La Pitié-Salpêtrière-Charles Foix, Centre de Génétique Moléculaire et Chromosomique, Unité Fonctionnelle de Cardiogénétique et Myogénétique moléculaire et cellulaire Paris France., De Mazancourt P; AP-HP, GHU Paris Saclay, Hôpital Ambroise Paré, Laboratoire de Biochimie Boulogne Billancourt France., Mekki A; AP-HP, GHU Paris Saclay, Hôpital Raymond Poincaré, DMU Smart Imaging Garches France., Carlier R; AP-HP, GHU Paris Saclay, Hôpital Raymond Poincaré, DMU Smart Imaging, UMR1179 INSERM Garches France., Benistan K; AP-HP, GHU Paris Saclay, Hôpital Raymond Poincaré, Centre de référence des syndromes d'Ehlers-Danlos non vasculaires, UMR1179 INSERM Garches France.

Publikováno v: Clinical case reports [Clin Case Rep] 2023 Feb 27; Vol. 11 (2), pp. e6760. Date of Electronic Publication: 2023 Feb 27 (Print Publication: 2023).