Recent Advances in Photothermal Therapies Against Cancer and the Role of Membrane Transporter Modulators on the Efficacy of This Approach

Autor: Ahmed A. Abdulhussein Al-Ali PhD, Nameer Al Ward MSc, Mohammad A. Obeid PhD, Carsten Uhd Nielsen PhD, Paul A. Mulheran PhD, Mohammed M. Al Qaraghuli PhD

Publikováno v: Technology in Cancer Research & Treatment, Vol 22 (2023)

Recently, much research is focused on the use of photothermal therapy (PTT) as an advanced method to treat various types of cancer. The PTT approach primarily utilizes nanoparticles (NPs) made from metals, carbon, or semiconductors that can convert n

Externí odkaz: https://doaj.org/article/c777213a2cf64e19be65733729514b9c

High-dose etoposide formulations do not saturate intestinal P-glycoprotein:Development, stability, and pharmacokinetics in Sprague-Dawley rats

Autor: Lieve Dillen, René Holm, Dries Versweyveld, Jan Snoeys, Ils Pijpers, An Vermeulen, Carsten Uhd Nielsen, Ahmed A. Abdulhussein Al-Ali, Louis Sandra

Publikováno v: Al-Ali, A A A, Sandra, L, Versweyveld, D, Pijpers, I, Dillen, L, Vermeulen, A, Snoeys, J, Holm, R & Nielsen, C U 2020, ' High-dose etoposide formulations do not saturate intestinal P-glycoprotein : Development, stability, and pharmacokinetics in Sprague-Dawley rats ', International Journal of Pharmaceutics, vol. 583, 119399 . https://doi.org/10.1016/j.ijpharm.2020.119399

It has been suggested that oral absorption of low-permeable P-glycoprotein (P-gp) substrates can be increased through saturation of P-gp. For BCS class IV drug substances, saturating P-gp is challenging due to low aqueous solubility. The present stud

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a66d796a4f9a56e88bc1be5b5f20e881
https://findresearcher.sdu.dk:8443/ws/files/170142161/High_dose_etoposide_formulations_do_not_saturate_1_intestinal.pdf

Nonionic surfactants modulate the transport activity of ATP-binding cassette (ABC) transporters and solute carriers (SLC): Relevance to oral drug absorption

Autor: René Holm, Carsten Uhd Nielsen, Bente Steffansen, Ahmed A. Abdulhussein Al-Ali, Rasmus Blaaholm Nielsen

Publikováno v: Al-Ali, A A A, Nielsen, R B, Steffansen, B, Holm, R & Nielsen, C U 2019, ' Nonionic surfactants modulate the transport activity of ATP-binding cassette (ABC) transporters and solute carriers (SLC) : Relevance to oral drug absorption ', International Journal of Pharmaceutics, vol. 566, pp. 410-433 . https://doi.org/10.1016/j.ijpharm.2019.05.033

Recently, it has become evident that pharmaceutical excipients may interfere with the activity of ATP-binding cassette (ABC) transporters and solute carriers (SLC). The present review aims to provide an overview of surfactants shown to modulate subst

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1516f08a90039d765123cd06c32db3ed
https://pubmed.ncbi.nlm.nih.gov/31125713

Tween 20 increase absorptive digoxin transport in MDCKII-MDR1 cells

Autor: Ahmed A. Abdulhussein Al-Ali, Ali, Farhan H., Mohammed El Khatib, Rene Holm, Bente Steffansen, Carsten Uhd Nielsen

Publikováno v: University of Southern Denmark
Abdulhussein, A A, H. Ali, F, El Khatib, M, Holm, R, Steffansen, B & Nielsen, C U 2016, ' Tween 20 increase absorptive digoxin transport in MDCKII-MDR1 cells ', The Annual Meeting of the Danish Chemical Society, Odense, Danmark, 09/06/2016-09/06/2016 .

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::0f7b4fad45776c95e8cc003d676d20e8
https://portal.findresearcher.sdu.dk/en/publications/0333ae98-3339-4817-bc22-910d58516557