Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Ahmed A Kousba"'
Publikováno v:
Drug Metabolism and Disposition. 35:2242-2251
[7-(2,6-Dichloro-phenyl)-5-methyl-benzo[1,2,4]triazin-3-yl]-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-amine (TG100435) is a novel multi-targeted Src family kinase inhibitor with demonstrated anticancer activity in preclinical species. Potent kinase inhib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d6bc1dfd24324742b024735098dc3325
https://doi.org/10.1124/dmd.107.017384
https://doi.org/10.1124/dmd.107.017384
Autor:
Joel Renick, Jianguo Cao, Michael D. Martin, John Doukas, Ahmed A Kousba, Binqi Zeng, John Hood, Steven Hu, Daniel L. Lohse, Xiyun Yu, Arek Tabak, Glenn Noronha, Shiyin Yee, Richard Soll, Andrew McPherson
Publikováno v:
Drug Metabolism and Disposition. 35:929-936
TG100435 ([7-(2,6-dichloro-phenyl)-5-methyl-benzo[1,2,4]triazin-3-yl]-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-amine) is a novel multitargeted, orally active protein tyrosine kinase inhibitor. The inhibition constants (K(i)) of TG100435 against Src, Lyn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9b6bed385d6162f4cb1f1e10ac6eb826
https://doi.org/10.1124/dmd.106.014290
https://doi.org/10.1124/dmd.106.014290
Publikováno v:
Toxicological Sciences. 95:147-155
Chlorpyrifos and diazinon are two commonly used organophosphorus insecticides (OPs), and their primary mechanism of action involves the inhibition of acetylcholinesterase by their metabolites chlorpyrifos-oxon (CPO) and diazinon-oxon (DZO), respectiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1369966733c7aee2cb9d88139d3cea27
https://doi.org/10.1093/toxsci/kfl123
https://doi.org/10.1093/toxsci/kfl123
Publikováno v:
Toxicology. 220:13-25
Previous studies have indicated that juvenile rats are more susceptible than adults to the acute toxicity from exposure to the organophosphorus insecticide chlorpyrifos (CPF) and age-dependent differences in metabolism and sensitivity to cholinestera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::581ae99c830d4e0a2b36cc0c953a75d8
https://doi.org/10.1016/j.tox.2005.11.011
https://doi.org/10.1016/j.tox.2005.11.011
Autor:
Hong Wu, James A. Campbell, Eric W. Hoppe, Ahmed A. Kousba, Chuck Timchalk, Blandina R. Valenzuela
Publikováno v:
Analytical Letters. 38:939-949
Organophosphorus (OP) insecticides (e.g. chlorpyrifos) are widely used in a variety of applications, and the potential exists for significant occupational and environmental exposures. They have been associated with more occupational poisoning cases t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::70d0dc53f4ee6c97f17a6c7003960b0b
https://doi.org/10.1081/al-200054056
https://doi.org/10.1081/al-200054056
Publikováno v:
NeuroToxicology. 25:1013-1030
Diazinon (DZN) is an organophosphorus pesticide with the possibility for widespread exposures. The toxicological effects of DZN are primarily mediated through the effects of its toxic metabolite, DZN-oxon on acetylcholinesterases, which results in ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a09b3d1803a3783093702f6a14301cd
https://doi.org/10.1016/j.neuro.2004.03.002
https://doi.org/10.1016/j.neuro.2004.03.002
Publikováno v:
Journal of Toxicology and Environmental Health, Part A. 67:635-650
There is a need to develop approaches for assessing risk associated with acute exposures to a broad range of metals and chemical agents and to rapidly determine the potential implications to human health. Noninvasive biomonitoring approaches are bein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5b139a1dd17181ae5bb1cd3196c9f00
https://doi.org/10.1080/15287390490428035
https://doi.org/10.1080/15287390490428035
Autor:
Ved P. Pathak, Chun P. Chow, Shiyin Yee, Michael D. Martin, Binqi Zeng, Hong Zhu, Shu Kachi, John Doukas, Naoyasu Umeda, Andrew McPherson, Dellamary Luis A, Hideo Akiyama, J. Hood, Boris Klebansky, Moorthy S.S. Palanki, Richard M. Fine, Katsutoshi Yokoi, Peter A. Campochiaro, Ahmed A Kousba, Joel Renick, Glenn Noronha, Dan Lohse, Xinshan Kang, Richard M. Soll, Colleen Gritzen, Chi Ching Mak, Steven Hu, Jianguo Cao
Publikováno v:
Journal of medicinal chemistry. 51(6)
Age-related macular degeneration (AMD) is one of the leading causes of loss of vision in the industrialized world. Attenuating the VEGF signal in the eye to treat AMD has been validated clinically. A large body of evidence suggests that inhibitors ta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e60c2e3e531b4630c43bbf6701bffacd
https://pubmed.ncbi.nlm.nih.gov/18311895
https://pubmed.ncbi.nlm.nih.gov/18311895
Publikováno v:
The FASEB Journal. 22
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e31d9e8846d4a7cd953889f62505beae
https://doi.org/10.1096/fasebj.22.1_supplement.920.4
https://doi.org/10.1096/fasebj.22.1_supplement.920.4
Publikováno v:
The FASEB Journal. 22
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1e1dcd6aa57dc987457aac01234db06d
https://doi.org/10.1096/fasebj.22.1_supplement.920.3
https://doi.org/10.1096/fasebj.22.1_supplement.920.3