The PPAR-α selective agonist WY14643 improves lupus nephritis via the downregulation of the RORγT/STAT3 signaling pathway in MRL/lpr mice

Autor: Al-Mazroua, Haneen A., Nadeem, Ahmed, Attia, Sabry M., Bakheet, Saleh A., Ahmad, Ajaz, Ansari, Mushtaq A., Ibrahim, Khalid E., Alomar, Hatun A., Almutairi, Mohammed M., Algarzae, Norah K., Mahmoud, Mohamed A., Hussein, Marwa H., Ahmed, Omer M., Ahmad, Sheikh F.

Publikováno v: In International Immunopharmacology 3 January 2025 145

The PPAR-α selective agonist WY14643 improves lupus nephritis via the downregulation of the RORγT/STAT3 signaling pathway in MRL/lpr mice.

Autor: Al-Mazroua HA; Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia., Nadeem A; Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia., Attia SM; Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia., Bakheet SA; Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia., Ahmad A; Department of Clinical Pharmacy, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia., Ansari MA; Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia., Ibrahim KE; Department of Zoology, College of Science, King Saud University, Riyadh 11451, Saudi Arabia., Alomar HA; Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia., Almutairi MM; Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia., Algarzae NK; Department of Physiology, College of Medicine, King Saud University, Riyadh 11451, Saudi Arabia., Mahmoud MA; Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia., Hussein MH; Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia., Ahmed OM; Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia., Ahmad SF; Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia. Electronic address: fashaikh@ksu.edu.sa.

Publikováno v: International immunopharmacology [Int Immunopharmacol] 2024 Dec 08; Vol. 145, pp. 113787. Date of Electronic Publication: 2024 Dec 08.