Zobrazeno 1 - 10
of 121
pro vyhledávání: '"Ahmad Y. Sheikh"'
Autor:
Matthew D, Solomon, Thomas, Leong, Sue Hee, Sung, Catherine, Lee, J Geoff, Allen, Joseph, Huh, Paul, LaPunzina, Hon, Lee, Duncan, Mason, Vicken, Melikian, Daniel, Pellegrini, David, Scoville, Ahmad Y, Sheikh, Dorinna, Mendoza, Sahar, Naderi, Ann, Sheridan, Xinge, Hu, Wendy, Cirimele, Anne, Gisslow, Sandy, Leung, Kristine, Padilla, Michael, Bloom, Josh, Chung, Adrienne, Topic, Paniz, Vafaei, Robert, Chang, D Craig, Miller, David H, Liang, Alan S, Go, Honora, Hui
Publikováno v:
JAMA cardiology. 7(11)
The risk of adverse events from ascending thoracic aorta aneurysm (TAA) is poorly understood but drives clinical decision-making.To evaluate the association of TAA size with outcomes in nonsyndromic patients in a large non-referral-based health care
Autor:
Chang Wang, Thomas D. Turner, Cai Y. Ma, Christopher M. Pask, Ian Rosbottom, Richard S. Hong, Ahmad Y. Sheikh, Qiuxiang Yin, Kevin J. Roberts
Publikováno v:
CrystEngComm. 25:1782-1791
Solid-state analysis of a new quaternary solid-form of ritonavir: an oxalate salt oxalic acid co-crystal acetone solvate.
Autor:
Andrew J. Souers, Nathaniel D. Catron, Geoff G.Z. Zhang, Xilu Wang, Ahmed A. Suleiman, Deanne Stolarik, Yi Shi, Ahmad Y. Sheikh, Yeshwant D. Sanzgiri, Saul H. Rosenberg, Yu-Ming Pu, Darren C. Phillips, Chang H. Park, Rajeev M. Menon, Kennan C. Marsh, Richard A. Marks, Joel D. Leverson, Yi-Yin Ku, Russell C. Klix, John C. Kalvass, Russell A. Judge, Jianguo Ji, Gary J. Jenkins, Richard Hong, Kaid C. Harper, Keith M. Fournier, Steven W. Elmore, Rohinton Edalji, Shuang Chen, Jie Chen, Orlando F. Bueno, Zhi-Fu Tao, Ahmed Hamed Salem
Since gaining approval for the treatment of chronic lymphocytic leukemia (CLL), the BCL-2 inhibitor venetoclax has transformed the treatment of this and other blood-related cancers. Reflecting the large and hydrophobic BH3-binding groove within BCL-2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f852ee29a9488942fba6fce73ac0eaf
https://doi.org/10.1158/1535-7163.c.6543327.v1
https://doi.org/10.1158/1535-7163.c.6543327.v1
Autor:
Andrew J. Souers, Nathaniel D. Catron, Geoff G.Z. Zhang, Xilu Wang, Ahmed A. Suleiman, Deanne Stolarik, Yi Shi, Ahmad Y. Sheikh, Yeshwant D. Sanzgiri, Saul H. Rosenberg, Yu-Ming Pu, Darren C. Phillips, Chang H. Park, Rajeev M. Menon, Kennan C. Marsh, Richard A. Marks, Joel D. Leverson, Yi-Yin Ku, Russell C. Klix, John C. Kalvass, Russell A. Judge, Jianguo Ji, Gary J. Jenkins, Richard Hong, Kaid C. Harper, Keith M. Fournier, Steven W. Elmore, Rohinton Edalji, Shuang Chen, Jie Chen, Orlando F. Bueno, Zhi-Fu Tao, Ahmed Hamed Salem
1. Measured pKa values of ABBV-167 (Table S1. Ionization constants of ABBV-167) 2. Preparation of ABBV-167 on large scale (Scheme S1: Synopsis of GMP synthesis of ABBV-167) 3. Preparation of clinical ABBV-167 drug supply 4. Animal pharmacokinetics (T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b82ad084c554229baf59a8bada6e495
https://doi.org/10.1158/1535-7163.22522290
https://doi.org/10.1158/1535-7163.22522290
Autor:
Rajni Miglani Bhardwaj, Raimundo Ho, Yue Gui, Paul Brackemeyer, Gabriela Schneider-Rauber, Fredrik L. Nordstrom, Ahmad Y. Sheikh
Publikováno v:
Crystal Growth & Design. 22:4250-4259
Autor:
Shuang Chen, Yi Gao, Xiaochun Lou, Rodger F. Henry, DeAnne F. Stolarik, Maya P. Lipert, Ahmad Y. Sheikh, Geoff G. Z. Zhang
Publikováno v:
Molecular Pharmaceutics. 19:2367-2379
Dasabuvir is a non-nucleoside polymerase inhibitor for the treatment of hepatitis C virus (HCV) infection. It is an extremely weak diacidic drug (p
Autor:
Richard S. Hong, Rajni Miglani Bhardwaj, Rodger Henry, Alessandra Mattei, Moiz Diwan, Albert Thomas, Gerald D. Danzer, Ahmad Y. Sheikh
Publikováno v:
Crystal Growth & Design. 22:726-737
Autor:
David A. Degoey, Alessandra Mattei, Rodger F. Henry, Gabriela Schneider-Rauber, Moiz Diwan, Ahmad Y. Sheikh, Kenneth M. Engstrom, Erin Jordan, Nathan S. Abraham, Richard S. Hong, Vivian Juarez, Rajni Miglani Bhardwaj, Charles W. Hutchins, Yi Gao
Publikováno v:
Journal of the American Chemical Society. 143:17479-17491
Direct-acting antiviral regimens have transformed therapeutic management of hepatitis C across all prevalent genotypes. Most of the chemical matter in these regimens comprises molecules well outside the traditional drug development chemical space and
Publikováno v:
Proceedings of the National Academy of Sciences. 119
Predictions of the structures of stoichiometric, fractional, or nonstoichiometric hydrates of organic molecular crystals are immensely challenging due to the extensive search space of different water contents, host molecular placements throughout the
Autor:
Alessandra Mattei, Richard S. Hong, Hanno Dietrich, Dzmitry Firaha, Julian Helfferich, Yifei Michelle Liu, Kiran Sasikumar, Nathan S. Abraham, Rajni Miglani Bhardwaj, Marcus A. Neumann, Ahmad Y. Sheikh
Publikováno v:
Journal of chemical theory and computation. 18(9)
Crystal structure prediction (CSP) has been historically used to complement experimental solid form screening and applied to individual molecules in drug development. The fast development of algorithms and computing resources offers the opportunity t