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Induced pluripotent stem cell modelling of HLHS underlines the contribution of dysfunctional NOTCH signalling to impaired cardiogenesis.

Autor: Yang C; Institute of Genetic Medicine, Newcastle University, Newcastle, UK., Xu Y; Institute of Genetic Medicine, Newcastle University, Newcastle, UK., Yu M; Institute of Genetic Medicine, Newcastle University, Newcastle, UK., Lee D; Institute of Genetic Medicine, Newcastle University, Newcastle, UK., Alharti S; Princess Al Jawhara Al-Brahim Center of Excellence in Research of Hereditary Disorders, King Abdulaziz University, Saudi Arabia., Hellen N; NHLI, Faculty of Medicine, Imperial College London, London, UK., Ahmad Shaik N; Princess Al Jawhara Al-Brahim Center of Excellence in Research of Hereditary Disorders, King Abdulaziz University, Saudi Arabia., Banaganapalli B; Princess Al Jawhara Al-Brahim Center of Excellence in Research of Hereditary Disorders, King Abdulaziz University, Saudi Arabia., Sheikh Ali Mohamoud H; Princess Al Jawhara Al-Brahim Center of Excellence in Research of Hereditary Disorders, King Abdulaziz University, Saudi Arabia., Elango R; Princess Al Jawhara Al-Brahim Center of Excellence in Research of Hereditary Disorders, King Abdulaziz University, Saudi Arabia., Przyborski S; Department of Bioscience, Durham University, Durham, UK., Tenin G; Division of Cardiovascular Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK., Williams S; Division of Cardiovascular Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK., O'Sullivan J; The Newcastle upon Tyne NHS Hospital, UK., Al-Radi OO; Department of Surgery, King Abdulaziz University, Saudi Arabia., Atta J; Department of Surgery, King Abdulaziz University, Saudi Arabia., Harding SE; NHLI, Faculty of Medicine, Imperial College London, London, UK., Keavney B; Division of Cardiovascular Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.; Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK., Lako M; Institute of Genetic Medicine, Newcastle University, Newcastle, UK., Armstrong L; Institute of Genetic Medicine, Newcastle University, Newcastle, UK.

Publikováno v: Human molecular genetics [Hum Mol Genet] 2017 Aug 15; Vol. 26 (16), pp. 3031-3045.