Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Ahmad R. Shebib"'
Publikováno v:
Frontiers in Immunology, Vol 4 (2013)
Endothelial dysfunction is a characteristic feature in diabetes that contributes to the development of vascular disease. Recently, arginase has been implicated in triggering endothelial dysfunction in diabetic patients and animals by competing with e
Externí odkaz:
https://doaj.org/article/8f1c9f27c918464199e01ca06a18b616
Autor:
Kelly J. Peyton, Ahmad R. Shebib, Mohammad A. Azam, Xiao-ming eLiu, David A. Tulis, William eDurante
Publikováno v:
Frontiers in Pharmacology, Vol 3 (2012)
Bilirubin is a heme metabolite generated by the concerted action of the enzymes heme oxygenase and biliverdin reductase. Although long considered a toxic byproduct of heme catabolism, recent preclinical and clinical studies indicate the bilirubin exe
Externí odkaz:
https://doaj.org/article/f086d308c80d4a40be59db1b283dd9d3
Autor:
Robert A. Johnson, Xiao-ming Liu, Kelly J. Peyton, Ahmad R. Shebib, William Durante, Fruzsina K Johnson
Publikováno v:
Amino Acids. 50:747-754
This study investigated the temporal activation of arginase in obese Zucker rats (ZR) and determined if arginase inhibition prevents the development of hypertension and improves insulin resistance in these animals. Arginase activity, plasma arginine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28f194c721d01790667ffe4b10b44df5
https://doi.org/10.1007/s00726-018-2567-x
https://doi.org/10.1007/s00726-018-2567-x
Autor:
Robert A. Johnson, Mohammed A. Azam, Kelly J. Peyton, Ahmad R. Shebib, William Durante, Fruzsina K. Johnson, Xiao-ming Liu
Publikováno v:
Obesity. 23:383-390
Objective This study investigated whether arginase contributes to endothelial dysfunction and hypertension in obese rats. Methods Endothelial function and arginase expression were examined in skeletal muscle arterioles from lean and obese Zucker rats
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c70911d92b9913b86389d52c99b39050
https://doi.org/10.1002/oby.20969
https://doi.org/10.1002/oby.20969
Autor:
William Durante, Mohammed A. Azam, Robert A. Johnson, Kelly J. Peyton, Ahmad R. Shebib, Fruzsina K. Johnson, Xiao-ming Liu
Publikováno v:
The FASEB Journal. 29
Obesity is a major risk factor for the development of hypertension. While endothelial dysfunction (ED) has been implicated in obesity-related hypertension, the mechanisms underlying this defect are...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8d6fa8df4c9e08d82f614b01961fc18f
https://doi.org/10.1096/fasebj.29.1_supplement.805.3
https://doi.org/10.1096/fasebj.29.1_supplement.805.3
Publikováno v:
Frontiers in Immunology, Vol 4 (2013)
Frontiers in Immunology
Frontiers in Immunology
Endothelial dysfunction is a characteristic feature in diabetes that contributes to the development of vascular disease. Recently, arginase has been implicated in triggering endothelial dysfunction in diabetic patients and animals by competing with e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3128f608db02d8405d778a2f60b5e6f2
Autor:
David A. Tulis, William Durante, Kelly J. Peyton, Ahmad R. Shebib, Mohammad A. Azam, Xiao-ming Liu
Publikováno v:
Frontiers in Pharmacology, Vol 3 (2012)
Frontiers in Pharmacology
Frontiers in Pharmacology
Bilirubin is a heme metabolite generated by the concerted action of the enzymes heme oxygenase and biliverdin reductase. Although long considered a toxic byproduct of heme catabolism, recent preclinical and clinical studies indicate the bilirubin exe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c14fd8f7f7f4147dd7826a9da6644201
http://journal.frontiersin.org/Journal/10.3389/fphar.2012.00048/full
http://journal.frontiersin.org/Journal/10.3389/fphar.2012.00048/full
Autor:
Kelly J. Peyton, Ahmad R. Shebib, Benjamin Yates, Yajie Yu, William Durante, Xiao-ming Liu, Hong Wang
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 338(2)
6-[4-(2-Piperidin-1-yl-ethoxy)-phenyl]-3-pyridin-4-yl-pyrazolo[1,5-a] pyrimidine (compound C) is a cell-permeable pyrrazolopyrimidine derivative that acts as a potent inhibitor of AMP-activated protein kinase (AMPK). Although compound C is often used
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f040606298cb66cde403482b2000937
https://pubmed.ncbi.nlm.nih.gov/21566210
https://pubmed.ncbi.nlm.nih.gov/21566210
Publikováno v:
Biochemical pharmacology. 82(4)
We recently identified adenosine monophosphate-activated protein kinase (AMPK) as a novel inducer of heme oxygenase-1 (HO-1) and surprisingly found that compound C (6-[4-(2-piperidin-1-yl-ethoxy)-phenyl]3-pyridin-4-yl-pyrazolo[1,5-a] pyrimidine), a c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::176e66a3030942512e7c4eb8e294b792
https://pubmed.ncbi.nlm.nih.gov/21635873
https://pubmed.ncbi.nlm.nih.gov/21635873
Autor:
Ronald J. Korthuis, Kelly J. Peyton, Ahmad R. Shebib, Xiao-ming Liu, William Durante, Hong Wang
Publikováno v:
American journal of physiology. Heart and circulatory physiology. 300(1)
The present study determined whether AMP-activated protein kinase (AMPK) regulates heme oxygenase (HO)-1 gene expression in endothelial cells (ECs) and if HO-1 contributes to the biological actions of this kinase. Treatment of human ECs with the AMPK
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea7f71635e2fad8a2bf121aeda81c42f
https://pubmed.ncbi.nlm.nih.gov/21037234
https://pubmed.ncbi.nlm.nih.gov/21037234