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DNA-Diffusion: Leveraging Generative Models for Controlling Chromatin Accessibility and Gene Expression via Synthetic Regulatory Elements.

Autor: DaSilva LF; Department of Pathology, Harvard Medical School, Boston, MA, USA.; Molecular Pathology Unit, Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA., Senan S; Molecular Pathology Unit, Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA.; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Patel ZM; Department of Pathology, Harvard Medical School, Boston, MA, USA.; Molecular Pathology Unit, Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA.; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Janardhan Reddy A; Department of Electrical Engineering and Computer Sciences, University of California, Berkeley, CA, USA., Gabbita S; Molecular Pathology Unit, Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA.; Johns Hopkins University, Baltimore, MD, USA., Nussbaum Z; Nomic AI., Valdez Córdova CM; Johannes Kepler University, Linz, Austria., Wenteler A; Queen Mary University of London, London, UK., Weber N; TU Vienna, Austria., Tunjic TM; TU Vienna, Austria., Ahmad Khan T; Independent Researcher., Li Z; Victor Chang Cardiac Institute, Darlinghurst, New South Wales, Australia.; School of Biotechnology and Biomolecular Sciences, Faculty of Science, UNSW Sydney, Sydney, Australia., Smith C; Department of Pathology, Harvard Medical School, Boston, MA, USA.; Molecular Pathology Unit, Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA.; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Bejan M; University of Bucharest, Bucharest, Romania., Karmel Louis L; Victor Chang Cardiac Institute, Darlinghurst, New South Wales, Australia.; School of Biotechnology and Biomolecular Sciences, Faculty of Science, UNSW Sydney, Sydney, Australia., Cornejo P; Victor Chang Cardiac Institute, Darlinghurst, New South Wales, Australia.; School of Biotechnology and Biomolecular Sciences, Faculty of Science, UNSW Sydney, Sydney, Australia., Connell W; Independent Researcher., Wong ES; Victor Chang Cardiac Institute, Darlinghurst, New South Wales, Australia.; School of Biotechnology and Biomolecular Sciences, Faculty of Science, UNSW Sydney, Sydney, Australia., Meuleman W; Altius Institute for Biomedical Sciences, Seattle, WA, USA.; Paul G. Allen School of Computer Science & Engineering, University of Washington, Seattle, WA, USA., Pinello L; Department of Pathology, Harvard Medical School, Boston, MA, USA.; Molecular Pathology Unit, Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA.; Broad Institute of Harvard and MIT, Cambridge, MA, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Feb 01. Date of Electronic Publication: 2024 Feb 01.