Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Ahmad Abdelwaly"'
Autor:
Shaimaa Shouman, Nada El-Kholy, Alaa E. Hussien, Azza M. El-Derby, Shireen Magdy, Ahmed M. Abou-Shanab, Ahmed O. Elmehrath, Ahmad Abdelwaly, Mohamed Helal, Nagwa El-Badri
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-22 (2024)
Abstract T lymphocytes play a primary role in the adaptive antiviral immunity. Both lymphocytosis and lymphopenia were found to be associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). While lymphocytosis indicates an active a
Externí odkaz:
https://doaj.org/article/a749e796fe0d4547b9a77c1d9caa80c8
Autor:
Kareem A. Galal, Anna Truong, Frank Kwarcinski, Chandi de Silva, Krisha Avalani, Tammy M. Havener, Michael E. Chirgwin, Eric Merten, Han Wee Ong, Caleb Willis, Ahmad Abdelwaly, Mohamed A. Helal, Emily R. Derbyshire, Reena Zutshi, David H. Drewry
Publikováno v:
Journal of Medicinal Chemistry. 65:13172-13197
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9157dae09bb16f8beecc10edc94755ec
https://doi.org/10.1021/acs.jmedchem.2c00996
https://doi.org/10.1021/acs.jmedchem.2c00996
Autor:
Nada Elkholy, Ahmad Abdelwaly, Karim Mohamed, Emanuele Amata, Jessica Lombino, Giuseppe Cosentino, Sebastiano Intagliata, Mohamed A. Helal
Publikováno v:
Chemical Biology & Drug Design. 100:25-40
Sigma receptor is a transmembrane non-GPCR protein expressed mainly in the endoplasmic reticulum membrane associated with mitochondria. It is classified into two types: Sigma-1 (S1R) and Sigma-2 (S2R) based on their biological functions. S1R has been
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf2b53a81706e65b6f43f671f234d49c
https://doi.org/10.1111/cbdd.14047
https://doi.org/10.1111/cbdd.14047
Autor:
Kareem Galal, Anna Truong, Frank Kwarcinski, Chandi de Silva, Krisha Avalani, Tammy Havener, Michael Chirgwin, Eric Merten, Han Wee Ong, Caleb Willis, Ahmad Abdelwaly, Mohamed Helal, Emily Derbyshire, Reena Zutshi, David Drewry
The plasmodial kinases PfGSK3 and PfPK6 have been identified as essential for the asexual life stage of Plasmodium falciparum, and thus are considered viable novel drug targets to combat rising resistance to traditional antimalarial drugs. We recentl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::77a07b433f8e6d1e238e150bf4065768
https://doi.org/10.26434/chemrxiv-2022-fpv0g
https://doi.org/10.26434/chemrxiv-2022-fpv0g
Activating mutations in the EGFR kinase domain are known to be a common cause of Non-Small Cell Lung Cancer (NSCLC) and are thus targeted for treatment. First generation Tyrosine Kinase Inhibitors (TKIs) were used to treat NSCLC patients with the kno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48f3f53b39899433ef44c9a5e442ea26
Publikováno v:
Journal of Molecular Structure. 1248:131491
Phosphodiesterase-4 (PDE4) is responsible for the selective degradation of the 3ʹ-cyclic phosphate bonds of cAMP. A collection of twenty-three diverse 1,2,3,4-tertahydro-β-carboline- and indole-based analogues were synthesized and assessed for thei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e25a8661e38a7feb14ee852cdd53444d
https://doi.org/10.1016/j.molstruc.2021.131491
https://doi.org/10.1016/j.molstruc.2021.131491
Deciphering the molecular basis of the kappa opioid receptor selectivity: A Molecular Dynamics study
Autor:
Ahmad Abdelwaly, Khaled M. Darwish, Mohamed A. Helal, Amal A.M. Eissa, Amr H. Saleh, Amar G. Chittiboyina
Publikováno v:
Journal of Molecular Graphics and Modelling. 106:107940
Selective antagonists for the kappa opioid receptor (KOP) have the potential to treat opiate and alcohol addiction, as well as depression and other CNS disorders. Over the years, the development of KOP-selective antagonists yielded very few successfu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db4d50ad1e647f8c0a547582c9bff7fe
https://doi.org/10.1016/j.jmgm.2021.107940
https://doi.org/10.1016/j.jmgm.2021.107940
Publikováno v:
Medicinal Chemistry Research. 26:3173-3187
Phosphodiesterase 4 is the primary enzyme responsible for degradation of the second messenger cAMP in many of the cells releasing proinflammatory mediators. Inhibition of this enzyme could help in the management of various inflammatory conditions suc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::74edb0b9d45f5871ab5bd4ea73eef7d6
https://doi.org/10.1007/s00044-017-2011-x
https://doi.org/10.1007/s00044-017-2011-x