Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Ahmad, Wardak"'
Autor:
Ruitao Jin, Sitong He, Katrina A. Black, Oliver B. Clarke, Di Wu, Jani R. Bolla, Paul Johnson, Agalya Periasamy, Ahmad Wardak, Peter Czabotar, Peter M. Colman, Carol V. Robinson, Derek Laver, Brian J. Smith, Jacqueline M. Gulbis
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
The Kir potassium channels are known to operate and gate without a major conformational change. Here, the authors identify the permeation gate of Kir channels as a steric plug within the conduction pathway, describing how tightly associated anionic l
Externí odkaz:
https://doaj.org/article/400ab475f64247199cf3b4d67129ff32
Autor:
Emma J. Petrie, Jarrod J. Sandow, Annette V. Jacobsen, Brian J. Smith, Michael D. W. Griffin, Isabelle S. Lucet, Weiwen Dai, Samuel N. Young, Maria C. Tanzer, Ahmad Wardak, Lung-Yu Liang, Angus D. Cowan, Joanne M. Hildebrand, Wilhelmus J. A. Kersten, Guillaume Lessene, John Silke, Peter E. Czabotar, Andrew I. Webb, James M. Murphy
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
RIPK3-mediated phosphorylation of the mixed lineage kinase domain-like (MLKL) pseudokinase is thought to be the trigger for MLKL activation during necroptotic signaling. Here the authors provide evidence that the transition of human MLKL from a monom
Externí odkaz:
https://doaj.org/article/15857781bc14483aa896810340066149
Autor:
Ashish Sethi, Christopher R. Horne, Cheree Fitzgibbon, Karyn Wilde, Katherine A. Davies, Sarah E. Garnish, Annette V. Jacobsen, André L. Samson, Joanne M. Hildebrand, Ahmad Wardak, Peter E. Czabotar, Emma J. Petrie, Paul R. Gooley, James M. Murphy
Publikováno v:
Cell Death & Differentiation. 29:1804-1815
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6d11ea53912f34a2695387d2c752b028
https://doi.org/10.1038/s41418-022-00965-6
https://doi.org/10.1038/s41418-022-00965-6
Autor:
Paul Johnson, Peter M. Colman, Jani Reddy Bolla, Jacqueline M. Gulbis, Ruitao Jin, Brian J. Smith, Oliver B. Clarke, Agalya Periasamy, Di Wu, Peter E. Czabotar, Sitong He, Derek R. Laver, Ahmad Wardak, Carol V. Robinson, Katrina A. Black
Ion currents through potassium channels are gated. Constriction of the ion conduction pathway at the inner helix bundle, the textbook ‘gate’ of Kir potassium channels, has been shown to be an ineffective permeation control, creating a rift in our
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fdda3d0f0828013151fa8d078f10e0ef
https://doi.org/10.1101/2021.09.21.461288
https://doi.org/10.1101/2021.09.21.461288
Autor:
Giuseppi Infusini, Shashank Masaldan, Daisy Lio, Robert L Ninnis, Destiny Dalseno, Ahmad Wardak, Alan S Huang, Ziyan Liu, Grant Dewson, Jonathan P. Bernardini, Richard W Birkinshaw, Peter E. Czabotar, Andrew I. Webb, Jarrod J. Sandow, Iris K. L. Tan
Publikováno v:
The EMBO Journal. 40
BAK and BAX, the effectors of intrinsic apoptosis, each undergo major reconfiguration to an activated conformer that self-associates to damage mitochondria and cause cell death. However, the dynamic structural mechanisms of this reconfiguration in th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2b9bd798414b6b149b476c1026a71f59
https://doi.org/10.15252/embj.2020107237
https://doi.org/10.15252/embj.2020107237
Autor:
Jai Rautela, Peter E. Czabotar, Tobias Kratina, Christine R. Keenan, Yifan Zhan, Huon L. Wong, Nicholas D. Huntington, Manuela S Hancock, Christine A White, Emma M. Carrington, Ahmad Wardak, Vanessa L. Bryant, Wesley Wong, Rhys S. Allan, Guillaume Lessene, Yuyan Yang, Damian B D'Silva, Robyn L Schenk, Andrew M. Lew, Jacinta Hansen, Nadia Iannarella, Marco J Herold, Cynthia Louis, Robyn M. Sutherland, Ian P. Wicks, Duong Nhu
Publikováno v:
Blood Adv
Neutrophils help to clear pathogens and cellular debris, but can also cause collateral damage within inflamed tissues. Prolonged neutrophil residency within an inflammatory niche can exacerbate tissue pathology. Using both genetic and pharmacological
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebdaa032d6d3dbd2b6325707daeeec77
https://europepmc.org/articles/PMC8238482/
https://europepmc.org/articles/PMC8238482/
Autor:
Mark F. van Delft, Meng Xiao Luo, Kate McArthur, Peter E. Czabotar, Jarrod J. Sandow, Laura F. Dagley, Kym N Lowes, Jason M. Brouwer, Andrew I. Webb, Guillaume Lessene, Rachael M. Lane, Keith G. Watson, Christoph Grohmann, Ahmad Wardak, Peter M. Colman, Sabrina Bernard, Soo San Wan, Yelena Khakham, Phillip P. Sharp, Romina Lessene, Thao Nguyen, David J. Segal, David C.S. Huang, Erinna F. Lee, Lucy Li, Marlyse A. Debrincat, Grant Dewson, Chinh T. Bui, Hui San Chin, W. Douglas Fairlie, Stephane Duflocq, Benjamin T. Kile, Stephane Chappaz, Caroline Miles, Kurt Lackovic, Laure Peilleron
Publikováno v:
Nature Chemical Biology. 15:1057-1066
Activating the intrinsic apoptosis pathway with small molecules is now a clinically validated approach to cancer therapy. In contrast, blocking apoptosis to prevent the death of healthy cells in disease settings has not been achieved. Caspases have b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::21f8a84e9d19f8763b3963c4941664e3
https://doi.org/10.1038/s41589-019-0365-8
https://doi.org/10.1038/s41589-019-0365-8
Autor:
Christopher R Horne, Peter E. Czabotar, Andre L. Samson, Sarah E Garnish, James M. Murphy, Cheree Fitzgibbon, Paul R. Gooley, Ahmad Wardak, Hildebrand Jl, Annette V. Jacobsen, Wilde Kl, Emma J. Petrie, Ashish Sethi, Katherine A Davies
Necroptosis is a lytic programmed cell death pathway with origins in innate immunity that is frequently dysregulated in inflammatory diseases. The terminal effector of the pathway, MLKL, is licensed to kill following phosphorylation of its pseudokina
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a9dabeacb3fb8a41a1c7f6e66c9e0241
https://doi.org/10.1101/2021.05.03.442385
https://doi.org/10.1101/2021.05.03.442385
Autor:
Ashish, Sethi, Christopher R, Horne, Cheree, Fitzgibbon, Karyn, Wilde, Katherine A, Davies, Sarah E, Garnish, Annette V, Jacobsen, André L, Samson, Joanne M, Hildebrand, Ahmad, Wardak, Peter E, Czabotar, Emma J, Petrie, Paul R, Gooley, James M, Murphy
Publikováno v:
Cell death and differentiation. 29(9)
Necroptosis is a lytic programmed cell death pathway with origins in innate immunity that is frequently dysregulated in inflammatory diseases. The terminal effector of the pathway, MLKL, is licensed to kill following phosphorylation of its pseudokina
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0051bfe940fd210facb80b6f1db0a2b4
https://pubmed.ncbi.nlm.nih.gov/35264780
https://pubmed.ncbi.nlm.nih.gov/35264780
Autor:
Yepy H Rustam, Iris K. L. Tan, Eugene A. Kapp, Jonathan P. Bernardini, Grant Dewson, Peter M. Colman, Nicholas A. Smith, Jarrod J. Sandow, Jason M. Brouwer, M.J. Roy, Andrew I. Webb, Gavin E. Reid, Brian J. Smith, Peter E. Czabotar, Angus D. Cowan, Jacqueline M. Gulbis, James M. Murphy, Ahmad Wardak
Publikováno v:
Nature structuralmolecular biology. 27(11)
BAK and BAX are essential mediators of apoptosis that oligomerize in response to death cues, thereby causing permeabilization of the mitochondrial outer membrane. Their transition from quiescent monomers to pore-forming oligomers involves a well-char
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d09b3adc9911ffb81c34d497964c1f7
https://pubmed.ncbi.nlm.nih.gov/32929280
https://pubmed.ncbi.nlm.nih.gov/32929280