Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Ahmad, Sadruddin"'
Autor:
Simon Ng, Alexander C. Brueckner, Soheila Bahmanjah, Qiaolin Deng, Jennifer M. Johnston, Lan Ge, Ruchia Duggal, Bahanu Habulihaz, Benjamin Barlock, Sookhee Ha, Ahmad Sadruddin, Constance Yeo, Corey Strickland, Andrea Peier, Brian Henry, Edward C. Sherer, Anthony W. Partridge
Publikováno v:
Journal of Medicinal Chemistry. 65:9789-9801
STIP1 homology and U-Box containing protein 1 (STUB1) plays a key role in maintaining cell health during stress and aging. Recent evidence suggested STUB1 also helps regulate immunity with the potential of clearing malignant cells. Indeed, we and oth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82d4ec6db56ddbda74bf2aedff793236
https://doi.org/10.1021/acs.jmedchem.2c00406
https://doi.org/10.1021/acs.jmedchem.2c00406
Autor:
Kristal Kaan, Nicole Boo, Yu-Chi Angela Juang, Chandra S. Verma, Kaustav Biswas, Ruchia Duggal, Christopher J. Brown, Bhvana Bhatt, Chunhui Huang, Simon Ng, Ahmad Sadruddin, Nianyu Jason Li, Srinivasaraghavan Kannan, Shuhui Lim, Xiang Yu, Charles W. Johannes, Andrea M. Peier, Anthony W. Partridge, Erjia Wang, Lan Ge, Michael Garrigou, Pooja Gopal, Gireedhar Venkatachalam, Brian Henry, Nicolas Boyer, Khong Ming Peh, Tsz Ying Yuen, Raymond J. Gonzalez, Feifei Chen, Tomi K. Sawyer, Alexander Stoeck, Peter Orth, David P. Lane
Publikováno v:
Chemical Science
Macrocyclic peptides have the potential to address intracellular protein–protein interactions (PPIs) of high value therapeutic targets that have proven largely intractable to small molecules. Here, we report broadly applicable lessons for applying
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf11d85ecefa612930f36d6645df5d18
http://europepmc.org/articles/PMC8672774
http://europepmc.org/articles/PMC8672774
Autor:
Anthony W. Partridge, Hung Yi Kristal Kaan, Yu-Chi Juang, Ahmad Sadruddin, Shuhui Lim, Christopher J. Brown, Simon Ng, Dawn Thean, Fernando Ferrer, Charles Johannes, Tsz Ying Yuen, Srinivasaraghavan Kannan, Pietro Aronica, Yaw Sing Tan, Mohan R. Pradhan, Chandra S. Verma, Jerome Hochman, Shiying Chen, Hui Wan, Sookhee Ha, Brad Sherborne, David P. Lane, Tomi K. Sawyer
Publikováno v:
Molecules, Vol 24, Iss 12, p 2292 (2019)
Stapled α-helical peptides represent an emerging superclass of macrocyclic molecules with drug-like properties, including high-affinity target binding, protease resistance, and membrane permeability. As a model system for probing the chemical space
Externí odkaz:
https://doaj.org/article/76dd0b05d6584b64a066db0da685651e
Autor:
Charles W. Johannes, Dawn Thean, Joe R Cannon, Raymond Evers, Tanvi Desai, Hung Yi Kristal Kaan, David P. Lane, Christopher J. Brown, Ahmad Sadruddin, Anthony W. Partridge, Tsz Ying Yuen, Arun Chandramohan, Tomi K. Sawyer, Jerome Hochman, Bahanu Habulihaz
Publikováno v:
Pharmaceutical Research. 38:843-850
To develop a novel, target agnostic liposome click membrane permeability assay (LCMPA) using liposome encapsulating copper free click reagent dibenzo cyclooctyne biotin (DBCO-Biotin) to conjugate azido modified peptides that may effectively transloca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::85323783776f557af1a6d5fc227af5b3
https://doi.org/10.1007/s11095-021-03005-z
https://doi.org/10.1007/s11095-021-03005-z
Autor:
Hung Yi Kristal Kaan, Yi Han, Charles W. Johannes, Laurent Rénia, Zi Wei Chang, Brian Henry, Yaw Sing Tan, Arun Chandramohan, Yuri Frosi, Tomi K. Sawyer, Chandra S. Verma, Shiying Chen, Dawn Thean Gek Lian, Simon Ng, Tsz Ying Yuen, Jiang Shimin, Ahmad Sadruddin, Jin Huei Wong, Pietro G. A. Aronica, Christopher J. Brown, David P. Lane, Srinivasaraghavan Kannan, Prakash Arumugam, Anthony W. Partridge, Sharon Chee, Fernando J. Ferrer-Gago
Publikováno v:
Chemical Science. 11:5577-5591
Peptide-based molecules hold great potential as targeted inhibitors of intracellular protein–protein interactions (PPIs). Indeed, the vast diversity of chemical space conferred through their primary, secondary and tertiary structures allows these m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ecea1bb451ad4b3ca254360c5c786a37
https://doi.org/10.1039/c9sc06383h
https://doi.org/10.1039/c9sc06383h
Autor:
Brad Sherborne, Andrea M. Peier, Cesear Corona, Ahmad Sadruddin, David P. Lane, Fernando J. Ferrer-Gago, Kaustav Biswas, Dawn Thean, Arun Chandramohan, Tomi K. Sawyer, Christopher J. Brown, Nicolas Boyer, Lan Ge, Tsz Ying Yuen, Lin Yan, John R. Frost, Hung Yi Kristal Kaan, Scott D. Edmondson, Jeffrey D. Hermes, Anthony W. Partridge, Xue Er Lee, Ruchia Duggal, Chad Zimprich, Matthew B. Robers, Charles W. Johannes
Publikováno v:
ACS chemical biology. 16(2)
Macrocyclic peptides open new opportunities to target intracellular protein-protein interactions (PPIs) that are often considered nondruggable by traditional small molecules. However, engineering sufficient membrane permeability into these molecules
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::607ce9191a77b1a17969c8e5ffca84ec
https://pubmed.ncbi.nlm.nih.gov/33539064
https://pubmed.ncbi.nlm.nih.gov/33539064
Autor:
Tanvi J, Desai, Bahanu, Habulihaz, Joe R, Cannon, Arun, Chandramohan, Hung Yi Kristal, Kaan, Ahmad, Sadruddin, Tsz Ying, Yuen, Charles, Johannes, Dawn, Thean, Chris J, Brown, David P, Lane, Anthony W, Partridge, Raymond, Evers, Tomi K, Sawyer, Jerome, Hochman
Publikováno v:
Pharmaceutical research. 38(5)
To develop a novel, target agnostic liposome click membrane permeability assay (LCMPA) using liposome encapsulating copper free click reagent dibenzo cyclooctyne biotin (DBCO-Biotin) to conjugate azido modified peptides that may effectively transloca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a9d5959e2206b6c9ef46be0b9c76f7de
https://pubmed.ncbi.nlm.nih.gov/33821425
https://pubmed.ncbi.nlm.nih.gov/33821425
Autor:
Anthony W. Partridge, David P. Lane, Tsz Ying Yuen, Dawn Thean, Bahanu Habulihaz, Ahmad Sadruddin, Tomi K. Sawyer, Arun Chandramohan, Hung Yi Kristal Kaan, Jerome Hochman, Charles Johannes, Raymond Evers, Tanvi Desai, Christopher J. Brown, Joseph R. Cannon
Publikováno v:
Pharmaceutical Research. 38:735-736
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6d3abd67728300ac8c123e86d1152d66
https://doi.org/10.1007/s11095-021-03033-9
https://doi.org/10.1007/s11095-021-03033-9
Autor:
Charles W. Johannes, Tomi K. Sawyer, Srinivasaraghavan Kannan, Nils A. Berglund, Yu-Chi Juang, Xue’Er Cheryl Lee, Hung Yi Kristal Kaan, Chandra S. Verma, Simon Ng, Alexander Stoeck, Liew Xi, Anthony W. Partridge, Lijuan Liu, David P. Lane, Arun Chandramohan, Fernando J. Ferrer, Tsz Ying Yuen, Ahmad Sadruddin, Pietro G. A. Aronica, Christopher J. Brown
Publikováno v:
ACS Med Chem Lett
Discovery of false-positive target binding, due to assay interference or aggregation, presents a significant problem for drug discovery programs. These issues may often be unrealized and could lead researchers astray if not subject to independent ver
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a00b04284e3ebf74d3ee850f11be050
Autor:
Hui Wan, Simon Ng, Ahmad Sadruddin, Mohan R. Pradhan, Fernando J. Ferrer, David P. Lane, Yu-Chi Juang, Shuhui Lim, Dawn Thean, Tomi K. Sawyer, Chandra S. Verma, Srinivasaraghavan Kannan, Tsz Ying Yuen, Shiying Chen, Yaw Sing Tan, Brad Sherborne, Hung Yi Kristal Kaan, Jerome Hochman, Pietro G. A. Aronica, Christopher J. Brown, Anthony W. Partridge, Sookhee Ha, Charles W. Johannes
Publikováno v:
Molecules
Molecules, Vol 24, Iss 12, p 2292 (2019)
Volume 24
Issue 12
Molecules, Vol 24, Iss 12, p 2292 (2019)
Volume 24
Issue 12
Stapled &alpha
helical peptides represent an emerging superclass of macrocyclic molecules with drug-like properties, including high-affinity target binding, protease resistance, and membrane permeability. As a model system for probing the chemic
helical peptides represent an emerging superclass of macrocyclic molecules with drug-like properties, including high-affinity target binding, protease resistance, and membrane permeability. As a model system for probing the chemic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96ed2a2908a2d5f86da80ea2da3b5ad2
https://doi.org/10.3390/molecules24122292
https://doi.org/10.3390/molecules24122292