Zobrazeno 1 - 10
of 1 093
pro vyhledávání: '"Ahituv, A."'
Autor:
Florence M. Chardon, Troy A. McDiarmid, Nicholas F. Page, Riza M. Daza, Beth K. Martin, Silvia Domcke, Samuel G. Regalado, Jean-Benoît Lalanne, Diego Calderon, Xiaoyi Li, Lea M. Starita, Stephan J. Sanders, Nadav Ahituv, Jay Shendure
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract CRISPR-based gene activation (CRISPRa) is a strategy for upregulating gene expression by targeting promoters or enhancers in a tissue/cell-type specific manner. Here, we describe an experimental framework that combines highly multiplexed per
Externí odkaz:
https://doaj.org/article/9bd7fc937a4c4d249a6334bbcbf59eb9
Publikováno v:
Genome Biology, Vol 25, Iss 1, Pp 1-17 (2024)
Abstract Background Increasing evidence suggests that a substantial proportion of disease-associated mutations occur in enhancers, regions of non-coding DNA essential to gene regulation. Understanding the structures and mechanisms of the regulatory p
Externí odkaz:
https://doaj.org/article/ec34301479b54630803056cb2238b691
Autor:
Davide Capauto, Yifan Wang, Feinan Wu, Scott Norton, Jessica Mariani, Fumitaka Inoue, Gregory E. Crawford, Nadav Ahituv, Alexej Abyzov, Flora M. Vaccarino
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Regulation of gene expression through enhancers is one of the major processes shaping the structure and function of the human brain during development. High-throughput assays have predicted thousands of enhancers involved in neurodevelopment
Externí odkaz:
https://doaj.org/article/ca2e76102a6a4aa197468ba562562414
Autor:
Wei E. Gordon, Seungbyn Baek, Hai P. Nguyen, Yien-Ming Kuo, Rachael Bradley, Sarah L. Fong, Nayeon Kim, Alex Galazyuk, Insuk Lee, Melissa R. Ingala, Nancy B. Simmons, Tony Schountz, Lisa Noelle Cooper, Ilias Georgakopoulos-Soares, Martin Hemberg, Nadav Ahituv
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-23 (2024)
Abstract Frugivory evolved multiple times in mammals, including bats. However, the cellular and molecular components driving it remain largely unknown. Here, we use integrative single-cell sequencing (scRNA-seq and scATAC-seq) on insectivorous (Eptes
Externí odkaz:
https://doaj.org/article/63321723d9924faaa1c76d697644b935
Autor:
Mariam Okhovat, Jake VanCampen, Kimberly A. Nevonen, Lana Harshman, Weiyu Li, Cora E. Layman, Samantha Ward, Jarod Herrera, Jackson Wells, Rory R. Sheng, Yafei Mao, Blaise Ndjamen, Ana C. Lima, Katinka A. Vigh-Conrad, Alexandra M. Stendahl, Ran Yang, Lev Fedorov, Ian R. Matthews, Sarah A. Easow, Dylan K. Chan, Taha A. Jan, Evan E. Eichler, Sandra Rugonyi, Donald F. Conrad, Nadav Ahituv, Lucia Carbone
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract Topological associating domains (TADs) are self-interacting genomic units crucial for shaping gene regulation patterns. Despite their importance, the extent of their evolutionary conservation and its functional implications remain largely un
Externí odkaz:
https://doaj.org/article/65e9bbc94a464705ac4ea7c071b55e77
Autor:
Wang, Chenyu, Derderian, Kimberly D., Hamada, Elizabeth, Zhou, Xujia, Nelson, Andrew D., Kyoung, Henry, Ahituv, Nadav, Bouvier, Guy, Bender, Kevin J.
Publikováno v:
In Neuron 1 May 2024 112(9):1444-1455
Autor:
Aki Ushiki, Rory R. Sheng, Yichi Zhang, Jingjing Zhao, Mai Nobuhara, Elizabeth Murray, Xin Ruan, Jonathan J. Rios, Carol A. Wise, Nadav Ahituv
Publikováno v:
Cell Reports, Vol 43, Iss 3, Pp 113907- (2024)
Summary: Adolescent idiopathic scoliosis (AIS), a sideways curvature of the spine, is sexually dimorphic, with increased incidence in females. A genome-wide association study identified a female-specific AIS susceptibility locus near the PAX1 gene. H
Externí odkaz:
https://doaj.org/article/bd9e040e216d463ca06508bc1cda0996
Autor:
Hao Yu, Anas M Khanshour, Aki Ushiki, Nao Otomo, Yoshinao Koike, Elisabet Einarsdottir, Yanhui Fan, Lilian Antunes, Yared H Kidane, Reuel Cornelia, Rory R Sheng, Yichi Zhang, Jimin Pei, Nick V Grishin, Bret M Evers, Jason Pui Yin Cheung, John A Herring, Chikashi Terao, You-qiang Song, Christina A Gurnett, Paul Gerdhem, Shiro Ikegawa, Jonathan J Rios, Nadav Ahituv, Carol A Wise
Publikováno v:
eLife, Vol 12 (2024)
Adolescent idiopathic scoliosis (AIS) is a common and progressive spinal deformity in children that exhibits striking sexual dimorphism, with girls at more than fivefold greater risk of severe disease compared to boys. Despite its medical impact, the
Externí odkaz:
https://doaj.org/article/008395c97b104a1f9a8bdc58a295796f
Autor:
Ilias Georgakopoulos-Soares, Chengyu Deng, Vikram Agarwal, Candace S. Y. Chan, Jingjing Zhao, Fumitaka Inoue, Nadav Ahituv
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract The gene regulatory code and grammar remain largely unknown, precluding our ability to link phenotype to genotype in regulatory sequences. Here, using a massively parallel reporter assay (MPRA) of 209,440 sequences, we examine all possible p
Externí odkaz:
https://doaj.org/article/e639a6096e204e71ac522a5bd70fb3de
Autor:
Golan, Yarden, Ilala, Mikias, Li, Lin, Gay, Caryl, Hunagund, Soumya, Lin, Christine Y., Cassidy, Arianna G., Jigmeddagva, Unurzul, Matsui, Yusuke, Ozarslan, Nida, Asiodu, Ifeyinwa V., Ahituv, Nadav, Flaherman, Valerie J., Gaw, Stephanie L., Prahl, Mary
Publikováno v:
In iScience 20 October 2023 26(10)