Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Aharon Nachshon"'
Autor:
Roa'a H. S. Yosief, Iqbal M. Lone, Aharon Nachshon, Heinz Himmelbauer, Irit Gat‐Viks, Fuad A. Iraqi
Publikováno v:
Animal Models and Experimental Medicine, Vol 7, Iss 1, Pp 36-47 (2024)
Abstract Background Aspergillus fumigatus (Af) is one of the most ubiquitous fungi and its infection potency is suggested to be strongly controlled by the host genetic background. The aim of this study was to search for candidate genes associated wit
Externí odkaz:
https://doaj.org/article/3c0157d539514f2bb40ccca77bc89917
Autor:
Tal Fisher, Avi Gluck, Krishna Narayanan, Makoto Kuroda, Aharon Nachshon, Jason C. Hsu, Peter J. Halfmann, Yfat Yahalom-Ronen, Hadas Tamir, Yaara Finkel, Michal Schwartz, Shay Weiss, Chien-Te K. Tseng, Tomer Israely, Nir Paran, Yoshihiro Kawaoka, Shinji Makino, Noam Stern-Ginossar
Publikováno v:
Cell Reports, Vol 39, Iss 11, Pp 110954- (2022)
Summary: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) leads to shutoff of protein synthesis, and nsp1, a central shutoff factor in coronaviruses, inhibits cellular mRNA translation. However, the diverse molecular mechanisms employed b
Externí odkaz:
https://doaj.org/article/d7b13beba8354d0e9b3f2e07d1ad3167
Autor:
Bo Li, Sara M. Clohisey, Bing Shao Chia, Bo Wang, Ang Cui, Thomas Eisenhaure, Lawrence D. Schweitzer, Paul Hoover, Nicholas J. Parkinson, Aharon Nachshon, Nikki Smith, Tim Regan, David Farr, Michael U. Gutmann, Syed Irfan Bukhari, Andrew Law, Maya Sangesland, Irit Gat-Viks, Paul Digard, Shobha Vasudevan, Daniel Lingwood, David H. Dockrell, John G. Doench, J. Kenneth Baillie, Nir Hacohen
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
Here, Li et al. perform a genome-wide CRISPR screen to identify host dependency factors for influenza A virus infection and show that the host mRNA cap methyltransferase CMTR1 is important for viral cap snatching and that it affects expression of ant
Externí odkaz:
https://doaj.org/article/c1f734a4d6574c6d950eb373c2f18352
Autor:
Biana Bernshtein, Aharon Nachshon, Miri Shnayder, Lauren Stern, Selmir Avdic, Emily Blyth, David Gottlieb, Allison Abendroth, Barry Slobedman, Noam Stern-Ginossar, Michal Schwartz
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 10 (2021)
Human cytomegalovirus (HCMV) is a widespread pathogen establishing a latent infection in its host. HCMV reactivation is a major health burden in immunocompromised individuals, and is a major cause of morbidity and mortality following hematopoietic st
Externí odkaz:
https://doaj.org/article/8283ed14e8ac4952b5889e511f3871f5
Autor:
Julie Tai-Schmiedel, Sharon Karniely, Betty Lau, Adi Ezra, Erez Eliyahu, Aharon Nachshon, Karen Kerr, Nicolás Suárez, Michal Schwartz, Andrew J Davison, Noam Stern-Ginossar
Publikováno v:
PLoS Pathogens, Vol 16, Iss 4, p e1008390 (2020)
Viruses are known for their extremely compact genomes composed almost entirely of protein-coding genes. Nonetheless, four long noncoding RNAs (lncRNAs) are encoded by human cytomegalovirus (HCMV). Although these RNAs accumulate to high levels during
Externí odkaz:
https://doaj.org/article/0435113fc0764014a407f313d31e4fb6
Autor:
Vu Thuy Khanh Le-Trilling, Tanja Becker, Aharon Nachshon, Noam Stern-Ginossar, Lara Schöler, Sebastian Voigt, Hartmut Hengel, Mirko Trilling
Publikováno v:
Cell Reports, Vol 30, Iss 7, Pp 2248-2260.e5 (2020)
Summary: Human cytomegalovirus (HCMV) causes diseases in individuals with immature or compromised immunity. To evade immune control, HCMV evolved numerous antagonists targeting the interferon system at multiple levels. By comparative analysis of natu
Externí odkaz:
https://doaj.org/article/10725b32ad2b48d6accd3cd5f3a0a86b
Autor:
Miri Shnayder, Aharon Nachshon, Batsheva Rozman, Biana Bernshtein, Michael Lavi, Noam Fein, Emma Poole, Selmir Avdic, Emily Blyth, David Gottlieb, Allison Abendroth, Barry Slobedman, John Sinclair, Noam Stern-Ginossar, Michal Schwartz
Publikováno v:
eLife, Vol 9 (2020)
Human cytomegalovirus (HCMV) causes a lifelong infection through establishment of latency. Although reactivation from latency can cause life-threatening disease, our molecular understanding of HCMV latency is incomplete. Here we use single cell RNA-s
Externí odkaz:
https://doaj.org/article/72c977ce844a4995ae32d766d1ff0271
Autor:
Yaara Finkel, Dominik Schmiedel, Julie Tai-Schmiedel, Aharon Nachshon, Roni Winkler, Martina Dobesova, Michal Schwartz, Ofer Mandelboim, Noam Stern-Ginossar
Publikováno v:
eLife, Vol 9 (2020)
Human herpesvirus-6 (HHV-6) A and B are ubiquitous betaherpesviruses, infecting the majority of the human population. They encompass large genomes and our understanding of their protein coding potential is far from complete. Here, we employ ribosome-
Externí odkaz:
https://doaj.org/article/c78d0c6627de48da8bd0679726846896
Autor:
Emma Poole, Christopher J. Z. Huang, Jessica Forbester, Miri Shnayder, Aharon Nachshon, Baraa Kweider, Anna Basaj, Daniel Smith, Sarah Elizabeth Jackson, Bin Liu, Joy Shih, Fedir N. Kiskin, K. Roche, E. Murphy, Mark R. Wills, Nicholas W. Morrell, Gordon Dougan, Noam Stern-Ginossar, Amer A. Rana, John Sinclair
Publikováno v:
Frontiers in Microbiology, Vol 10 (2019)
Herpesviruses undergo life-long latent infection which can be life-threatening in the immunocompromised. Models of latency and reactivation of human cytomegalovirus (HCMV) include primary myeloid cells, cells known to be important for HCMV latent car
Externí odkaz:
https://doaj.org/article/864ac0c6b6644a0e86c75d7df117824d
Autor:
Miri Shnayder, Aharon Nachshon, Benjamin Krishna, Emma Poole, Alina Boshkov, Amit Binyamin, Itay Maza, John Sinclair, Michal Schwartz, Noam Stern-Ginossar
Publikováno v:
mBio, Vol 9, Iss 2 (2018)
ABSTRACT Primary infection with human cytomegalovirus (HCMV) results in a lifelong infection due to its ability to establish latent infection, with one characterized viral reservoir being hematopoietic cells. Although reactivation from latency causes
Externí odkaz:
https://doaj.org/article/fe4be3636745448a895fb1aea3a70ad7