Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Ahalya Balachandran"'
Autor:
Raymond W Wong, Ahalya Balachandran, Peter K Cheung, Ran Cheng, Qun Pan, Peter Stoilov, P Richard Harrigan, Benjamin J Blencowe, Donald R Branch, Alan Cochrane
Publikováno v:
PLoS Pathogens, Vol 20, Iss 4, p e1012155 (2024)
[This corrects the article DOI: 10.1371/journal.ppat.1008307.].
Externí odkaz:
https://doaj.org/article/4df4fc807faa415891ab9ebf31fee49c
Autor:
Subha Dahal, Kiera Clayton, Terek Been, Raphaële Fernet-Brochu, Alonso Villasmil Ocando, Ahalya Balachandran, Mikaël Poirier, Rebecca Kaddis Maldonado, Lulzim Shkreta, Kayluz Frias Boligan, Furkan Guvenc, Fariha Rahman, Donald Branch, Brendan Bell, Benoit Chabot, Scott D. Gray-Owen, Leslie J. Parent, Alan Cochrane
Publikováno v:
Retrovirology, Vol 19, Iss 1, Pp 1-25 (2022)
Plain Language Summary Identifying cellular factors that regulate HIV-1 RNA processing provides important insights into novel strategies to control this infection. Different members of the SR kinase family have distinct roles in regulating virus expr
Externí odkaz:
https://doaj.org/article/f6c59f5364bf49b0a2fb808840fdf7ed
Autor:
Raymond W Wong, Ahalya Balachandran, Peter K Cheung, Ran Cheng, Qun Pan, Peter Stoilov, P Richard Harrigan, Benjamin J Blencowe, Donald R Branch, Alan Cochrane
Publikováno v:
PLoS Pathogens, Vol 16, Iss 2, p e1008307 (2020)
The ability of HIV-1 to evolve resistance to combined antiretroviral therapies (cARTs) has stimulated research into alternative means of controlling this infection. We assayed >60 modulators of RNA alternative splicing (AS) to identify new inhibitors
Externí odkaz:
https://doaj.org/article/501046d94c904dac820145b551ac6fb8
Publikováno v:
PLoS Pathogens, Vol 9, Iss 3, p e1003241 (2013)
To develop new approaches to control HIV-1 replication, we examined the capacity of recently described small molecular modulators of RNA splicing for their effects on viral RNA metabolism. Of the drugs tested, digoxin was found to induce a dramatic i
Externí odkaz:
https://doaj.org/article/95a9ba8c7b84431d9b7b397a830a71d8
Autor:
Brendan Bell, P. Richard Harrigan, Johanne Toutant, Marco Blanchette, David S. Grierson, Ahalya Balachandran, Benjamin A. Story, Lulzim Shkreta, Peter K. Cheung, Alan Cochrane, Emmanuelle Wilhelm, Benoit Chabot
Publikováno v:
Nucleic Acids Research
We recently identified the 4-pyridinone-benzisothiazole carboxamide compound 1C8 as displaying strong anti-HIV-1 potency against a variety of clinical strains in vitro. Here we show that 1C8 decreases the expression of HIV-1 and alters splicing event
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bad1baac199e7ec18a70ad365c8bac8
https://doi.org/10.1093/nar/gkw1223
https://doi.org/10.1093/nar/gkw1223
Autor:
P. Richard Harrigan, Peter K. Cheung, Donald R. Branch, Ran Cheng, Alan Cochrane, Ahalya Balachandran, Benjamin J. Blencowe, Peter Stoilov, Qun Pan, Raymond Wong
Publikováno v:
PLoS Pathogens, Vol 16, Iss 2, p e1008307 (2020)
PLoS Pathogens
PLoS Pathogens
The ability of HIV-1 to evolve resistance to combined antiretroviral therapies (cARTs) has stimulated research into alternative means of controlling this infection. We assayed >60 modulators of RNA alternative splicing (AS) to identify new inhibitors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c00b3bf97a18f7546f7583e29b73f2a8
https://doi.org/10.1371/journal.ppat.1008307
https://doi.org/10.1371/journal.ppat.1008307
Autor:
Ahalya Balachandran, Alan Cochrane
Publikováno v:
Methods (San Diego, Calif.). 126
The control of RNA processing plays an important role in the nature and quantity of protein generated from mammalian genes. Consequently, efforts to manipulate RNA processing have the capacity to significantly impact gene function. Although multiple
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57b542ca746a00cc37c17ed78cd12e40
https://pubmed.ncbi.nlm.nih.gov/28600226
https://pubmed.ncbi.nlm.nih.gov/28600226
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 9, Iss 3, p e1003241 (2013)
PLoS Pathogens, Vol 9, Iss 3, p e1003241 (2013)
To develop new approaches to control HIV-1 replication, we examined the capacity of recently described small molecular modulators of RNA splicing for their effects on viral RNA metabolism. Of the drugs tested, digoxin was found to induce a dramatic i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09e1752cd526f6a05cf4dd63ad16182f
https://pubmed.ncbi.nlm.nih.gov/23555254
https://pubmed.ncbi.nlm.nih.gov/23555254
Publikováno v:
Retrovirology
Background Control of RNA processing plays a central role in the expression of the HIV-1 genome. From a single 9kb transcript, more than 40 mRNAs are generated through suboptimal splicing, a subset of which are dependent upon the HIV-1 factor Rev for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcd59694d20ece4eb13744aa17d57680
http://europepmc.org/articles/PMC3848095
http://europepmc.org/articles/PMC3848095
Autor:
Sandy Pan, Raymond Wong, P. Richard Harrigan, Ahalya Balachandran, Peter Stoilov, Benjamin J. Blencowe, Peter K. Cheung, Alan Cochrane
Publikováno v:
Retrovirology
Background HIV-1 replication is critically dependent upon controlled processing of its RNA and the activities provided by its encoded regulatory factors Tat and Rev. A screen of small molecule modulators of RNA processing identified several which inh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ca4d7177649680b9dfbdcf48e195d98