Zobrazeno 1 - 10
of 6 941
pro vyhledávání: '"AhR"'
Autor:
Takeshi Yasuda, Tomohisa Takagi, Kohei Asaeda, Hikaru Hashimoto, Mariko Kajiwara, Yuka Azuma, Hiroaki Kitae, Yasuko Hirai, Katsura Mizushima, Toshifumi Doi, Ken Inoue, Osamu Dohi, Naohisa Yoshida, Kazuhiko Uchiyama, Takeshi Ishikawa, Hideyuki Konishi, Yuichi Ukawa, Akiko Kohara, Masatake Kudoh, Ryo Inoue, Yuji Naito, Yoshito Itoh
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Maintaining the mucus layer is crucial for the innate immune system. Urolithin A (Uro A) is a gut microbiota-derived metabolite; however, its effect on mucin production as a physical barrier remains unclear. This study aimed to elucidate the
Externí odkaz:
https://doaj.org/article/52427b2d7a264fa0b2fe3c9fb621bc4e
Autor:
Arnaud Jacquerie, Ann Hoeben, Daniëlle B. P. Eekers, Alida A. Postma, Maxime Vanmechelen, Frederik de Smet, Linda Ackermans, Monique Anten, Kim Severens, Axel zur Hausen, Martinus P. G. Broen, Jan Beckervordersandforth
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-8 (2024)
Abstract Glioblastoma (GBM) continues to exhibit a discouraging survival rate despite extensive research into new treatments. One factor contributing to its poor prognosis is the tumor's immunosuppressive microenvironment, in which the kynurenine pat
Externí odkaz:
https://doaj.org/article/0c333146661840be874a5e7bc5fc17a2
Autor:
Mina Rahmati, Mojtaba Zare Ebrahimabad, Alale Langari, Ali Najafi, Shohreh Taziki, Alireza Norouzi, Mehrdad Teimoorian, Milad Khorasani, Saeed Mohammadi
Publikováno v:
Immuno, Vol 4, Iss 2, Pp 159-171 (2024)
Chronic hepatitis B (CHB) poses treatment challenges, with treatment response and disease outcome often determined by the immune response, particularly mononuclear phagocytes. Monocytes can differentiate into various subpopulations influenced by AHR.
Externí odkaz:
https://doaj.org/article/9347c79f21a94382972da35e101d24cd
Autor:
Manxiu Huai, Yingjie Wang, Junhao Li, Jiaxing Pan, Fang Sun, Feiyu Zhang, Yi Zhang, Leiming Xu
Publikováno v:
Journal of Nanobiotechnology, Vol 22, Iss 1, Pp 1-17 (2024)
Abstract Imperceptible examination and unideal treatment effect are still intractable difficulties for the clinical treatment of pancreatic ductal adenocarcinoma (PDAC). At present, despite 5-fluorouracil (5-FU), as a clinical first-line FOLFIRINOX c
Externí odkaz:
https://doaj.org/article/4cfd0131ed7f45a695d4fe096f464496
Autor:
Hang Yu, Jingmin Fan, Rui Xue, Jiawei Guan, Fangyuan Tian, Yu Xu, Linyun He, Ji Liu, Zhenzhu Du, Daqun Chen, Wei Yu, Wen Chen, Bo Han
Publikováno v:
Food Frontiers, Vol 5, Iss 3, Pp 1320-1337 (2024)
Abstract Alhagi honey (AH) is produced in arid and hot areas of Central Asia, and its polysaccharides (AP) are widely known for their activity in the treatment of intestinal diseases such as diarrhea. However, the therapeutic potential and mechanism
Externí odkaz:
https://doaj.org/article/c30d72b6be3348bca67e94703d073bb4
Autor:
Fatemah Bahman, Khubaib Choudhry, Fatema Al-Rashed, Fahd Al-Mulla, Sardar Sindhu, Rasheed Ahmad
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
The aryl hydrocarbon receptor (AhR) is a versatile environmental sensor and transcription factor found throughout the body, responding to a wide range of small molecules originating from the environment, our diets, host microbiomes, and internal meta
Externí odkaz:
https://doaj.org/article/4e0144c1dbbb494c8b09a0a96856fe6e
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 18 (2024)
The Aryl hydrocarbon receptor (AHR) is a cytosolic receptor and ligand-activated transcription factor widely expressed across various cell types in the body. Its signaling is vital for host responses at barrier sites, regulating epithelial renewal, b
Externí odkaz:
https://doaj.org/article/917ab610c8ec4b3b8bb47b6ba1cfa34d
Publikováno v:
Journal of Cutaneous Immunology and Allergy, Vol 7 (2024)
Background: Tapinarof is a nonsteroidal, topical, aryl hydrocarbon receptor agonist. Tapinarof has been shown to be efficacious and have acceptable safety profile in the treatment of atopic dermatitis (AD).Objective: We sought to evaluate the improve
Externí odkaz:
https://doaj.org/article/ca3f5f18158f423495f802d4db1d2eb1
Autor:
Yufei Liu, Shusen Fang, Tianshu Lin, Wei Chen, Yushan Chen, Ye Wang, Xietian Xiao, Hengfa Zheng, Lulu Liu, Jiayu Zhou, Yan Jiang, Qiuhan Hua, Yiguo Jiang
Publikováno v:
Environment International, Vol 190, Iss , Pp 108829- (2024)
Exposure to environmental carcinogens is a significant contributor to cancer development, with genetic and epigenetic alterations playing pivotal roles in the carcinogenic process. However, the interplay between epigenetic regulation and genetic chan
Externí odkaz:
https://doaj.org/article/1138450291cd44e6aeba8ae9a81b1e60
Autor:
Meiqing Li, Qiaohua Yan, Changquan Chen, Tingting Hu, Hongmei Yin, Ling Zhao, Fei Shi, Gang Ye, Lizi Yin, Xiaoxia Liang, Yinglun Li, Huaqiao Tang
Publikováno v:
Ecotoxicology and Environmental Safety, Vol 280, Iss , Pp 116520- (2024)
Early studies have shown that the gut microbiota is a critical target during cadmium exposure. The prebiotic activity of epigallocatechin-3-gallate (EGCG) plays an essential role in treating intestinal inflammation and damage. However, the exact inte
Externí odkaz:
https://doaj.org/article/a275c163daeb4a65a6132bd6c07024cc