Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Ah-Rum Baek"'
Autor:
Md. Kamrul Islam, Ah-Rum Baek, Byeong-Woo Yang, Soyeon Kim, Dong Wook Hwang, Sung-Wook Nam, Gang-Ho Lee, Yongmin Chang
Publikováno v:
Pharmaceuticals, Vol 16, Iss 4, p 602 (2023)
Magnetic resonance imaging (MRI) is increasingly used to diagnose focal and diffuse liver disorders. Despite their enhanced efficacy, liver-targeted gadolinium-based contrast agents (GBCAs) raise safety concerns owing to the release of toxic Gd3+ ion
Externí odkaz:
https://doaj.org/article/9a724ad4a3ee467992f1d23645fc3eec
Autor:
Bokyung Sung, Hee-Kyung Kim, Ah-Rum Baek, Byeong-Woo Yang, Yeoun-Hee Kim, Garam Choi, Hyun-Jin Park, Minsup Kim, Jongmin Lee, Yongmin Chang
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 7, p 6870 (2023)
Studies have been actively conducted to ensure that gadolinium-based contrast agents for magnetic resonance imaging (MRI) are accompanied by various biological functions. A new example is the anti-inflammatory theragnostic MRI agent to target inflamm
Externí odkaz:
https://doaj.org/article/46156ea9fba740a2a6004da53f18acb9
Autor:
Md. Kamrul Islam, Seongmin Ha, Ah-Rum Baek, Byeong-Woo Yang, Yeoun-Hee Kim, Hyun-Jin Park, Minsup Kim, Sung-Wook Nam, Gang-Ho Lee, Yongmin Chang
Publikováno v:
Pharmaceuticals, Vol 15, Iss 6, p 751 (2022)
Here, we describe the synthesis, characterization, and in vitro biological evaluation of a series of transition metal complexes containing benzothiazole aniline (BTA). We employed BTA, which is known for its selective anticancer activity, and a salen
Externí odkaz:
https://doaj.org/article/709a1ff05e074f97895f16748f01f01a
Autor:
Hyeji Lee, Kanghye Bae, Ah-Rum Baek, Eun-Bin Kwon, Yeoun-Hee Kim, Sung-Wook Nam, Gang Ho Lee, Yongmin Chang
Publikováno v:
Pharmaceutics, Vol 14, Iss 5, p 1002 (2022)
The use of cancer-derived exosomes has been studied in several cancer types, but the cancer-targeting efficacy of glioma-derived exosomes has not been investigated in depth for malignant glioblastoma (GBM) cells. In this study, exosomes were derived
Externí odkaz:
https://doaj.org/article/6a6e4f8f1e614244a87cf422f80fd3d7
Autor:
Md. Kamrul Islam, Ah-Rum Baek, Bokyung Sung, Byeong-Woo Yang, Garam Choi, Hyun-Jin Park, Yeoun-Hee Kim, Minsup Kim, Seongmin Ha, Gang-Ho Lee, Hee-Kyung Kim, Yongmin Chang
Publikováno v:
Pharmaceuticals, Vol 14, Iss 8, p 832 (2021)
We describe the synthesis, characterization, molecular modeling, and in vitro anticancer activity of three benzothiazole aniline (BTA) ligands and their corresponding platinum (II) complexes. We designed the compounds based on the selective antitumor
Externí odkaz:
https://doaj.org/article/f95c16d26e8440da93338c2459fa054d
Autor:
Byeong Woo Yang, Sohyeon Yang, Soyeon Kim, Ah Rum Baek, Bokyung Sung, Yeoun-Hee Kim, Jung Tae Lee, Sang Yun Lee, Hee-Kyung Kim, Garam Choi, Ji-Ae Park, Sung-Wook Nam, Gang-Ho Lee, Yongmin Chang
Publikováno v:
Antioxidants; Volume 11; Issue 12; Pages: 2470
In this study, we designed, synthesized, and evaluated gadolinium compounds conjugated with flavonoids as potential theranostic agents for the treatment of inflammation. These novel theranostic agents combine a molecular imaging agent and one of thre
Autor:
Ji-ung Yang, Soyeon Kim, Art E. Cho, Byeong Woo Yang, Bokyung Sung, Yeoun-Hee Kim, Yongmin Chang, Chang-Hoon Shin, Ah Rum Baek, Minsup Kim, Hee-Kyung Kim, Hoesu Jung, Taekwan Lee, Jung-jin Lee
Publikováno v:
Journal of Industrial and Engineering Chemistry. 95:83-91
Glutamate is an important excitatory neurotransmitter, and vesicular glutamate transporters (VGLUTs) are critical in regulating the extent of glutamate release. Because initial increase and late stage decrease in VGLUT expression were implicated in p
Autor:
Ah Rum Baek, Hee-Kyung Kim, Soyeon Kim, Ji-ung Yang, Min-Kyoung Kang, Jae Jun Lee, Bokyung Sung, Hyeji Lee, Minsup Kim, Art E. Cho, Ji-Ae Park, Yongmin Chang
Publikováno v:
Journal of medicinal chemistry. 65(8)
The purpose of this study is to assess the physicochemical properties and MRI diagnostic efficacy of two newly synthesized 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA)-type Gd chelates, Gd-SucL and Gd-GluL, with an asymmetric α-su
Autor:
Art E. Cho, Ah Rum Baek, Ji-ung Yang, Soyeon Kim, Garam Choi, Minsup Kim, Min Jung Kim, Gang Ho Lee, Taekwan Lee, Yongmin Chang, Hoesu Jung, Hee-Kyung Kim
Publikováno v:
Journal of Industrial and Engineering Chemistry. 83:214-223
Multifunctional imaging of the deposition of amyloid-beta (Aβ) aggregates in the brain is of great importance in diagnosing Alzheimer’s disease. Herein, we report a multifunctional Aβ-targeting small-molecular-weight gadolinium (Gd)-based contras
Autor:
Minsup Kim, Art E. Cho, Hyojeung Kang, Seon Hee Choi, Md. Kamrul Islam, Ji-Ae Park, Ah Rum Baek, Yongmin Chang, Hee-Kyung Kim, Garam Choi, Bo Kyung Sung, Gang Ho Lee, Soyeon Kim, Taekwan Lee, Young-Mi Lee, Yeoun-Hee Kim
Publikováno v:
Bioconjugate Chemistry. 29:3614-3625
In this study, we designed and synthesized a highly stable manganese (Mn2+)-based hepatobiliary complex by tethering an ethoxybenzyl (EOB) moiety with an ethylenediaminetetraacetic acid (EDTA) coordination cage as an alternative to the well-establish