Zobrazeno 1 - 10
of 193
pro vyhledávání: '"Ah Calvert"'
Autor:
JM Walling, AH Calvert
Publikováno v:
British Journal of Cancer
MTA (LY231514), a multi-targeted antifolate, is a classical antifolate undergoing intracellular polyglutamation. Polyglutamated MTA is a potent thymidylate synthase (TS) inhibitor and inhibits other folate-dependent enzymes, including dihydrofolate r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90af06cc999e7f7322d137d1fff0960e
http://europepmc.org/articles/PMC2062802
http://europepmc.org/articles/PMC2062802
Publikováno v:
Advances in Enzyme Regulation. 31:13-27
Heterocyclic para-aminobenzoate modifications of 2-desamino-2-methyl-5,8-dideazafolic acid and a series of its N10-substituted analogs have produced a number of interesting compounds that have enabled a deeper understanding of the biochemical events
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c6c67404ca23a96fab07a73ba123b3a
https://doi.org/10.1016/0065-2571(91)90006-8
https://doi.org/10.1016/0065-2571(91)90006-8
Publikováno v:
Europe PubMed Central
(6R)-5,10-Dideaza-5,6,7,8-tetrahydrofolic acid (lometrexol) is an antipurine antifolate which selectively inhibits glycinamide ribonucleotide formyltransferase. Lometrexol pharmacokinetics were evaluated in 17 patients (32 courses) as part of a Phase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::a9936baa9c50ba34b106ef1d719ae244
https://pubmed.ncbi.nlm.nih.gov/9815947
https://pubmed.ncbi.nlm.nih.gov/9815947
Autor:
Vassilios Bavetsias, D. I. Jodrell, Ah Calvert, Kenneth R. Harrap, M N Smith, F. T. Boyle, R. Kimbell, T. C. Stephens, Ann L. Jackman, G. M. F. Bisset, W. Gibson
Publikováno v:
Advances in Experimental Medicine and Biology ISBN: 9781461362876
Quinazoline analogues of folic acid have been developed successfully as thymidylate synthase (TS) inhibitors which possess clinical activity. CB3717 (N10-propargyl-5,8-dideazafolic acid), the first of these agents to receive clinical study, was withd
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::771312703dc602ef2d2cac9836331d25
https://doi.org/10.1007/978-1-4615-2960-6_118
https://doi.org/10.1007/978-1-4615-2960-6_118
Publikováno v:
Biochemical Pharmacology. 35:3871-3877
Dipyridamole is a non-specific inhibitor of nucleoside transport into mammalian cells. It is currently undergoing clinical evaluation in combination with various antimetabolites in an attempt to enhance the activity of these anticancer drugs by block
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d234e8489b1a0aee82b1e2bc33c868a4
https://doi.org/10.1016/0006-2952(86)90678-7
https://doi.org/10.1016/0006-2952(86)90678-7
Autor:
J. Humphreys, Peter Selby, C. Viner, Ah Calvert, S. Hobbs, A. L. Jones, David R. Newell, E. Jackson, T. J. McElwain, K. Fearon
Publikováno v:
British Journal of Cancer
Eighteen patients with advanced cancer have been treated intravenously with human recombinant tumour necrosis factor (rhTNF). The drug produced febrile reactions at all doses although these were preventable by steroids and indomethacin. Doses at or a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87ffc703b63ff3625e9d43dc93213f99
https://doi.org/10.1038/bjc.1987.294
https://doi.org/10.1038/bjc.1987.294
Autor:
Ah Calvert, L.R. Hughes, Kenneth R. Harrap, David Richard Newell, G.A. Taylor, Ann L. Jackman
Publikováno v:
Advances in Enzyme Regulation. 29:161-179
N10-Propargyl-5,8-dideazafolic acid (CB3717) has proved to be an interesting recent addition to the spectrum of antifolate drugs. Its sole biochemical locus of action appears to be thymidylate synthase, an inhibitory effect which is potentiated by in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e44fd540127edba95a78f19f2c19f6c2
https://doi.org/10.1016/0065-2571(89)90099-x
https://doi.org/10.1016/0065-2571(89)90099-x
Publikováno v:
Biochemical Pharmacology. 33:3269-3275
CB3717 (N-(4-(N-((2-amino-4-hydroxy-6-quinazolinyl)methyl)prop-2-ynylamino)benzoyl)-l-glutamic acid) is an antitumour agent that inhibits thymidylate synthetase (TS). A dose-dependent fall in plasma thymidine (dThd) (1.43 μM to 0.47 μM) occurred in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::411809b8cada13e9d1edebaef879b6f9
https://doi.org/10.1016/0006-2952(84)90089-3
https://doi.org/10.1016/0006-2952(84)90089-3
Autor:
L A Gumbrell, E Wiltshaw, Ian Judson, M Burnell, F. E. Boxall, David Richard Newell, Martin Gore, S O'Reilly, Zahid H Siddik, Ah Calvert
Publikováno v:
Journal of Clinical Oncology. 7:1748-1756
A dosage formula has been derived from a retrospective analysis of carboplatin pharmacokinetics in 18 patients with pretreatment glomerular filtration rates (GFR) in the range of 33 to 136 mL/min. Carboplatin plasma clearance was linearly related to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0847945d4a29758b1851b734db25730f
https://doi.org/10.1200/jco.1989.7.11.1748
https://doi.org/10.1200/jco.1989.7.11.1748
Publikováno v:
British Journal of Cancer
Forty-six patients who were treated with cisplatin or carboplatin for ovarian cancer developed resistant disease (no change in measurable disease or progressive disease) and 'crossed over' to the other platinum compound. Three patients (6.5%) respond
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75bbf846384348d1c80fa1c0c03483bd
http://europepmc.org/articles/PMC2247292
http://europepmc.org/articles/PMC2247292