Zobrazeno 1 - 10
of 1 687
pro vyhledávání: '"Aguzzi P"'
In recent advancements in machine learning, federated learning allows a network of distributed clients to collaboratively develop a global model without needing to share their local data. This technique aims to safeguard privacy, countering the vulne
Externí odkaz:
http://arxiv.org/abs/2407.12410
Autor:
Casadei, Roberto, Aguzzi, Gianluca, Audrito, Giorgio, Damiani, Ferruccio, Pianini, Danilo, Scarso, Giordano, Torta, Gianluca, Viroli, Mirko
Today's distributed and pervasive computing addresses large-scale cyber-physical ecosystems, characterised by dense and large networks of devices capable of computation, communication and interaction with the environment and people. While most resear
Externí odkaz:
http://arxiv.org/abs/2406.04780
Swarm behaviour engineering is an area of research that seeks to investigate methods and techniques for coordinating computation and action within groups of simple agents to achieve complex global goals like pattern formation, collective movement, cl
Externí odkaz:
http://arxiv.org/abs/2401.10969
Direct and indirect regulation of β-glucocerebrosidase by the transcription factors USF2 and ONECUT2
Autor:
Kathi Ging, Lukas Frick, Johannes Schlachetzki, Andrea Armani, Yanping Zhu, Pierre-André Gilormini, Ashutosh Dhingra, Desirée Böck, Ana Marques, Matthew Deen, Xi Chen, Tetiana Serdiuk, Chiara Trevisan, Stefano Sellitto, Claudio Pisano, Christopher K. Glass, Peter Heutink, Jiang-An Yin, David J. Vocadlo, Adriano Aguzzi
Publikováno v:
npj Parkinson's Disease, Vol 10, Iss 1, Pp 1-18 (2024)
Abstract Mutations in GBA1 encoding the lysosomal enzyme β-glucocerebrosidase (GCase) are among the most prevalent genetic susceptibility factors for Parkinson’s disease (PD), with 10–30% of carriers developing the disease. To identify genetic m
Externí odkaz:
https://doaj.org/article/4c0ae1d7d594437b8f6bf9199fd5b7f6
Autor:
Julia Sala-Jarque, Vanessa Gil, Pol Andrés-Benito, Inés Martínez-Soria, Pol Picón-Pagès, Félix Hernández, Jesús Ávila, José Luis Lanciego, Mario Nuvolone, Adriano Aguzzi, Rosalina Gavín, Isidro Ferrer, José Antonio del Río
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract The cellular prion protein (PrPC) plays many roles in the developing and adult brain. In addition, PrPC binds to several amyloids in oligomeric and prefibrillar forms and may act as a putative receptor of abnormal misfolded protein species.
Externí odkaz:
https://doaj.org/article/2f78e00735454e27858d150cc64c59b9
Autor:
Marco Losa, Marc Emmenegger, Pierre De Rossi, Patrick M Schürch, Tetiana Serdiuk, Niccolò Pengo, Danaëlle Capron, Dimitri Bieli, Niklas Bargenda, Niels J Rupp, Manfredi C Carta, Karl J Frontzek, Veronika Lysenko, Regina R Reimann, Petra Schwarz, Mario Nuvolone, Gunilla T Westermark, K Peter R Nilsson, Magdalini Polymenidou, Alexandre PA Theocharides, Simone Hornemann, Paola Picotti, Adriano Aguzzi
Publikováno v:
EMBO Molecular Medicine, Vol 16, Iss 9, Pp 2024-2042 (2024)
Abstract Extracellularly released molecular inflammasome assemblies -ASC specks- cross-seed Aβ amyloid in Alzheimer’s disease. Here we show that ASC governs the extent of inflammation-induced amyloid A (AA) amyloidosis, a systemic disease caused b
Externí odkaz:
https://doaj.org/article/361701b3ccf5457e8ccf997a37e06f01
Publikováno v:
Dialogues in Health, Vol 5, Iss , Pp 100185- (2024)
Background: Traditional healing practices are prevalent in rural and mountainous areas of India where Western medicine is not accessible. WHO guidelines recommend integration of traditional and Western medicine to meet rural primary care needs. We ex
Externí odkaz:
https://doaj.org/article/adc0c8b2dd864f24a875602d7a9a64a3
Autor:
Alexis Villalobos Monge, Mario Villatoro-Sánchez, Gustavo Quesada Roldán, Melissa Aguzzi Fallas, Carlos Loría Quirós
Publikováno v:
Actualidades Investigativas en Educación, Vol 25, Iss 1 (2024)
La pandemia de COVID-19 ha transformado profundamente las estrategias educativas empleadas en diversos cursos universitarios. En particular, los cursos de Agronegocios no han sido ajenos a estos cambios. El objetivo del estudio fue explorar la percep
Externí odkaz:
https://doaj.org/article/b3dfb1acb6664c8285313869b5d8b018
Autor:
PLOS Pathogens Editors, Johannes Haybaeck, Mathias Heikenwalder, Britta Klevenz, Petra Schwarz, Ilan Margalith, Claire Bridel, Kirsten Mertz, Elizabeta Zirdum, Benjamin Petsch, Thomas J Fuchs, Lothar Stitz, Adriano Aguzzi
Publikováno v:
PLoS Pathogens, Vol 20, Iss 7, p e1012396 (2024)
Externí odkaz:
https://doaj.org/article/dca854d308c848918555e1b6afe268ac
Autor:
Jacopo Aguzzi, Laurenz Thomsen, Sascha Flögel, Nathan J. Robinson, Giacomo Picardi, Damianos Chatzievangelou, Nixon Bahamon, Sergio Stefanni, Jordi Grinyó, Emanuela Fanelli, Cinzia Corinaldesi, Joaquin Del Rio Fernandez, Marcello Calisti, Furu Mienis, Elias Chatzidouros, Corrado Costa, Simona Violino, Michael Tangherlini, Roberto Danovaro
Publikováno v:
Engineering, Vol 34, Iss , Pp 195-211 (2024)
The United Nations (UN)’s call for a decade of “ecosystem restoration” was prompted by the need to address the extensive impact of anthropogenic activities on natural ecosystems. Marine ecosystem restoration is increasingly necessary due to inc
Externí odkaz:
https://doaj.org/article/c24b4b44dff842a194ea87c9a7afa78c