Cyclin Kinase-independent role of p21CDKN1A in the promotion of nascent DNA elongation in unstressed cells

Autor: Sabrina F Mansilla, Agustina P Bertolin, Valérie Bergoglio, Marie-Jeanne Pillaire, Marina A González Besteiro, Carlos Luzzani, Santiago G Miriuka, Christophe Cazaux, Jean-Sébastien Hoffmann, Vanesa Gottifredi

Publikováno v: eLife, Vol 5 (2016)

The levels of the cyclin-dependent kinase (CDK) inhibitor p21 are low in S phase and insufficient to inhibit CDKs. We show here that endogenous p21, instead of being residual, it is functional and necessary to preserve the genomic stability of unstre

Externí odkaz: https://doaj.org/article/fdcca759a1ca4184b1a2a106e5a298e3

Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp14/nsp10 exoribonuclease

Autor: Berta Canal, Allison W. McClure, Joseph F. Curran, Mary Wu, Rachel Ulferts, Florian Weissmann, Jingkun Zeng, Agustina P. Bertolin, Jennifer C. Milligan, Souradeep Basu, Lucy S. Drury, Tom Deegan, Ryo Fujisawa, Emma L. Roberts, Clovis Basier, Karim Labib, Rupert Beale, Michael Howell, John F.X Diffley

Publikováno v: Biochemical Journal

SummarySARS-CoV-2 is a coronavirus that emerged in 2019 and rapidly spread across the world causing a deadly pandemic with tremendous social and economic costs. Healthcare systems worldwide are under great pressure, and there is urgent need for effec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fecacd84c888a43831e441cefbc679e
http://europepmc.org/articles/PMC8286829

Identifying SARS-CoV-2 Antiviral Compounds by Screening for Small Molecule Inhibitors of Nsp13 Helicase

Autor: John W. McCauley, Ruth Harvey, Mary Wu, Laura E. McCoy, Agustina P Bertolin, Viktor Posse, Rupert Beale, Lucy S. Drury, John F.X. Diffley, Svend Kjaer, Saira Hussain, Berta Canal, Annabel Borg, Florian Weissmann, Jingkun Zeng, Jennifer C. Milligan, Rachel Ulferts, Michael Howell, Chloe Roustan

Publikováno v: Biochemical Journal

SummaryThe coronavirus disease 2019 (COVID-19) pandemic, which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a global public health challenge. While the efficacy of vaccines against emerging and future virus variants re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2be294aa30a2fa0bdf7de7e17f9f7f6
https://doi.org/10.1101/2021.04.07.438808

Rhythmic behavior is controlled by the SRm160 splicing factor in Drosophila melanogaster

Autor: Sofía Polcowñuk, Esteban J. Beckwith, M. Fernanda Ceriani, Carlos Esteban Hernando, Estefania Mancini, Marcelo J. Yanovsky, Agustina P Bertolin

Circadian clocks organize the metabolism, physiology, and behavior of organisms throughout the day–night cycle by controlling daily rhythms in gene expression at the transcriptional and post-transcriptional levels. While many transcription factors

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5ffe0a3127b324d502461886647276d
http://www.genetics.org/content/207/2/593

Cyclin Kinase-independent role of p21CDKN1A in the promotion of nascent DNA elongation in unstressed cells

Autor: Carlos Luzzani, Valérie Bergoglio, Santiago Gabriel Miriuka, Marina A González Besteiro, Jean-Sébastien Hoffmann, Marie-Jeanne Pillaire, Agustina P Bertolin, Christophe Cazaux, Sabrina F. Mansilla, Vanesa Gottifredi

Publikováno v: eLife
eLife, eLife Sciences Publication, 2016, 5, ⟨10.7554/eLife.18020⟩
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
eLife, Vol 5 (2016)

The levels of the cyclin-dependent kinase (CDK) inhibitor p21 are low in S phase and insufficient to inhibit CDKs. We show here that endogenous p21, instead of being residual, it is functional and necessary to preserve the genomic stability of unstre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b8d24179f21de02bc56652cbb550b57
https://hal.archives-ouvertes.fr/hal-02325733