Zobrazeno 1 - 10 of 32 pro vyhledávání: '"Agustina Chidichimo"'
1
The protein family TcTASV-C is a novel Trypanosoma cruzi virulence factor secreted in extracellular vesicles by trypomastigotes and highly expressed in bloodstream forms
Autor: Lucas D. Caeiro, Mariana Rizzi, Matias Exequiel Rodriguez, María Elisa Solana, Agustina Chidichimo, Valeria Tekiel, Daniel O. Sánchez, Giselle Rodriguez, Gabriela V. Levy, Catalina D. Alba-Soto
Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, Vol 12, Iss 5, p e0006475 (2018)
TcTASV-C is a protein family of about 15 members that is expressed only in the trypomastigote stage of Trypanosoma cruzi. We have previously shown that TcTASV-C is located at the parasite surface and secreted to the medium. Here we report that the ex
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0234cddd0b4f782c04fdd904202c0671
https://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0006475
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2
Synthesis of 2-Hydrazolyl-4-Thiazolidinones Based on Multicomponent Reactions and Biological Evaluation Against Trypanosoma Cruzi
Autor: Cecilia Saiz, Graciela Mahler, Agustina Chidichimo, Luis Enrique Bruno Blanch, Alan Talevi, Diego Benítez, Peter Wipf, Pablo Hernán Palestro, Carolina Leticia Bellera, Luciana Gavernet, Chiara Pizzo, Juan José Cazzulo
Publikováno v: Chemical Biology & Drug Design. 77:166-172
A series of 18 novel 2-hydrazolyl-4-thiazolidinones-5-carboxylic acids, amides and 5,6-α,β-unsaturated esters were synthesized, and their in vitro activity on cruzipain and T. cruzi epimastigotes was determined. Some agents show activity at 37 μm
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a745321303bf27d35d13e7e4a386b3fa
https://doi.org/10.1111/j.1747-0285.2010.01071.x
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3
Second generation of 2H-benzimidazole 1,3-dioxide derivatives as anti-trypanosomatid agents: Synthesis, biological evaluation, and mode of action studies
Autor: Mercedes González, Agustina Chidichimo, Alicia Merlino, Paola Hernández, Mariana Boiani, Juan José Cazzulo, Lucía Boiani, Hugo Cerecetto
Publikováno v: European Journal of Medicinal Chemistry. 44:4426-4433
Exploring the influence of different substitution patterns of 2H-benzimidazole 1,3-dioxide derivatives (BzNO) we prepared fifteen new derivatives. Initially the BzNO were tested against Trypanosoma cruzi Tulahuen 2 strain epimastigote form rendering
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::250d63c275be55cf2c466f90ea04f2c0
https://doi.org/10.1016/j.ejmech.2009.06.014
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4
Antiparasitic effect of a fraction enriched in tight-binding protease inhibitors isolated from the Caribbean coral Plexaura homomalla
Autor: Sebastián A. Trejo, Aymara Cabrera-Muñoz, Agustina Chidichimo, Ana Cauerhff, Maria de los Angeles Chávez-Planes, Juan José Cazzulo, Yamile González-González, Emir Salas-Sarduy
Publikováno v: Experimental parasitology. 135(3)
Malaria and American Trypanosomiasis constitute major global health problems. The continued emergence and spreading of resistant strains and the limited efficacy and/or safety of currently available therapeutic agents require a constant search for ne
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc25d83eb4923006cb8630ca63d053f8
https://pubmed.ncbi.nlm.nih.gov/24090569
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5
Molecular diversity of the Trypanosoma cruzi TcSMUG family of mucin genes and proteins
Autor: Ivana Urban, Fernán Agüero, Hai Yu, Agustina Chidichimo, Lucía Boiani Santurio, Juan Mucci, Carlos A. Buscaglia, Xi Chen
Publikováno v: The Biochemical journal. 438(2)
The surface of the protozoan Trypanosoma cruzi is covered by a dense coat of mucin-type glycoconjugates, which make a pivotal contribution to parasite protection and host immune evasion. Their importance is further underscored by the presence of >100
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04a4dfb8d48ac3bd809d3599924feddf
https://pubmed.ncbi.nlm.nih.gov/21651499
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6
Synthesis of 2-hydrazolyl-4-thiazolidinones based on multicomponent reactions and biological evaluation against Trypanosoma Cruzi
Autor: Chiara, Pizzo, Cecilia, Saiz, Alan, Talevi, Luciana, Gavernet, Pablo, Palestro, Carolina, Bellera, Luis Bruno, Blanch, Diego, Benítez, Juan J, Cazzulo, Agustina, Chidichimo, Peter, Wipf, S Graciela, Mahler
Publikováno v: Chemical biologydrug design. 77(3)
A series of 18 novel 2-hydrazolyl-4-thiazolidinones-5-carboxylic acids, amides and 5,6-α,β-unsaturated esters were synthesized, and their in vitro activity on cruzipain and T. cruzi epimastigotes was determined. Some agents show activity at 37 μm
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2419e6ddfe3a4f3b2cf15bd3dcaaa468
https://pubmed.ncbi.nlm.nih.gov/21251233
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7
ChemInform Abstract: Second Generation of 2H-Benzimidazole 1,3-Dioxide Derivatives as anti-Trypanosomatid Agents: Synthesis, Biological Evaluation, and Mode of Action Studies
Autor: Agustina Chidichimo, Hugo Cerecetto, Alicia Merlino, Mercedes González, Paola Hernández, Mariana Boiani, Lucía Boiani, Juan José Cazzulo
Publikováno v: ChemInform. 41
Exploring the influence of different substitution patterns of 2H-benzimidazole 1,3-dioxide derivatives (BzNO) we prepared fifteen new derivatives. Initially the BzNO were tested against Trypanosoma cruzi Tulahuen 2 strain epimastigote form rendering
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9e43d8cc49d9cfa9c3c205bf0898fe8f
https://doi.org/10.1002/chin.201009128
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8
New trypanocidal hybrid compounds from the association of hydrazone moieties and benzofuroxan heterocycle
Autor: Hugo Cerecetto, Mercedes González, Agustina Chidichimo, Ana M. Ferreira, Claudio Olea-Azar, Mariana Boiani, Lucía Boiani, Paola Hernández, Juan José Cazzulo, Williams Porcal
Publikováno v: Bioorganicmedicinal chemistry. 16(14)
Hybrid compounds containing hydrazones and benzofuroxan pharmacophores were designed as potential Trypanosoma cruzi-enzyme inhibitors. The majority of the designed compounds was successfully synthesized and biologically evaluated displaying remarkabl
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1dd81e49e478660def076097ea59ec9b
https://pubmed.ncbi.nlm.nih.gov/18547811
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9
In vivo anti-chagas vinylthio-, vinylsulfinyl-, and vinylsulfonylbenzofuroxan derivatives
Autor: Agustina Chidichimo, Mercedes González, Nuria E. Campillo, Juan José Cazzulo, Juan A. Páez, Hugo Cerecetto, Ana Castro, Gabriela Aguirre, Miguel Angel Basombrío, Paola Hernández, Mariana Boiani, Carolina Davies, Williams Porcal, Lucía Boiani, R Luise Krauth-Siegel
Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
New benzofuroxans were developed and studied as antiproliferative Trypanosoma cruzi agents. Compounds displayed remarkable in vitro activities against different strains, Tulahuen 2, CL Brener and Y. Its unspecific cytotoxicity was evaluated using hum
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f512368fd6740c75adfa7ba594470718
http://hdl.handle.net/10261/87146
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10
Akademický článek
Transcriptomic analysis of N-terminal mutated Trypanosoma cruzi UBP1 knockdown underlines the importance of this RNA-binding protein in parasite development.
Autor: Sabalette, Karina B.1,2 (AUTHOR), Campo, Vanina A.1,2 (AUTHOR), Sotelo-Silveira, José R.3,4 (AUTHOR), Smircich, Pablo3,4 (AUTHOR) psmircich@fcien.edu.uy, De Gaudenzi, Javier G.1,2 (AUTHOR) psmircich@fcien.edu.uy
Publikováno v: PLoS Neglected Tropical Diseases. 5/17/2024, Vol. 18 Issue 5, p1-29. 29p.
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