Independent effects of sex and stress on fructose‐induced salt‐sensitive hypertension

Autor: Autumn Brostek, Nancy J. Hong, Ronghao Zhang, Beau R. Forester, Lauren E. Barmore, Lindsey Kaydo, Nicholas Kluge, Corey Smith, Jeffrey L. Garvin, Agustin Gonzalez‐Vicente

Publikováno v: Physiological Reports, Vol 10, Iss 19, Pp n/a-n/a (2022)

Abstract Proximal tubule fructose metabolism is key to fructose‐induced hypertension, but the roles of sex and stress are unclear. We hypothesized that females are resistant to the salt‐sensitive hypertension caused by low amounts of dietary fruc

Externí odkaz: https://doaj.org/article/ce6b04dce8884acba616e8aa7eef342c

Dietary Fructose Increases the Sensitivity of Proximal Tubules to Angiotensin II in Rats Fed High-Salt Diets

Autor: Agustin Gonzalez-Vicente, Nancy J. Hong, Nianxin Yang, Pablo D. Cabral, Jessica M. Berthiaume, Fernando P. Dominici, Jeffrey L. Garvin

Publikováno v: Nutrients, Vol 10, Iss 9, p 1244 (2018)

Dietary fructose causes salt-sensitive hypertension. Proximal tubules (PTs) reabsorb 70% of the filtered NaCl. Angiotensin II (Ang II), atrial natriuretic peptide (ANP) and norepinephrine (NE) regulate this process. Although Ang II signaling blockade

Externí odkaz: https://doaj.org/article/f1d29b66469a47088337c5dbbe3c386f

Resveratrol increases nitric oxide production in the rat thick ascending limb via Ca2+/calmodulin.

Autor: Agustin Gonzalez-Vicente, Pablo D Cabral, Jeffrey L Garvin

Publikováno v: PLoS ONE, Vol 9, Iss 10, p e110487 (2014)

The thick ascending limb of the loop of Henle reabsorbs 30% of the NaCl filtered through the glomerulus. Nitric oxide (NO) produced by NO synthase 3 (NOS3) inhibits NaCl absorption by this segment. Resveratrol, a polyphenol, has beneficial cardiovasc

Externí odkaz: https://doaj.org/article/dd0cce2402e941068ddc677096d9cd9d

Integrated single-cell sequencing and histopathological analyses reveal diverse injury and repair responses in a participant with acute kidney injury: a clinical-molecular-pathologic correlation

Autor: Rajasree Menon, Andrew S. Bomback, Blue B. Lake, Christy Stutzke, Stephanie M. Grewenow, Steven Menez, Vivette D. D’Agati, Sanjay Jain, Richard Knight, Stewart H. Lecker, Isaac Stillman, Steve Bogen, Laurence H. Beck, Sushrut Waikar, Gearoid M. McMahon, Astrid Weins, Mia R. Colona, Nir Hacohen, Paul J. Hoover, Mark Aulisio, William S. Bush, Dana C. Crawford, John O'toole, Emilio Poggio, John Sedor, Leslie Cooperman, Stacey Jolly, Leal Herlitz, Jane Nguyen, Agustin Gonzalez-Vicente, Ellen Palmer, Dianna Sendrey, Carissa Vinovskis, Petter M. Bjornstad, Paul Appelbaum, Jonathan M. Barasch, Vivette D. D'Agati, Krzysztof Kiryluk, Karla Mehl, Pietro A. Canetta, Ning Shang, Olivia Balderes, Satoru Kudose, Shweta Bansal, Theodore Alexandrov, Helmut Rennke, Tarek M. El-Achkar, Yinghua Cheng, Pierre C. Dagher, Michael T. Eadon, Kenneth W. Dunn, Katherine J. Kelly, Timothy A. Sutton, Daria Barwinska, Michael J. Ferkowicz, Seth Winfree, Sharon Bledsoe, Marcelino Rivera, James C. Williams, Ricardo Melo Ferreira, Chirag R. Parikh, Celia P. Corona-Villalobos, Avi Rosenberg, Sylvia E. Rosas, Neil Roy, Mark Williams, Evren U. Azeloglu, Cijang He, Ravi Iyengar, Jens Hansen, Yuguang Xiong, Brad Rovin, Samir Parikh, John P. Shapiro, Christopher R. Anderton, Ljiljana Pasa-Tolic, Dusan Velickovic, Jessica Lukowski, George Oliver, Joseph Ardayfio, Jack Bebiak, Keith Brown, Catherine E. Campbell, John Saul, Anna Shpigel, Robert Koewler, Taneisha Campbell, Lynda Hayashi, Nichole Jefferson, Glenda V. Roberts, Roy Pinkeney, Olga Troyanskaya, Rachel Sealfon, Katherine R. Tuttle, Yury Goltsev, Kun Zhang, Zoltan G. Laszik, Garry Nolan, Patrick Boada, Minnie Sarwal, Tara Sigdel, Paul J. Lee, Rita R. Alloway, E. Steve Woodle, Heather Ascani, Ulysses G.J. Balis, Jeffrey B. Hodgin, Matthias Kretzler, Chrysta Lienczewski, Laura H. Mariani, Becky Steck, Yougqun He, Edgar Otto, Jennifer Schaub, Victoria M. Blanc, Sean Eddy, Ninive C. Conser, Jinghui Luo, Paul M. Palevsky, Matthew Rosengart, John A. Kellum, Daniel E. Hall, Parmjeet Randhawa, Mitchell Tublin, Raghavan Murugan, Michele M. Elder, James Winters, Charles E. Alpers, Kristina N. Blank, Jonas Carson, Ian H. De Boer, Ashveena L. Dighe, Jonathan Himmelfarb, Sean D. Mooney, Stuart Shankland, Kayleen Williams, Christopher Park, Frederick Dowd, Robyn L. McClelland, Stephen Daniel, Andrew N. Hoofnagle, Adam Wilcox, Kumar Sharma, Manjeri Venkatachalam, Guanshi Zhang, Annapurna Pamreddy, Hongping Ye, Richard Montellano, Robert D. Toto, Miguel Vazquez, Simon C. Lee, R. Tyler Miller, Orson W. Moe, Jose Torrealba, Nancy Wang, Asra Kermani, Kamalanathan Sambandam, Harold Park, S. Susan Hedayati, Christopher Y. Lu, Anitha Vijayan, Joseph P. Gaut, Dennis Moledina, Francis P. Wilson, Ugochukwu Ugwuowo, Tanima Arora

Publikováno v: Kidney Int

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd51674caba4cf76b6db4f600991ecc1
https://doi.org/10.1016/j.kint.2022.03.011

Single-cell transcriptional phenotypes linked to anatomical localization of fructose transporters in rat proximal tubule segments

Autor: Agustin Gonzalez-Vicente, Ronghao Zhang

Publikováno v: Physiology. 38

Kidneys of healthy individuals filter 4 to 25 g of fructose (FRU) a day, equivalent to ~10% of the filtered glucose. FRU reabsorbed by proximal tubules (PTs) is mostly used in gluconeogenesis. Elevated dietary FRU alters hormonal signaling in PTs and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0b3016a44e68a2c46cd427b603ee6f09
https://doi.org/10.1152/physiol.2023.38.s1.5725750