Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Agustin Chicas"'
Autor:
Daniel Aird, Teng Teng, Chia-Ling Huang, Ermira Pazolli, Deepti Banka, Kahlin Cheung-Ong, Cheryl Eifert, Craig Furman, Zhenhua Jeremy Wu, Michael Seiler, Silvia Buonamici, Peter Fekkes, Craig Karr, James Palacino, Eunice Park, Peter G. Smith, Lihua Yu, Yoshiharu Mizui, Markus Warmuth, Agustin Chicas, Laura Corson, Ping Zhu
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Small molecule modulators of RNA splicing have therapeutic potential in tumours bearing spliceosome mutations. Here, the authors identify BCL2 genes have differential sensitivities to SF3b-targeting splicing modulators and combination of SF3b-targeti
Externí odkaz:
https://doaj.org/article/3d3b4213a3e7400997cdfc63d11b14e8
Autor:
Teng Teng, Jennifer HC Tsai, Xiaoling Puyang, Michael Seiler, Shouyong Peng, Sudeep Prajapati, Daniel Aird, Silvia Buonamici, Benjamin Caleb, Betty Chan, Laura Corson, Jacob Feala, Peter Fekkes, Baudouin Gerard, Craig Karr, Manav Korpal, Xiang Liu, Jason T. Lowe, Yoshiharu Mizui, James Palacino, Eunice Park, Peter G. Smith, Vanitha Subramanian, Zhenhua Jeremy Wu, Jian Zou, Lihua Yu, Agustin Chicas, Markus Warmuth, Nicholas Larsen, Ping Zhu
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
A number of natural occurring small-molecule splicing modulators are known. Here, the authors combine chemogenomic, structural and biochemical methods and show that these compounds also target the spliceosome-associated protein PHF5A and propose a po
Externí odkaz:
https://doaj.org/article/bcd02552d59140f1871d75acbfffec14
Autor:
Maureen Caligiuri, Grace L. Williams, Jennifer Castro, Linda Battalagine, Erik Wilker, Lili Yao, Shawn Schiller, Angela Toms, Ping Li, Eneida Pardo, Bradford Graves, Joey Azofeifa, Agustin Chicas, Torsten Herbertz, Maria Lai, Joel Basken, Kenneth W. Wood, Qunli Xu, Sylvie M. Guichard
Publikováno v:
Targeted Oncology. 18:269-285
Autor:
Scott W. Lowe, Christopher R. Vakoc, Agustin Chicas, Vishal Thapar, Myles Fennell, Chi-Chao Chen, Jessica E. Bolden, Ozlem Aksoy, Chun-Hao Huang, Darjus F. Tschaharganeh, Matthew Camiolo, Direna Alonso-Curbelo, Jae-Seok Roe, Ana Banito, Nilgun Tasdemir
Supplementary Figure S1. Senescence-activated SASP enhancers are marked by H3K4Me1 in proliferating IMR90 cells. Supplementary Figure S2. Reproducibility analyses of biological replicates for H3K27Ac and BRD4 ChIP-Seq. Supplementary Figure S3. Enhanc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::798e0f8cd40a7d950c1af92f4da5d540
https://doi.org/10.1158/2159-8290.22531508.v1
https://doi.org/10.1158/2159-8290.22531508.v1
Autor:
Scott W. Lowe, Christopher R. Vakoc, Agustin Chicas, Vishal Thapar, Myles Fennell, Chi-Chao Chen, Jessica E. Bolden, Ozlem Aksoy, Chun-Hao Huang, Darjus F. Tschaharganeh, Matthew Camiolo, Direna Alonso-Curbelo, Jae-Seok Roe, Ana Banito, Nilgun Tasdemir
Co-culture of NK cells and P/shRen IMR90 cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fbb80042a6c8487c3efb555e5169eb7
https://doi.org/10.1158/2159-8290.22531490
https://doi.org/10.1158/2159-8290.22531490
Autor:
Scott W. Lowe, Christopher R. Vakoc, Agustin Chicas, Vishal Thapar, Myles Fennell, Chi-Chao Chen, Jessica E. Bolden, Ozlem Aksoy, Chun-Hao Huang, Darjus F. Tschaharganeh, Matthew Camiolo, Direna Alonso-Curbelo, Jae-Seok Roe, Ana Banito, Nilgun Tasdemir
Supplementary Methods, Figure Legends, References.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64e8592a7197ceec4698329b0b2a0017
https://doi.org/10.1158/2159-8290.22531505
https://doi.org/10.1158/2159-8290.22531505
Autor:
Scott W. Lowe, Christopher R. Vakoc, Agustin Chicas, Vishal Thapar, Myles Fennell, Chi-Chao Chen, Jessica E. Bolden, Ozlem Aksoy, Chun-Hao Huang, Darjus F. Tschaharganeh, Matthew Camiolo, Direna Alonso-Curbelo, Jae-Seok Roe, Ana Banito, Nilgun Tasdemir
Lists of senescence-activated and senescence-inactivated TEs and SEs.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::168b8af7ddabaf3297f8ba503c57ac62
https://doi.org/10.1158/2159-8290.22531502
https://doi.org/10.1158/2159-8290.22531502
Autor:
Gerald Gavory, Mahmoud Ghandi, Anne-Cecile d’Alessandro, Debora Bonenfant, Maciej Cabanski, Lisa Cantagallo, Agustin Chicas, Qian Chen, Anna Diesslin, Christopher King, Vittoria Massafra, Rajiv Narayan, Arnaud Osmont, Dave Peck, Carolina Perdomo Ortiz, Martin Schillo, Ambika Singh, Ralph Tiedt, Simone Tortoioli, Silvia Buonamici, Filip Janku, Owen Wallace, Bernhard Fasching
Publikováno v:
Cancer Research. 83:3449-3449
MYC transcription factors are well-established drivers of human cancers but despite being amongst the most frequently altered oncogenes, no approved therapy targeting MYC-driven tumors has been developed to date. MYC-driven cancers are known to be ad
Autor:
Zhenhua Jeremy Wu, Ermira Pazolli, Pete Smith, James Palacino, Deepti Banka, Craig Furman, Yoshiharu Mizui, Cheryl Eifert, Silvia Buonamici, Daniel Aird, Teng Teng, Craig Karr, Kahlin Cheung-Ong, Eunice Park, Agustin Chicas, Ping Zhu, Chia-Ling Huang, Markus Warmuth, Peter Fekkes, Laura Corson, Lihua Yu, Michael Seiler
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Nature Communications
Nature Communications
Dysregulation of RNA splicing by spliceosome mutations or in cancer genes is increasingly recognized as a hallmark of cancer. Small molecule splicing modulators have been introduced into clinical trials to treat solid tumors or leukemia bearing recur
Autor:
Gerald Gavory, Mahmoud Ghandi, Anne-Cecile d’Alessandro, Debora Bonenfant, Agustin Chicas, Frederic Delobel, Brad Demarco, Alexander Flohr, Christopher King, Anne-Laure Laine, Vittoria Massafra, Rajiv Narayan, Arnaud Osmont, Giorgio Ottaviani, Dave Peck, Sarah Pessa, Nooreen Rubin, Thomas Ryckmans, Martin Schillo, Ambika Singh, Simone Tortoioli, Dominico Vigil, Vladislav Zarayskiy, John Castle, Filip Janku, Owen Wallace, Silvia Buonamici, Bernhard Fasching
Publikováno v:
Cancer Research. 82:3929-3929
Myc transcription factors are well-established drivers of human cancers. However, despite being amongst the most frequently mutated, translocated and overexpressed oncogenes, no therapy targeting the Myc family members directly has been developed to