Výsledky vyhledávání - "Agusti Miralles"

Synthesis and Structure−Activity Relationship of a New Series of COX-2 Selective Inhibitors: 1,5-Diarylimidazoles

Autor: Ignasi Escamilla, José Alfón, L. A. Gomez, Elena Carceller, Julian Garcia-Rafanell, Carmen Almansa, Robert Soliva, Agusti Miralles, Alberto Fernández de Arriba, Manuel Merlos, F. L. Cavalcanti, Javier Bartroli

Publikováno v: Journal of Medicinal Chemistry. 46:3463-3475

The synthesis and the pharmacological activity of a series of 1,5-diarylimidazoles developed as potent and selective cyclooxygenase-2 (COX-2) inhibitors are described. The new compounds were evaluated both in vitro (COX-1 and COX-2 inhibition in huma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c9ca1d3a6a1e1b4dc9106f92f504d45
https://doi.org/10.1021/jm030765s

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Isolation of two CD50 (ICAM-3)-negative Jurkat T-cell clones and their application for analysis of CD50 function

Autor: Ramon Vilella, Juanjo Barcelo, C. Vilardell, Lourdes Places, J. Alberola-IIa, Manel Juan, J. Yagüe, Agust́i Miralles, Antoni Gayà, Francisco Lozano, Eduard Palou, Jordi Esparza

Publikováno v: Tissue Antigens. 51:509-519

The leukocyte differentiation antigen CD50 (intercellular adhesion molecule-3, ICAM-3), mediates cell-cell adhesion through its ligand LFA-1 and is a transducting receptor molecule during T-cell activation. Since CD50 homologues in other species have

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7be676592f587b1c5b94d771fb238c90
https://doi.org/10.1111/j.1399-0039.1998.tb02985.x

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Signaling through CD50 (ICAM-3) stimulates T lymphocyte binding to human umbilical vein endothelial cells and extracellular matrix proteins via an increase in β1 and β2 integrin function

Autor: Jordi Esparza, Ramon Vilella, Agust́i Miralles, Antoni Gayà, Maria C. Cid, Jaume Ordi, Alvaro Urbano-Márquez, Jordi Vives, Manel Juan, Jordi Yagüe

Publikováno v: European Journal of Immunology. 24:1377-1382

Regulated adhesion of T lymphocytes to antigen-presenting cells, endothelial cells and extracellular matrix proteins is crucial in T lymphocyte activation and migration to the sites of injury. In this study, we show that three monoclonal antibodies (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7164524ec567983e2568145178e14bf4
https://doi.org/10.1002/eji.1830240621

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CDw50 and ICAM-3: Two names for the same molecule

Autor: Manel Juan, R. Joachim Friedrich, John C. Cambier, Agust́i Miralles, J. Yagüe, Jordi Vives, Kerry S. Campbell, Antonin de Fougerolles, Jordi Mila, Ramon Vilella, Timothy A. Springer

Publikováno v: European Journal of Immunology. 23:1508-1512

CDw50 differentiation antigen is a molecule broadly expressed on hematopoetic cells but not on other cells. Previous experiments showed that CDw50 monoclonal antibodies (mAb) inhibited primary mixed lymphocyte culture (MLC). To understand the functio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6dd2dc4d31a388f363ba4ec5e3d0b9c
https://doi.org/10.1002/eji.1830230717

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Synthesis and SAR of a new series of COX-2-selective inhibitors: pyrazolo[1,5-a]pyrimidines

Autor: Manuel Merlos, Julian Garcia-Rafanell, F. L. Cavalcanti, J. Forn, de Arriba Af, C. Almansa, L. A. Gomez, Agusti Miralles

Publikováno v: Journal of medicinal chemistry. 44(3)

The synthesis and pharmacological activity of a series of bicyclic pyrazolo[1,5-a]pyrimidines as potent and selective cyclooxygenase-2 (COX-2) inhibitors are described. The new compounds were evaluated both in vitro (COX-1 and COX-2 inhibition in hum

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e37335b22a70499a06f9e76ab05f3244
https://pubmed.ncbi.nlm.nih.gov/11462976

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