Zobrazeno 1 - 10
of 90
pro vyhledávání: '"Agustín D. Martínez"'
Autor:
Felipe Villanelo, Peter J. Minogue, Jaime Maripillán, Mauricio Reyna-Jeldes, Joaquin Jensen-Flores, Isaac E. García, Eric C. Beyer, Tomás Pérez-Acle, Viviana M. Berthoud, Agustín D. Martínez
Publikováno v:
Biological Research, Vol 57, Iss 1, Pp 1-18 (2024)
Abstract Background Members of the β-subfamily of connexins contain an intracellular pocket surrounded by amino acid residues from the four transmembrane helices. The presence of this pocket has not previously been investigated in members of the α-
Externí odkaz:
https://doaj.org/article/06defa631d704d8c9d7c419ba703475f
Autor:
Chidinma Adanna Okolo, Jack Jonathan Maran, Amy Watts, Jaime Maripillan, Maria Harkiolaki, Agustín D. Martínez, Colin R. Green, Odunayo Omolola Mugisho
Publikováno v:
Heliyon, Vol 10, Iss 7, Pp e27888- (2024)
Non-junctional connexin43 (Cx43) plasma membrane hemichannels have been implicated in several inflammatory diseases, particularly playing a role in ATP release that triggers activation of the inflammasome. Therapies targeting the blocking of the hemi
Externí odkaz:
https://doaj.org/article/e17a063b57c24edb96e75c070ffc7e0f
Autor:
Oscar Jara, Jaime Maripillán, Fanny Momboisse, Ana María Cárdenas, Isaac E. García, Agustín D. Martínez
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 13, p 7246 (2024)
Connexins (Cxs) are transmembrane proteins that assemble into gap junction channels (GJCs) and hemichannels (HCs). Previous researches support the involvement of Rho GTPases and actin microfilaments in the trafficking of Cxs, formation of GJCs plaque
Externí odkaz:
https://doaj.org/article/9ba926a964484e14aa81a6579f880d2e
Autor:
Ana C. Abbott, Isaac E. García, Felipe Villanelo, Carolina Flores-Muñoz, Ricardo Ceriani, Jaime Maripillán, Joel Novoa-Molina, Cindel Figueroa-Cares, Tomas Pérez-Acle, Juan C. Sáez, Helmuth A. Sánchez, Agustín D. Martínez
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2023)
Some mutations in gap junction protein Connexin 26 (Cx26) lead to syndromic deafness, where hearing impairment is associated with skin disease, like in Keratitis Ichthyosis Deafness (KID) syndrome. This condition has been linked to hyperactivity of c
Externí odkaz:
https://doaj.org/article/4a2519a57af545099c4f91f689d29670
Autor:
Francisca García-Rojas, Carolina Flores-Muñoz, Odra Santander, Pamela Solis, Agustín D. Martínez, Álvaro O. Ardiles, Marco Fuenzalida
Publikováno v:
Biomolecules, Vol 13, Iss 6, p 887 (2023)
Pannexin-1 (Panx1) hemichannel is a non-selective transmembrane channel that may play important roles in intercellular signaling by allowing the permeation of ions and metabolites, such as ATP. Although recent evidence shows that the Panx1 hemichanne
Externí odkaz:
https://doaj.org/article/8ecaa2306d264fb7b9d02fe0f0e00e12
Publikováno v:
Frontiers in Neuroscience, Vol 16 (2022)
Cisplatin is a known ototoxic chemotherapy drug, causing irreversible hearing loss. Evidence has shown that cisplatin causes inner ear damage as a result of adduct formation, a proinflammatory environment and the generation of reactive oxygen species
Externí odkaz:
https://doaj.org/article/cb294471a6e24d71be9955a1139f6aeb
Autor:
Carolina Flores-Muñoz, Francisca García-Rojas, Miguel A. Pérez, Odra Santander, Elena Mery, Stefany Ordenes, Javiera Illanes-González, Daniela López-Espíndola, Arlek M. González-Jamett, Marco Fuenzalida, Agustín D. Martínez, Álvaro O. Ardiles
Publikováno v:
Cells, Vol 11, Iss 22, p 3646 (2022)
Enhanced activity and overexpression of Pannexin 1 (Panx1) channels contribute to neuronal pathologies such as epilepsy and Alzheimer’s disease (AD). The Panx1 channel ablation alters the hippocampus’s glutamatergic neurotransmission, synaptic pl
Externí odkaz:
https://doaj.org/article/b2ec816e17904dd487b66dbd7a5d8337
Autor:
Lucas Bayonés, María José Guerra-Fernández, Fernando Hinostroza, Ximena Báez-Matus, Jacqueline Vásquez-Navarrete, Luciana I. Gallo, Sergio Parra, Agustín D. Martínez, Arlek González-Jamett, Fernando D. Marengo, Ana M. Cárdenas
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 18, p 10363 (2022)
Gain-of-function mutations of dynamin-2, a mechano-GTPase that remodels membrane and actin filaments, cause centronuclear myopathy (CNM), a congenital disease that mainly affects skeletal muscle tissue. Among these mutations, the variants p.A618T and
Externí odkaz:
https://doaj.org/article/cd20d4390db047aca1d83cb8ff56bd16
Autor:
Vania A. Figueroa, Oscar Jara, Carolina A. Oliva, Marcelo Ezquer, Fernando Ezquer, Mauricio A. Retamal, Agustín D. Martínez, Guillermo A. Altenberg, Aníbal A. Vargas
Publikováno v:
Frontiers in Physiology, Vol 11 (2020)
Externí odkaz:
https://doaj.org/article/f138718c5a604835bb97a8342a8e119a
Autor:
Vania A. Figueroa, Oscar Jara, Carolina A. Oliva, Marcelo Ezquer, Fernando Ezquer, Mauricio A. Retamal, Agustín D. Martínez, Guillermo A. Altenberg, Aníbal A. Vargas
Publikováno v:
Frontiers in Physiology, Vol 10 (2020)
Connexin (Cx) proteins form gap junction channels (GJC) and hemichannels that a allow bidirectional flow of ions and metabolites between the cytoplasm and extracellular space, respectively. Under physiological conditions, hemichannels have a very low
Externí odkaz:
https://doaj.org/article/fc85ee9db0084b9fbe39cd93fda06e80