Výsledky vyhledávání - "Agustí Brugués"

Large-scale curvature sensing by directional actin flow drives cellular migration mode switching

Autor: Agustí Brugués, Benoit Ladoux, Hui Ting Ong, Xavier Trepat, Yusuke Toyama, E. G. Fedorov, Tianchi Chen, Boon Chuan Low, Andrew Callan-Jones, Raphaël Voituriez, Andrea Ravasio, Tom Shemesh

Publikováno v: Nature physics
Nature Physics
Nature Physics, Nature Publishing Group, 2019, 15 (4), pp.393-402. ⟨10.1038/s41567-018-0383-6⟩

International audience; Cell migration over heterogeneous substrates during wound healing or morphogenetic processes leads to shape changes driven by different organizations of the actin cytoskeleton and by functional changes including lamellipodial

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0911f669c54e657281ddfbab76ffbb88
https://pubmed.ncbi.nlm.nih.gov/30984281

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Forces driving epithelial wound healing

Autor: Benoit Ladoux, Xavier Trepat, Vito Conte, G. Wayne Brodland, Julien Colombelli, Mukund Gupta, Agustí Brugués, José J. Muñoz, Ester Anon, Jim H. Veldhuis

Publikováno v: Nature physics
Nature Physics
Nature Physics, Nature Publishing Group, 2014, 10 (9), pp.683-690. ⟨10.1038/nphys3040⟩
UPCommons. Portal del coneixement obert de la UPC
Universitat Politècnica de Catalunya (UPC)
ResearcherID
Recercat. Dipósit de la Recerca de Catalunya
Universitat Jaume I

A fundamental feature of multicellular organisms is their ability to self-repair wounds through the movement of epithelial cells into the damaged area. This collective cellular movement is commonly attributed to a combination of cell crawling and ‘

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db1be4721304b5f2cb70eb3e5c41d478
https://doi.org/10.1038/nphys3040

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A mechanically active heterotypic E-cadherin/N-cadherin adhesion enables fibroblasts to drive cancer cell invasion

Autor: Xavier Trepat, Anna Labernadie, Alberto Elosegui-Artola, Lorenzo Albertazzi, Víctor González-Tarragó, Anne Weston, Erik Sahai, Xavier Serra-Picamal, Agustí Brugués, Pere Roca-Cusachs, Stefanie Derzsi, Jordi Alcaraz, Esther N. Arwert, Takuya Kato

Publikováno v: Nature Cell Biology, 19(3), 224-237. Nature Publishing Group
Dipòsit Digital de la UB
Universidad de Barcelona
Recercat. Dipósit de la Recerca de Catalunya
instname
Nature Cell Biology

Cancer-associated fibroblasts (CAFs) promote tumour invasion and metastasis. We show that CAFs exert a physical force on cancer cells that enables their collective invasion. Force transmission is mediated by a heterophilic adhesion involving N-cadher

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fe5025fc5c92cb091a735173eb23ce9
https://pubmed.ncbi.nlm.nih.gov/28280267

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P-cadherin promotes collective cell migration via a Cdc42-mediated increase in mechanical forces

Autor: Agustí Brugués, Cédric Plutoni, Maïlys Le Borgne-Rochet, Stéphane Bodin, Elsa Bazellieres, Franck Comunale, Xavier Trepat, Martial Séveno, Sylvie Thuault, Nathalie Morin, Damien Planchon, Cécile Gauthier-Rouvière

Publikováno v: Journal of Cell Biology
Journal of Cell Biology, 2016, 212 (2), pp.199--217. ⟨10.1083/jcb.201505105⟩
Journal of Cell Biology, Rockefeller University Press, 2016, 212 (2), pp.199--217. ⟨10.1083/jcb.201505105⟩
Journal of Cell Biology, Rockefeller University Press, 2016, 212 (2), pp.199-217. ⟨10.1083/jcb.201505105⟩
Journal of Cell Biology, 2016, 212 (2), pp.199-217. ⟨10.1083/jcb.201505105⟩
The Journal of Cell Biology

P-cadherin induces polarization and collective cell migration through an increase in the strength and anisotropy of mechanical forces, which is mediated by the P-cadherin/β-PIX/Cdc42 axis.
Collective cell migration (CCM) is essential for organi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e145f8f0be02935bcb8bb68cf2e8a69b
https://hal.science/hal-01878038

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Traction Forces of Endothelial Cells under Slow Shear Flow

Autor: Elsa Bazellières, Agustí Brugués, Cecile M. Perrault, Damien Lacroix, Pierre Ricco, Xavier Trepat

Publikováno v: Biophysical Journal
Biophysical Journal, 2015, 109 (8), pp.1533-1536. ⟨10.1016/j.bpj.2015.08.036⟩
Biophysical Journal, Biophysical Society, 2015, 109 (8), pp.1533-1536. ⟨10.1016/j.bpj.2015.08.036⟩

Endothelial cells are constantly exposed to fluid shear stresses that regulate vascular morphogenesis, homeostasis, and disease. The mechanical responses of endothelial cells to relatively high shear flow such as that characteristic of arterial circu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b963905d515eb594a007a254316713e0
https://hal.science/hal-02406574

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Gap geometry dictates epithelial closure efficiency

Autor: Benoit Ladoux, Hui Ting Ong, Xavier Trepat, Luis Almeida, Yusuke Toyama, Agustí Brugués, Cristina Bertocchi, Andrea Ravasio, Nir S. Gov, Telmo Pereira, António Jacinto, Alexandre Kabla, Ibrahim Cheddadi, Tianchi Chen

Publikováno v: Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Nature Communications
Nature Communications, 2015, 6, pp.NATURE COMMUNICATIONS | 6:7683 | DOI: 10.1038/ncomms8683 ⟨10.1038/ncomms8683⟩
www.nature.com/naturecommunications
Nature Communications, Nature Publishing Group, 2015, 6, pp.NATURE COMMUNICATIONS | 6:7683 | DOI: 10.1038/ncomms8683 ⟨10.1038/ncomms8683⟩

Closure of wounds and gaps in tissues is fundamental for the correct development and physiology of multicellular organisms and, when misregulated, may lead to inflammation and tumorigenesis. To re-establish tissue integrity, epithelial cells exhibit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f837b28ce80a50649b4a3959ef0a0316
http://www.scopus.com/inward/record.url?scp=84937010465&partnerID=8YFLogxK

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Mechanics of epithelial closure over non-adherent environments

Autor: Chwee Teck Lim, Hiroaki Hirata, Agustí Brugués, Ibrahim Cheddadi, Tianchi Chen, Benoit Ladoux, Sri Ram Krishna Vedula, Xavier Trepat, Luis Almeida, Grégoire Peyret, Yusuke Toyama, Horacio Lopez-Menendez

Publikováno v: Nature Communications
Dipòsit Digital de la UB
Universidad de Barcelona
Nature Communications, 2015, 6, pp.Article number: 6111. ⟨10.1038/ncomms7111⟩
Nature Communications, Nature Publishing Group, 2015, 6, pp.Article number: 6111. ⟨10.1038/ncomms7111⟩
Recercat. Dipósit de la Recerca de Catalunya
instname

The closure of gaps within epithelia is crucial to maintain its integrity during biological processes such as wound healing and gastrulation. Depending on the distribution of extracellular matrix, gap closure occurs through assembly of multicellular

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::daf7e69f4743d0a00345d7c9132c876f
http://europepmc.org/articles/PMC4309897

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Epithelial bridges maintain tissue integrity during collective cell migration

Autor: Chwee Teck Lim, Sri Ram Krishna Vedula, Benoit Ladoux, Xavier Trepat, Hiroaki Hirata, Agustí Brugués, Mui Hoon Nai, Yusuke Toyama

Publikováno v: Nature Materials
Nature Materials, Nature Publishing Group, 2014, 13 (1), pp.87-96. ⟨10.1038/nmat3814⟩

International audience; The ability of skin to act as a barrier is primarily determined by the efficiency of skin cells to maintain and restore its continuity and integrity. In fact, during wound healing keratinocytes migrate collectively to maintain

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1e87031d4d36348047385b1b728a35a
https://hal.archives-ouvertes.fr/hal-00951190

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