Trypanosoma brucei aquaglyceroporin 2 is a high-affinity transporter for pentamidine and melaminophenyl arsenic drugs and the main genetic determinant of resistance to these drugs

Autor: Munday, Jane C., Eze, Anthonius A., Baker, Nicola, Glover, Lucy, Clucas, Caroline, Aguinaga Andres, David, Natto, Manal J., Teka, Ibrahim A., McDonald, Jennifer, Lee, Rebecca S., Graf, Fabrice E., Ludin, Philipp, Burchmore, Richard J. S., Turner, C. Michael R., Tait, Andy, MacLeod, Annette, Mäser, Pascal, Barrett, Michael P., Horn, David, De Koning, Harry P.

Publikováno v: Journal of Antimicrobial Chemotherapy
Journal of Antimicrobial Chemotherapy, Oxford University Press (OUP), 2014, 69 (3), pp.651-663. ⟨10.1093/jac/dkt442⟩

Objectives: Trypanosoma brucei drug transporters include the TbAT1/P2 aminopurine transporter and the high-affinity pentamidine transporter (HAPT1), but the genetic identity of HAPT1 is unknown. We recently reported that loss of T. brucei aquaglycero

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https://hal-pasteur.archives-ouvertes.fr/pasteur-03107152/file/dkt442.pdf