Selective advantage of mutant stem cells in human clonal hematopoiesis is associated with attenuated response to inflammation and aging.

Autor: Jakobsen NA; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK; Oxford Centre for Haematology, NIHR Oxford Biomedical Research Centre, Oxford, UK., Turkalj S; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK; Oxford Centre for Haematology, NIHR Oxford Biomedical Research Centre, Oxford, UK., Zeng AGX; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada., Stoilova B; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK., Metzner M; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK., Rahmig S; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK., Nagree MS; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada., Shah S; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada., Moore R; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK., Usukhbayar B; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK., Angulo Salazar M; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK., Gafencu GA; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK., Kennedy A; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK; Wellcome - MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK., Newman S; Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Botnar Research Centre, University of Oxford, Oxford, UK; Nuffield Orthopaedic Centre, Oxford University Hospitals NHS Foundation Trust, Oxford, UK., Kendrick BJL; Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Botnar Research Centre, University of Oxford, Oxford, UK; Nuffield Orthopaedic Centre, Oxford University Hospitals NHS Foundation Trust, Oxford, UK., Taylor AH; Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Botnar Research Centre, University of Oxford, Oxford, UK; Nuffield Orthopaedic Centre, Oxford University Hospitals NHS Foundation Trust, Oxford, UK., Afinowi-Luitz R; Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Botnar Research Centre, University of Oxford, Oxford, UK; Nuffield Orthopaedic Centre, Oxford University Hospitals NHS Foundation Trust, Oxford, UK., Gundle R; Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Botnar Research Centre, University of Oxford, Oxford, UK; Nuffield Orthopaedic Centre, Oxford University Hospitals NHS Foundation Trust, Oxford, UK., Watkins B; Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Botnar Research Centre, University of Oxford, Oxford, UK., Wheway K; Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Botnar Research Centre, University of Oxford, Oxford, UK., Beazley D; Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Botnar Research Centre, University of Oxford, Oxford, UK., Murison A; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada., Aguilar-Navarro AG; Unidad de Investigación Médica en Enfermedades Oncológicas, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico., Flores-Figueroa E; Unidad de Investigación Médica en Enfermedades Oncológicas, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico., Dakin SG; Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Botnar Research Centre, University of Oxford, Oxford, UK., Carr AJ; Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Botnar Research Centre, University of Oxford, Oxford, UK; Nuffield Orthopaedic Centre, Oxford University Hospitals NHS Foundation Trust, Oxford, UK., Nerlov C; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK., Dick JE; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada., Xie SZ; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada., Vyas P; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK; Oxford Centre for Haematology, NIHR Oxford Biomedical Research Centre, Oxford, UK; Department of Haematology, Oxford University Hospitals NHS Foundation Trust, Oxford, UK. Electronic address: paresh.vyas@imm.ox.ac.uk.

Publikováno v: Cell stem cell [Cell Stem Cell] 2024 Aug 01; Vol. 31 (8), pp. 1127-1144.e17. Date of Electronic Publication: 2024 Jun 24.

Human, mouse, and dog bone marrow show similar mesenchymal stromal cells within a distinctive microenvironment.

Autor: Meza-León B; Unidad de Investigación Médica en Enfermedades Oncológicas. Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, México., Gratzinger D; Department of Pathology, Stanford University School of Medicine, Stanford, CA., Aguilar-Navarro AG; Unidad de Investigación Médica en Enfermedades Oncológicas. Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, México., Juárez-Aguilar FG; Departamento de Patología, Hospital de Especialidades, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, México., Rebel VI; Department of Cell Systems & Anatomy, The University of Texas Health Science Center at San Antonio, San Antonio, TX., Torlakovic E; Saskatchewan Health Authority (SHA), Saskatoon, Saskatchewan, Canada; University of Saskatchewan, Saskatchewan, Canada., Purton LE; St. Vincent's Institute of Medical Research, Fitzroy, VIC, Australia; Department of Medicine, University of Melbourne, Parkville, VIC, Australia., Dorantes-Acosta EM; Biobanco de Investigación en Células Leucémicas, Hospital Infantil de México Federico Gómez, Mexico City, México., Escobar-Sánchez A; Departamento de Patología, Hospital infantil de México Federico Gómez, Mexico City, México., Dick JE; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada., Flores-Figueroa E; Unidad de Investigación Médica en Enfermedades Oncológicas. Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, México; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada. Electronic address: eugenia.flores-figueroa@uhnresearch.ca.

Publikováno v: Experimental hematology [Exp Hematol] 2021 Aug; Vol. 100, pp. 41-51. Date of Electronic Publication: 2021 Jul 03.

Rosiglitazone, a Ligand to PPAR γ , Improves Blood Pressure and Vascular Function through Renin-Angiotensin System Regulation.

Autor: Sánchez-Aguilar M; Department of Pharmacology, Instituto Nacional de Cardiología Ignacio Chávez, Juan Badiano No. 1, Col Sección XVI, Tlalpan, 14080 México, Ciudad de México, Mexico.; Department of Molecular Medicine, Laboratory of Computational Biophysics and Biochemistry, ENMH-IPN, Guillermo Massieu Helguera No. 239, Fracc. La Escalera Ticoman, Gustavo A. Madero, 07320, Ciudad de México, Mexico., Ibarra-Lara L; Department of Pharmacology, Instituto Nacional de Cardiología Ignacio Chávez, Juan Badiano No. 1, Col Sección XVI, Tlalpan, 14080 México, Ciudad de México, Mexico., Del Valle-Mondragón L; Department of Pharmacology, Instituto Nacional de Cardiología Ignacio Chávez, Juan Badiano No. 1, Col Sección XVI, Tlalpan, 14080 México, Ciudad de México, Mexico., Rubio-Ruiz ME; Department of Physiology, Instituto Nacional de Cardiología Ignacio Chávez, Juan Badiano No. 1, Col Sección XVI, Tlalpan, 14080 México, Ciudad de México, Mexico., Aguilar-Navarro AG; Department of Molecular Medicine, Laboratory of Computational Biophysics and Biochemistry, ENMH-IPN, Guillermo Massieu Helguera No. 239, Fracc. La Escalera Ticoman, Gustavo A. Madero, 07320, Ciudad de México, Mexico., Zamorano-Carrillo A; Department of Molecular Medicine, Laboratory of Computational Biophysics and Biochemistry, ENMH-IPN, Guillermo Massieu Helguera No. 239, Fracc. La Escalera Ticoman, Gustavo A. Madero, 07320, Ciudad de México, Mexico., Ramírez-Ortega MDC; Department of Pharmacology, Instituto Nacional de Cardiología Ignacio Chávez, Juan Badiano No. 1, Col Sección XVI, Tlalpan, 14080 México, Ciudad de México, Mexico., Pastelín-Hernández G; Department of Pharmacology, Instituto Nacional de Cardiología Ignacio Chávez, Juan Badiano No. 1, Col Sección XVI, Tlalpan, 14080 México, Ciudad de México, Mexico., Sánchez-Mendoza A; Department of Pharmacology, Instituto Nacional de Cardiología Ignacio Chávez, Juan Badiano No. 1, Col Sección XVI, Tlalpan, 14080 México, Ciudad de México, Mexico.

Publikováno v: PPAR research [PPAR Res] 2019 Feb 03; Vol. 2019, pp. 1371758. Date of Electronic Publication: 2019 Feb 03 (Print Publication: 2019).