Zobrazeno 1 - 10
of 127
pro vyhledávání: '"Agueda Rostagno"'
Publikováno v:
Translational Neurodegeneration, Vol 11, Iss 1, Pp 1-18 (2022)
Abstract Background The molecular heterogeneity of Alzheimer’s amyloid-β (Aβ) deposits extends well beyond the classic Aβ1-40/Aβ1-42 dichotomy, substantially expanded by multiple post-translational modifications that increase the proteome diver
Externí odkaz:
https://doaj.org/article/0df3c23e6c79457da2afc78f89b6eb98
Publikováno v:
Alzheimer’s Research & Therapy, Vol 12, Iss 1, Pp 1-22 (2020)
Abstract Background Mounting evidence points to a crucial role of amyloid-β (Aβ) in the pathophysiology of Alzheimer’s disease (AD), a disorder in which brain glucose hypometabolism, downregulation of central elements of phosphorylation pathways,
Externí odkaz:
https://doaj.org/article/25458671e1c34b8389197f2877e8893c
Autor:
Agueda Rostagno, Miguel Calero, Janice L. Holton, Tamas Revesz, Tammaryn Lashley, Jorge Ghiso
Publikováno v:
Neurobiology of Disease, Vol 158, Iss , Pp 105452- (2021)
Familial British and Danish dementias (FBD and FDD) share striking neuropathological similarities with Alzheimer's disease (AD), including intraneuronal neurofibrillary tangles as well as parenchymal and vascular amyloid deposits. Multiple amyloid as
Externí odkaz:
https://doaj.org/article/54b457bb84c94036aa620a214cf29cfe
Autor:
Mandar Dave, Abul B.M.M.K. Islam, Roderick V. Jensen, Agueda Rostagno, Jorge Ghiso, Ashok R. Amin
Publikováno v:
Genomics, Proteomics & Bioinformatics, Vol 15, Iss 6, Pp 339-351 (2017)
The differential expression of two closelyassociated cyclooxygenase isozymes, COX-1 and COX-2, exhibited functions beyond eicosanoid metabolism. We hypothesized that COX-1 or COX-2 knockout lung fibroblasts may display altered protein profiles which
Externí odkaz:
https://doaj.org/article/23dad21e7c894340a7a649039ec7ecdd
Publikováno v:
Alzheimer’s Research & Therapy, Vol 12, Iss 1, Pp 1-2 (2020)
After the publication of this article [1], we became aware that there were errors in Figs. 4 and 31.
Externí odkaz:
https://doaj.org/article/0b44c204ea084ec4a40b06c9176b69d8
Autor:
Silvia Fossati, Patrizia Giannoni, Maria E. Solesio, Sarah L. Cocklin, Erwin Cabrera, Jorge Ghiso, Agueda Rostagno
Publikováno v:
Neurobiology of Disease, Vol 86, Iss , Pp 29-40 (2016)
Mitochondrial dysfunction has been recognized as an early event in Alzheimer's disease (AD) pathology, preceding and inducing neurodegeneration and memory loss. The presence of cytochrome c (CytC) released from the mitochondria into the cytoplasm is
Externí odkaz:
https://doaj.org/article/165bbc7be0b74a2fb820d193492ef648
Publikováno v:
Neurobiology of Disease, Vol 85, Iss , Pp 130-143 (2016)
Familial Danish Dementia (FDD), an early-onset non-amyloid-β (Aβ) cerebral amyloidosis, is neuropathologically characterized by widespread cerebral amyloid angiopathy, parenchymal amyloid and preamyloid deposits, as well as neurofibrillary degenera
Externí odkaz:
https://doaj.org/article/564c339b8d1546c580c54ffe8d6b2459
Autor:
Farron Lynn McIntee, Patrizia Giannoni, Steven Blais, George Sommer, Thomas Neubert, Agueda Rostagno, Jorge Ghiso
Publikováno v:
Frontiers in Aging Neuroscience, Vol 8 (2016)
Amyloid β (Aβ) is the major constituent of the brain deposits found in parenchymal plaques and cerebral blood vessels of patients with Alzheimer’s disease (AD). Several lines of investigation support the notion that synaptic pathology, one of the
Externí odkaz:
https://doaj.org/article/c60c3f1ce55d4de2884899e386994296
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2466
Affinity chromatography has, for many years, been at the research forefront as one of the simplest although highly versatile techniques capable of identifying biologically relevant protein-protein interactions. In the field of amyloid disorders, the
Publikováno v:
The FASEB Journal. 36