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pro vyhledávání: '"Agueda, González-Rodríguez"'
Autor:
Eva Baquedano, Emma Burgos-Ramos, Sandra Canelles, Agueda González-Rodríguez, Julie A. Chowen, Jesús Argente, Vicente Barrios, Angela M. Valverde, Laura M. Frago
Publikováno v:
Disease Models & Mechanisms, Vol 9, Iss 5, Pp 573-583 (2016)
Insulin receptor substrate-2-deficient (IRS2−/−) mice are considered a good model to study the development of diabetes because IRS proteins mediate the pleiotropic effects of insulin-like growth factor-I (IGF-I) and insulin on metabolism, mitogen
Externí odkaz:
https://doaj.org/article/94b42fdba4da423b984672a4056c1e5d
Autor:
Agueda, González-Rodríguez, Jose A, Más-Gutierrez, Mercedes, Mirasierra, Antonio, Fernandez-Pérez, Yong J, Lee, Hwi J, Ko, Jason K, Kim, Eduardo, Romanos, Jose M, Carrascosa, Manuel, Ros, Mario, Vallejo, Cristina M, Rondinone, Angela M, Valverde
Publikováno v:
Aging cell. 11(2)
Protein tyrosine phosphatase 1B (PTP1B) is a negative regulator of insulin signaling and a therapeutic target for type 2 diabetes (T2DM). In this study, we have evaluated the role of PTP1B in the development of aging-associated obesity, inflammation,