Pharmacological inhibition of histamine N-methyltransferase extends wakefulness and suppresses cataplexy in a mouse model of narcolepsy.

Autor: Naganuma F; Department of Neuropharmacology, Hokkaido University Graduate School of Medicine, Hokkaido, Japan.; Department of Pharmacology, Tohoku University Graduate School of Medicine, Miyagi, Japan.; Division of Pharmacology, Faculty of Medicine, Tohoku Medical and Pharmaceutical University, Miyagi, Japan., Girgin B; Department of Neuropharmacology, Hokkaido University Graduate School of Medicine, Hokkaido, Japan., Agu ABS; Department of Neuropharmacology, Hokkaido University Graduate School of Medicine, Hokkaido, Japan., Hirano K; Department of Neuropharmacology, Hokkaido University Graduate School of Medicine, Hokkaido, Japan., Nakamura T; Division of Pharmacology, Faculty of Medicine, Tohoku Medical and Pharmaceutical University, Miyagi, Japan.; Division of Bioregulatory Pharmacology, Department of Pharmacology, Iwate Medical University, Iwate, Japan., Yanai K; Cyclotron and Radioisotope Center, Tohoku University, Miyagi, Japan., Vetrivelan R; Department of Neurology, Beth Israel Deaconess Medical Center and Division of Sleep Medicine, Harvard Medical School, Boston, MA, USA., Mochizuki T; International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, Ibaraki, Japan., Yanagisawa M; International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, Ibaraki, Japan., Yoshikawa T; Department of Neuropharmacology, Hokkaido University Graduate School of Medicine, Hokkaido, Japan.; Department of Pharmacology, Tohoku University Graduate School of Medicine, Miyagi, Japan.

Publikováno v: Sleep [Sleep] 2024 Oct 23. Date of Electronic Publication: 2024 Oct 23.