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pro vyhledávání: '"Agostino Rodeo Sica"'
Autor:
Tonia Buonomo, Nicola Esposito, Susan Branford, Timothy P. Hughes, Agostino Rodeo Sica, Deborah L. White, Margherita Ruoppolo, Jerald P. Radich, Marco Picardi, Fabrizio Pane, Giuseppe Saglio, Thea Kalebic, Anna Lucia Peluso, Luigi Del Vecchio, Concetta Quintarelli, Irene Colavita, Junia V. Melo, Rosanna Martinelli, Domenico Russo, Giovanni Martinelli, Luigia Luciano
Publikováno v:
Blood. 118:3634-3644
We prove that the SH2-containing tyrosine phosphatase 1 (SHP-1) plays a prominent role as resistance determinant of imatinib (IMA) treatment response in chronic myelogenous leukemia cell lines (sensitive/KCL22-S and resistant/KCL22-R). Indeed, SHP-1