Zobrazeno 1 - 10
of 136
pro vyhledávání: '"Agostino, Marrazzo"'
Autor:
Daniele Zampieri, Maurizio Romano, Sara Fortuna, Emanuele Amata, Maria Dichiara, Giuseppe Cosentino, Agostino Marrazzo, Maria Grazia Mamolo
Publikováno v:
Molecules, Vol 29, Iss 11, p 2697 (2024)
Sigma receptors (SRs), including SR1 and SR2 subtypes, have attracted increasing interest in recent years due to their involvement in a wide range of activities, including the modulation of opioid analgesia, neuroprotection, and potential anticancer
Externí odkaz:
https://doaj.org/article/519e60ae8b054b2ea4bc975396ccff15
Autor:
Giuliana Costanzo, Rita Turnaturi, Carmela Parenti, Salvatore Spoto, Silvia Piana, Maria Dichiara, Chiara Zagni, Anna Rita Galambos, Nariman Essmat, Agostino Marrazzo, Emanuele Amata, Mahmoud Al-Khrasani, Lorella Pasquinucci
Publikováno v:
Molecules, Vol 28, Iss 12, p 4827 (2023)
In this work, we report on the in vitro and in vivo pharmacological properties of LP1 analogs to complete the series of structural modifications aimed to generate compounds with improved analgesia. To do that, the phenyl ring in the N-substituent of
Externí odkaz:
https://doaj.org/article/e704a326999c4ff3b128293aa8a6660a
Autor:
Daniele Zampieri, Antonella Calabretti, Maurizio Romano, Sara Fortuna, Simona Collina, Emanuele Amata, Maria Dichiara, Agostino Marrazzo, Maria Grazia Mamolo
Publikováno v:
Molecules, Vol 28, Iss 8, p 3431 (2023)
Neurodegeneration is a slow and progressive loss of neuronal cells or their function in specific regions of the brain or in the peripheral system. Among several causes responsible for the most common neurodegenerative diseases (NDDs), cholinergic/dop
Externí odkaz:
https://doaj.org/article/fb0d427f24c744a8b1218207b459d543
Autor:
Annamaria Fidilio, Margherita Grasso, Rita Turnaturi, Giuseppe Caruso, Federica Maria Spitale, Nunzio Vicario, Rosalba Parenti, Salvatore Spoto, Nicolò Musso, Agostino Marrazzo, Santina Chiechio, Filippo Caraci, Lorella Pasquinucci, Carmela Parenti
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Neuropathic pain is one of the most disabling forms of chronic pain and it is characterized by hyperalgesia and allodynia linked to an aberrant processing of pain transmission and to neuroinflammation. Transforming growth factor-β1 (TGF-β1) is an a
Externí odkaz:
https://doaj.org/article/2a619d81aa474855b2154eabc90b5207
Autor:
Rita Turnaturi, Santina Chiechio, Lorella Pasquinucci, Salvatore Spoto, Giuliana Costanzo, Maria Dichiara, Silvia Piana, Margherita Grasso, Emanuele Amata, Agostino Marrazzo, Carmela Parenti
Publikováno v:
Molecules, Vol 27, Iss 16, p 5135 (2022)
Although opioids and nonsteroidal anti-inflammatory drugs (NSAIDs) are the most common drugs used in persistent pain treatment; they have shown many side effects. The development of new analgesics endowed with mu opioid receptor/delta opioid receptor
Externí odkaz:
https://doaj.org/article/fa89ceaf72aa4b489cc7b67a2f3fc901
Autor:
Valeria Ciaffaglione, Valeria Consoli, Sebastiano Intagliata, Agostino Marrazzo, Giuseppe Romeo, Valeria Pittalà, Khaled Greish, Luca Vanella, Giuseppe Floresta, Antonio Rescifina, Loredana Salerno, Valeria Sorrenti
Publikováno v:
Molecules, Vol 27, Iss 10, p 3220 (2022)
This paper reports on a novel series of tyrosine kinase inhibitors (TKIs) potentially useful for the treatment of chronic myeloid leukemia (CML). The newly designed and synthesized compounds are structurally related to nilotinib (NIL), a second-gener
Externí odkaz:
https://doaj.org/article/04d5594b9bda4cd4bfd90b74c5595aec
Autor:
Nunzio Vicario, Simona Denaro, Rita Turnaturi, Lucia Longhitano, Federica Maria Spitale, Salvatore Spoto, Agostino Marrazzo, Agata Zappalà, Daniele Tibullo, Giovanni Li Volti, Santina Chiechio, Lorella Pasquinucci, Rosalba Parenti, Carmela Parenti
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 11, p 5864 (2022)
Chronic neuropathic pain emerges from either central or peripheral lesions inducing spontaneous or amplified responses to non-noxious stimuli. Despite different pharmacological approaches to treat such a chronic disease, neuropathic pain still repres
Externí odkaz:
https://doaj.org/article/c23c60d891384fecb919d120f421c4b7
Autor:
Emanuele Amata, Agostino Marrazzo, Maria Dichiara, Maria N. Modica, Loredana Salerno, Orazio Prezzavento, Giovanni Nastasi, Antonio Rescifina, Giuseppe Romeo, Valeria PittalÃ
Publikováno v:
Data in Brief, Vol 15, Iss , Pp 281-299 (2017)
The data have been obtained from the Heme Oxygenase Database (HemeOxDB) and refined according to the 2D-QSAR requirements. These data provide information about a set of more than 380 Heme Oxygenase-1 (HO-1) inhibitors. The development of the 2D-QSAR
Externí odkaz:
https://doaj.org/article/866e9a69d942462180b8d0332c324c05
Autor:
Pasquinucci, Giuliana Costanzo, Rita Turnaturi, Carmela Parenti, Salvatore Spoto, Silvia Piana, Maria Dichiara, Chiara Zagni, Anna Rita Galambos, Nariman Essmat, Agostino Marrazzo, Emanuele Amata, Mahmoud Al-Khrasani, Lorella
Publikováno v:
Molecules; Volume 28; Issue 12; Pages: 4827
In this work, we report on the in vitro and in vivo pharmacological properties of LP1 analogs to complete the series of structural modifications aimed to generate compounds with improved analgesia. To do that, the phenyl ring in the N-substituent of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=multidiscipl::b482d84214d799ae346fe4ba0c812efc
Autor:
Antonio Rescifina, Giuseppe Floresta, Agostino Marrazzo, Carmela Parenti, Orazio Prezzavento, Giovanni Nastasi, Maria Dichiara, Emanuele Amata
Publikováno v:
Data in Brief, Vol 13, Iss , Pp 514-535 (2017)
The data have been obtained from the Sigma-2 Receptor Selective Ligands Database (S2RSLDB) and refined according to the QSAR requirements. These data provide information about a set of 548 Sigma-2 (σ2) receptor ligands selective over Sigma-1 (σ1) r
Externí odkaz:
https://doaj.org/article/59aa3cfb9e8e4e33a7b014ee4e3f2a59