Výsledky vyhledávání - "Agostina Arias"

Akademický článek

Regulation of multidrug resistance proteins by genistein in a hepatocarcinoma cell line: impact on sorafenib cytotoxicity.

Autor: Juan Pablo Rigalli, Nadia Ciriaci, Agostina Arias, María Paula Ceballos, Silvina Stella Maris Villanueva, Marcelo Gabriel Luquita, Aldo Domingo Mottino, Carolina Inés Ghanem, Viviana Alicia Catania, María Laura Ruiz

Publikováno v: PLoS ONE, Vol 10, Iss 3, p e0119502 (2015)

Hepatocellular carcinoma (HCC) is the fifth most frequent cancer worldwide. Sorafenib is the only drug available that improves the overall survival of HCC patients. P-glycoprotein (P-gp), Multidrug resistance-associated proteins 2 and 3 (MRP2 and 3)

Externí odkaz: https://doaj.org/article/f67cc32f5d164bbe83f394190ac70a9b

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Akademický článek

Regulation of biotransformation systems and ABC transporters by benznidazole in HepG2 cells: involvement of pregnane X-receptor.

Autor: Juan P Rigalli, Virginia G Perdomo, Marcelo G Luquita, Silvina S M Villanueva, Agostina Arias, Dirk Theile, Johanna Weiss, Aldo D Mottino, María L Ruiz, Viviana A Catania

Publikováno v: PLoS Neglected Tropical Diseases, Vol 6, Iss 12, p e1951 (2012)

BACKGROUND: Benznidazole (BZL) is the only antichagasic drug available in most endemic countries. Its effect on the expression and activity of drug-metabolizing and transporter proteins has not been studied yet. METHODOLOGY/PRINCIPAL FINDINGS: Expres

Externí odkaz: https://doaj.org/article/7653d70c06d3481fb0be018f385014c5

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Acute regulation of multidrug resistance-associated protein 2 localization and activity by cAMP and estradiol-17beta-D-glucuronide in rat intestine and Caco-2 cells

Autor: Guillermo Nicolás Tocchetti, Maite Rocío Arana, María Laura Ruiz, Aldo D. Mottino, Agostina Arias, Juan Pablo Rigalli, Felipe Zecchinati, Silvina Stella Maris Villanueva, Camila Juliana Domínguez

Publikováno v: Archives of Toxicology, 92, 2, pp. 777-788
Archives of Toxicology, 92, 777-788

Multidrug resistance-associated protein 2 (MRP2) is an ATP-dependent transporter expressed at the brush border membrane of the enterocyte that confers protection against absorption of toxicants from foods or bile. Acute, short-term regulation of inte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de61f06a00dbbc0b9e50d444156d6728
https://doi.org/10.1007/s00204-017-2092-9

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Coordinated induction of GST and MRP2 by cAMP in Caco-2 cells: Role of protein kinase A signaling pathway and toxicological relevance

Autor: Guillermo Nicolás Tocchetti, Maite Rocío Arana, Juan Pablo Rigalli, Pablo Domizi, Silvina Stella Maris Villanueva, Marcelo G. Luquita, María Laura Ruiz, Aldo D. Mottino, Claudia Banchio, Agostina Arias

Publikováno v: Toxicology and Applied Pharmacology. 287:178-190

The cAMP pathway is a universal signaling pathway regulating many cellular processes including metabolic routes, growth and differentiation. However, its effects on xenobiotic biotransformation and transport systems are poorly characterized. The effe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e373f154f66ee9ce594ab0dd2fd45ad
https://doi.org/10.1016/j.taap.2015.06.003

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Regulation of expression and activity of multidrug resistance proteins MRP2 and MDR1 by estrogenic compounds in Caco-2 cells. Role in prevention of xenobiotic-induced cytotoxicity

Autor: Viviana A. Catania, Agostina Arias, Juan Pablo Rigalli, Marcelo G. Luquita, Mary Vore, Virginia Gabriela Perdomo, Aldo D. Mottino, María Laura Ruiz, Silvina Stella Maris Villanueva

Publikováno v: Toxicology. 320:46-55

ABC transporters including MRP2, MDR1 and BCRP play a major role in tissue defense. Epidemiological and experimental studies suggest a cytoprotective role of estrogens in intestine,though the mechanism remains poorly understood. We evaluated whether

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::046c214d13e1b4ad04c8f2867f7e3ddc
https://doi.org/10.1016/j.tox.2014.03.007

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Acetaminophen-induced stimulation of MDR1 expression and activity in rat intestine and in LS 174T human intestinal cell line

Autor: Silvina Stella Maris Villanueva, Alba G. Blazquez, Aldo D. Mottino, Jose J.G. Marin, Modesto C. Rubio, Griselda Delli Carpini, Analia Novak, Carolina Inés Ghanem, Agostina Arias

Publikováno v: Biochemical Pharmacology. 81:244-250

The well-known analgesic and antipyretic drug N-acetyl-p-aminophenol (acetaminophen; APAP) has been previously reported to affect MDR1 expression in rat liver. In this study, we have investigated the effect of subtoxic doses of APAP on MDR1 expressio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c75ed7cddbac31d853d67cdaa86ee275
https://doi.org/10.1016/j.bcp.2010.10.006

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Induction of intestinal multidrug resistance-associated protein 2 (Mrp2) by spironolactone in rats

Autor: María Laura Ruiz, Marcelo G. Luquita, Juan Pablo Rigalli, Aldo D. Mottino, José M. Pellegrino, Enrique J. Sánchez Pozzi, Viviana A. Catania, Silvina Stella Maris Villanueva, Agostina Arias

Publikováno v: European Journal of Pharmacology. 623:103-106

The effect of spironolactone (SL) pretreatment (200micromol/kg b.w./day, 3 consecutive days) on intestinal multidrug resistance-associated protein 2 (Mrp2) was evaluated in rats. A significant increase in protein levels in upper regions of small inte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7bbd3fe1223168109b9914ff5a16edc
https://doi.org/10.1016/j.ejphar.2009.09.014

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Regulation of Expression and Activity of Rat Intestinal Multidrug Resistance-Associated Protein 2 by Cholestatic Estrogens

Autor: Viviana A. Catania, María L. Ruiz, Marcelo G. Luquita, Luis M. Veggi, Aldo D. Mottino, Agostina Arias, Mary Vore, Silvina Stella Maris Villanueva, José M. Pellegrino

Publikováno v: Drug Metabolism and Disposition. 37:1277-1285

The effect of the cholestatic estrogens ethynylestradiol (EE) and estradiol 17beta-D-glucuronide (E2-17G) on expression and activity of intestinal multidrug resistant-associated protein 2 (Mrp2, Abcc2) was studied in rats. Expression and localization

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bec45ae536a8f66861773239f7702e5a
https://doi.org/10.1124/dmd.108.025643

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Regulation of Multidrug Resistance Proteins by Genistein in a Hepatocarcinoma Cell Line: Impact on Sorafenib Cytotoxicity

Autor: Carolina Inés Ghanem, Marcelo G. Luquita, Aldo D. Mottino, María Paula Ceballos, María Laura Ruiz, Silvina Stella Maris Villanueva, Viviana A. Catania, Juan Pablo Rigalli, Agostina Arias, Nadia Ciriaci

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
PLoS ONE, Vol 10, Iss 3, p e0119502 (2015)
PLoS ONE

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e16c4343f246714938d4ec2539a9097
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0119502

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Estrogen receptor- mediates human multidrug resistance associated protein 3 induction by 17-ethynylestradiol. Role of activator protein-1

Autor: Silvina Stella Maris Villanueva, Viviana A. Catania, Agostina Arias, Claudia Banchio, María Laura Ruiz, Juan Pablo Rigalli, Aldo D. Mottino, Mary Vore

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

Previously, we have demonstrated that 17α-ethynylestradiol (EE) induces rat multidrug-resistance associated protein 3 (Mrp3, Abcc3) expression transcriptionally through estrogen receptor-α (ER-α) activation. We explored the effect of EE on MRP3 ex

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26c175f5be5dcf890098100b43597e29
http://www.sciencedirect.com/science/article/pii/S0006295213003511

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