Zobrazeno 1 - 10
of 325
pro vyhledávání: '"Agnieszka Wozniak"'
Autor:
Szymon Macioszek, Danuta Dudzik, Rafał Bartoszewski, Tomasz Stokowy, Diether Lambrechts, Bram Boeckx, Agnieszka Wozniak, Patrick Schöffski, Michał J. Markuszewski
Publikováno v:
Translational Oncology, Vol 30, Iss , Pp 101632- (2023)
Background: Although imatinib is a well-established first-line drug for treating a vast majority of gastrointestinal stromal tumours (GIST), GISTs acquire secondary resistance during therapy. Multi-omics approaches provide an integrated perspective t
Externí odkaz:
https://doaj.org/article/45e412c3a749489d854a7e0c278adf19
Autor:
Marine Delvaux, Perrine Hagué, Ligia Craciun, Agnieszka Wozniak, Pieter Demetter, Patrick Schöffski, Christophe Erneux, Jean-Marie Vanderwinden
Publikováno v:
Cancers, Vol 14, Iss 20, p 5050 (2022)
GISTs are sarcomas of the gastrointestinal tract often associated with gain-of-function mutations in KIT or PDGFRA receptor genes. While most GISTs initially respond to tyrosine kinase inhibitors, relapses due to acquired resistance frequently occur.
Externí odkaz:
https://doaj.org/article/9349b19713554df9952f6de5830df4bd
Autor:
Britt Van Renterghem, Agnieszka Wozniak, Patricia Garrido Castro, Patrick Franken, Nora Pencheva, Raf Sciot, Patrick Schöffski
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 14, p 7493 (2022)
Doxorubicin (doxo) remains the standard of care for patients with advanced soft tissue sarcoma (STS), even though response rates to doxo are only around 14% to 18%. We evaluated enapotamab vedotin (EnaV), an AXL-specific antibody-drug conjugate (ADC)
Externí odkaz:
https://doaj.org/article/550be6ca87124ec9a8536a657f92eede
Autor:
Yannick Wang, Agnieszka Wozniak, Jasmien Cornillie, Pablo Avilés, Maria Debiec-Rychter, Raf Sciot, Patrick Schöffski
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 13, p 7454 (2022)
A clinically relevant subset of patients with soft tissue sarcoma presents with either locally advanced or upfront metastatic disease, or will develop distant metastases over time, despite successful treatment of their primary tumour. The currently a
Externí odkaz:
https://doaj.org/article/d83220ebb31d4bffb02353a940d03acf
Autor:
Patrick Schöffski, Yemarshet Gebreyohannes, Thomas Van Looy, Paul Manley, Joseph D. Growney, Matthew Squires, Agnieszka Wozniak
Publikováno v:
Biomedicines, Vol 10, Iss 5, p 1135 (2022)
Advanced gastrointestinal stromal tumors (GIST) are typically treated with tyrosine kinase inhibitors, and imatinib is the most commonly used standard of care in first line treatments. The use of this and other tyrosine kinase inhibitors is associate
Externí odkaz:
https://doaj.org/article/484920ba396f47a9b8dfc3ffc6188718
Autor:
Che-Jui Lee, Elodie Modave, Bram Boeckx, Bernd Kasper, Steinar Aamdal, Michael G. Leahy, Piotr Rutkowski, Sebastian Bauer, Maria Debiec-Rychter, Raf Sciot, Diether Lambrechts, Agnieszka Wozniak, Patrick Schöffski
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 10, p 5689 (2022)
Alveolar soft part sarcoma (ASPS) is a rare subtype of soft tissue sarcoma characterized by an unbalanced translocation, resulting in ASPSCR1-TFE3 fusion that transcriptionally upregulates MET expression. The European Organization for Research and Tr
Externí odkaz:
https://doaj.org/article/51327262e6074023b7fafe99638db58e
Autor:
Jasmien Cornillie, Agnieszka Wozniak, Britt Van Renterghem, Nathalie Van Winkel, Jasmien Wellens, Yemarshet K. Gebreyohannes, Maria Debiec-Rychter, Raf Sciot, Daphne Hompes, Patrick Schöffski
Publikováno v:
BMC Cancer, Vol 19, Iss 1, Pp 1-12 (2019)
Abstract Background Soft tissue sarcoma (STS) comprises a family of rare, heterogeneous tumors of mesenchymal origin. Single-agent doxorubicin remains the first-line standard-of-care treatment for advanced and inoperable STS, but response rates are o
Externí odkaz:
https://doaj.org/article/04a447b35404461fae43948d5d350cc7
Autor:
Britt Van Renterghem, Agnieszka Wozniak, Ludovica Tarantola, Andrea Casazza, Jasmien Wellens, Madita Nysen, Ulla Vanleeuw, Che-Jui Lee, Geert Reyns, Raf Sciot, Nele Kindt, Patrick Schöffski
Publikováno v:
Biomedicines, Vol 10, Iss 4, p 862 (2022)
Despite poor response rates and dose-limiting cardiotoxicity, doxorubicin (doxo) remains the standard-of-care for patients with advanced soft tissue sarcoma. We evaluated the efficacy of two tetrapeptidic doxo prodrugs (PhAc-ALGP-Dox or CBR-049 and C
Externí odkaz:
https://doaj.org/article/a512cdb2502b47388dd8c6090096ed70
Autor:
Che-Jui Lee, Agnieszka Wozniak, Thomas Van Cann, Iris Timmermans, Jasmien Wellens, Ulla Vanleeuw, Inge H. Briaire-de Bruijn, Christian Britschgi, Judith V. M. G. Bovée, Inti Zlobec, Raf Sciot, Patrick Schöffski
Publikováno v:
Sarcoma, Vol 2021 (2021)
Soft tissue sarcoma (STS) is a heterogeneous family of rare mesenchymal tumors, characterized by histopathological and molecular diversity. Tissue microarray (TMA) is a tool that allows performing research in orphan diseases in a more efficient and c
Externí odkaz:
https://doaj.org/article/75dc8183195b42d8933554d4f066ec96
Autor:
Yannick Wang, Agnieszka Wozniak, Jasmien Wellens, Yemarshet K. Gebreyohannes, Maria Jose Guillén, Pablo M. Avilés, Maria Debiec-Rychter, Raf Sciot, Patrick Schöffski
Publikováno v:
Translational Oncology, Vol 13, Iss 11, Pp 100832- (2020)
The majority of patients with gastrointestinal stromal tumors (GIST) eventually become resistant with time due to secondary mutations in the driver receptor tyrosine kinase. Novel treatments that do not target these receptors may therefore be prefera
Externí odkaz:
https://doaj.org/article/5bd45724a5e8427981d92dd9f2e59aa0