Antiaging hormone Klotho derived from renal distal-convolution regulates calcium but not phosphate homeostasis

Autor: Ganesh Pathare, Klaudia Kopper, Adisa Trnjanin, Dominique Loffing-Cueni, Agnieszka Wengi, Johannes Loffing

Publikováno v: Physiology. 38

Soluble-Klotho (sKl) is the shed ectodomain of the transmembrane protein-Klotho (mKl) that exhibits pleiotropic actions, including lifespan extension, mineral metabolism, slowing-down kidney diseases and cardioprotection. The sKl is derived from the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2b48e0ac0aba09a3f0bd3170da5849e9
https://doi.org/10.1152/physiol.2023.38.s1.5734567

A five amino acids deletion in NKCC2 of C57BL/6 mice affects analysis of NKCC2 phosphorylation but does not impact kidney function

Autor: Viktoria Fisi, Agnieszka Wengi, Dominique Loffing-Cueni, Robert A. Fenton, Marta Mariniello, James A. McCormick, Sandra Moser, Yuya Sugano, Johannes Loffing, Lena Lindtoft Rosenbaek

Publikováno v: Moser, S, Sugano, Y, Wengi, A, Fisi, V, Lindtoft Rosenbaek, L, Mariniello, M, Loffing-Cueni, D, McCormick, J A, Fenton, R A & Loffing, J 2021, ' A five amino acids deletion in NKCC2 of C57BL/6 mice affects analysis of NKCC2 phosphorylation but does not impact kidney function ', Acta Physiologica
, vol. 233, no. 1, e13705 . https://doi.org/10.1111/apha.13705
Acta Physiologica (Oxford, England)

Aim: The phosphorylation level of the furosemide-sensitive Na +-K +-2Cl − cotransporter (NKCC2) in the thick ascending limb (TAL) is used as a surrogate marker for NKCC2 activation and TAL function. However, in mice, analyses of NKCC2 phosphorylati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96c42f9acd9ff97476045a353660fa8e
https://pure.au.dk/portal/da/publications/a-five-amino-acids-deletion-in-nkcc2-of-c57bl6-mice-affects-analysis-of-nkcc2-phosphorylation-but-does-not-impact-kidney-function(3db88d28-8d8c-4c74-967b-c92ddbc167bb).html

Protein Phosphatase 1 Inhibitor-1 Mediates the cAMP-Dependent Stimulation of the Renal NaCl Cotransporter

Autor: Johannes Loffing, Dominique Loffing-Cueni, Nourdine Faresse, Agnieszka Wengi, Sandra Moser, Jan Czogalla, Lena Lindtoft Rosenbaek, Joana Raquel Martins, David Penton, Robert A. Fenton, Fritz Rigendinger

Publikováno v: Penton, D, Moser, S, Wengi, A, Czogalla, J, Rosenbaek, L L, Rigendinger, F, Faresse, N, Martins, J R, Fenton, R A, Loffing-Cueni, D & Loffing, J 2019, ' Protein Phosphatase 1 Inhibitor-1 Mediates the cAMP-Dependent Stimulation of the Renal NaCl Cotransporter ', Journal of the American Society of Nephrology : JASN, vol. 30, no. 5, pp. 737-750 . https://doi.org/10.1681/ASN.2018050540
J Am Soc Nephrol

Background A number of cAMP-elevating hormones stimulate phosphorylation (and hence activity) of the NaCl cotransporter (NCC) in the distal convoluted tubule (DCT). Evidence suggests that protein phosphatase 1 (PP1) and other protein phosphatases mod

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a82c4bcf932864cfd174dce02cd7dc5f
https://pure.au.dk/portal/da/publications/protein-phosphatase-1-inhibitor1-mediates-the-campdependent-stimulation-of-the-renal-nacl-cotransporter(329891ff-07bd-4fff-bbc1-04c084fabe32).html

Extracellular K(+) rapidly controls NaCl cotransporter phosphorylation in the native distal convoluted tubule by Cl(-) -dependent and independent mechanisms

Autor: Johannes Loffing, Dominique Loffing-Cueni, Nina Himmerkus, Olivier Staub, Frank Schweda, David Penton, Jan Czogalla, Monique Carrel, Markus Bleich, Renuga Devi Rajaram, Agnieszka Wengi

Publikováno v: The Journal of Physiology, vol. 594, no. 21, pp. 6319-6331

High dietary potassium (K(+) ) intake dephosphorylates and inactivates the NaCl cotransporter (NCC) in the renal distal convoluted tubule (DCT). Using several ex vivo models, we show that physiological changes in extracellular K(+) , similar to those

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a44f6915985d738e3718e311dff08b6a
https://serval.unil.ch/resource/serval:BIB_2310FFAA834D.P001/REF.pdf

Cordycepin interferes with 3' end formation in yeast independently of its potential to terminate RNA chain elongation

Autor: Bernhard Dichtl, Agnieszka Wengi, Sandra Holbein, Laurence Decourty, Florian M. Freimoser, Alain Jacquier

Publikováno v: RNA (New York, N.Y.). 15(5)

Cordycepin (3′ deoxyadenosine) is a biologically active compound that, when incorporated during RNA synthesis in vitro, provokes chain termination due to the absence of a 3′ hydroxyl moiety. We were interested in the effects mediated by this drug

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65bc5eb43c880ff6cfa3f3eb16552148
https://pubmed.ncbi.nlm.nih.gov/19324962