Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Agnieszka Szyk"'
Autor:
Ewa Szczesna, Elena A. Zehr, Steven W. Cummings, Agnieszka Szyk, Kishore K. Mahalingan, Yan Li, Antonina Roll-Mecak
Publikováno v:
Developmental cell. 57(21)
Microtubules have spatiotemporally complex posttranslational modification patterns. How cells interpret this tubulin modification code is largely unknown. We show that C. elegans katanin, a microtubule severing AAA ATPase mutated in microcephaly and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71aa36e3b4ad6efa0fee713f6fc3577f
https://pubmed.ncbi.nlm.nih.gov/36347241
https://pubmed.ncbi.nlm.nih.gov/36347241
Publikováno v:
Nature structural & molecular biology
The AAA+ ATPase spastin remodels microtubule arrays through severing and its mutation is the most common cause of hereditary spastic paraplegias (HSP). Polyglutamylation of the tubulin C-terminal tail recruits spastin to microtubules and modulates se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37e493d07b93dd860a71952deef9f82f
http://europepmc.org/articles/PMC6761829
http://europepmc.org/articles/PMC6761829
Autor:
Joseph Atherton, Jeff Spector, Agnieszka Szyk, Carolyn A. Moores, Antonina Roll-Mecak, Annapurna Vemu
Publikováno v:
The Journal of Biological Chemistry
Microtubules are polymers that cycle stochastically between polymerization and depolymerization, i.e. they exhibit “dynamic instability.” This behavior is crucial for cell division, motility, and differentiation. Although studies in the last deca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85644727dbf2c3962f8faacf95101cce
https://doi.org/10.1074/jbc.c116.731133
https://doi.org/10.1074/jbc.c116.731133
Publikováno v:
Nature Structural & Molecular Biology. 27:400-400
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6dfdac2c55b5742db74c47f745a35586
https://doi.org/10.1038/s41594-020-0414-8
https://doi.org/10.1038/s41594-020-0414-8
Publikováno v:
Dev Cell
The AAA ATPase katanin severs microtubules. It is critical in cell division, centriole biogenesis, and neuronal morphogenesis. Its mutation causes microcephaly. The microtubule templates katanin hexamerization and activates its ATPase. The structural
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3903763e41e6fd3799af9d22fb70d2cb
https://doi.org/10.1016/j.devcel.2019.10.010
https://doi.org/10.1016/j.devcel.2019.10.010
Autor:
Agnieszka Szyk, Elena A. Zehr, Ewa Szczesna, Antonina Roll-Mecak, Grzegorz Piszczek, Xiaobing Zuo
Publikováno v:
Nature structuralmolecular biology. 24(9)
Microtubule-severing enzymes katanin, spastin and fidgetin are AAA ATPases important for the biogenesis and maintenance of complex microtubule arrays in axons, spindles and cilia. Because of a lack of known 3D structures for these enzymes, their mech
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6193f772b1b56a9cff443aeb368efbfa
https://pubmed.ncbi.nlm.nih.gov/28783150
https://pubmed.ncbi.nlm.nih.gov/28783150
Autor:
Natasza E. Ziolkowska, Agnieszka Szyk, Benjamin Goodman, Vasilisa Kormendi, Antonina Roll-Mecak, Jeff Spector, Alexandra M. Deaconescu, Max L. Valenstein, Nikolaus Grigorieff
Publikováno v:
Cell. 157(6):1405-1415
SummaryAcetylation of α-tubulin Lys40 by tubulin acetyltransferase (TAT) is the only known posttranslational modification in the microtubule lumen. It marks stable microtubules and is required for polarity establishment and directional migration. He
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad7c92994f9e46621f6ec25614ff6673
Publikováno v:
Nature structural & molecular biology
Tubulin tyrosine ligase (TTL) catalyzes the post-translational C-terminal tyrosination of α-tubulin. Tyrosination regulates recruitment of microtubule-interacting proteins. TTL is essential. Its loss causes morphogenic abnormalities and is associate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d58f70a94d46596569bfdf3ed7505ff
https://doi.org/10.1038/nsmb.2148
https://doi.org/10.1038/nsmb.2148
Autor:
Christopher A. Keller, Nicole A. LaRonde-LeBlanc, Agnieszka Szyk, Joe R. Cannon, Seth R. Thomas
Publikováno v:
Nucleic Acids Research
Nucleolar Essential Protein 1 (Nep1) is required for small subunit (SSU) ribosomal RNA (rRNA) maturation and is mutated in Bowen-Conradi Syndrome. Although yeast (Saccharomyces cerevisiae) Nep1 interacts with a consensus sequence found in three regio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe64e061d7956cc9a9f8bb5cd4bb3e36
https://doi.org/10.1093/nar/gkq1131
https://doi.org/10.1093/nar/gkq1131
Autor:
Jun Liu, Junjie Xu, Nicole LaRonde-LeBlanc, Amro Bohsali, Kent L. McDonald, Miao Pan, Joanna Manoranjan, Jennifer Smith, Agnieszka Szyk, Lian-Yong Gao
Publikováno v:
Infection and Immunity. 76:5478-5487
The ESX-1 secretion system plays a critical role in the virulence of M. tuberculosis and M. marinum , but the precise molecular and cellular mechanisms are not clearly defined. Virulent M. marinum is able to escape from the Mycobacterium -containing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcb2181acb1729ecaf52ff5d0c5b658b
https://doi.org/10.1128/iai.00614-08
https://doi.org/10.1128/iai.00614-08