TNF-α synergises with IFN-γ to induce caspase-8-JAK1/2-STAT1-dependent death of intestinal epithelial cells

Autor: Jerzy A. Woznicki, Nisha Saini, Peter Flood, Subhasree Rajaram, Ciaran M. Lee, Panagiota Stamou, Agnieszka Skowyra, Milan Bustamante-Garrido, Karine Regazzoni, Nyree Crawford, Simon S. McDade, Daniel B. Longley, Pedro Aza-Blanc, Fergus Shanahan, Syed A. Zulquernain, Jane McCarthy, Silvia Melgar, Bradford L. McRae, Ken Nally

Publikováno v: Cell Death and Disease, Vol 12, Iss 10, Pp 1-15 (2021)

Abstract Rewiring of host cytokine networks is a key feature of inflammatory bowel diseases (IBD) such as Crohn’s disease (CD). Th1-type cytokines—IFN-γ and TNF-α—occupy critical nodes within these networks and both are associated with disrup

Externí odkaz: https://doaj.org/article/3fd851ad37fa451687518ec09ff3247a

Timed degradation of Mcl-1 controls mitotic cell death

Autor: Paul R. Clarke, Lindsey A. Allan, Agnieszka Skowyra

Publikováno v: Molecular & Cellular Oncology, Vol 5, Iss 6 (2018)

Mitotic arrest can result in cell death through the process of apoptosis. We have shown by live-cell imaging that the ubiquitin-proteasome dependent proteolysis of the apoptotic regulator Mcl-1 under the control of the anaphase-promoting complex or c

Externí odkaz: https://doaj.org/article/725b43a5dc1041cca045f3105b5b461d

DNA sensor-associated type I interferon signaling is increased in ulcerative colitis and induces JAK-dependent inflammatory cell death in colonic organoids

Autor: Peter Flood, Aine Fanning, Jerzy A. Woznicki, Tadhg Crowley, Andrea Christopher, Alessandra Vaccaro, Aileen Houston, Sheila McSweeney, Sarah Ross, Aileen Hogan, Elizabeth Brint, Agnieszka Skowyra, Milan Bustamante, Monica Ambrose, Gerard Moloney, John MacSharry, Marie-Louise Hammarström, Margot Hurley, Christine Fitzgibbons, Eamonn M. M. Quigley, Fergus Shanahan, Syed A. Zulquernain, Jane McCarthy, G. Steven Dodson, Karim Dabbagh, Bradford L. McRae, Silvia Melgar, Ken Nally

Publikováno v: American Journal of Physiology-Gastrointestinal and Liver Physiology. 323:G439-G460

DNA sensor pathways can initiate inflammasome, cell death and type I interferon (IFN) signalling in immune-mediated inflammatory diseases (IMIDs); including type I interferonopathies. We investigated the involvement of these pathways in the pathogene

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad36e069e3c786f0cad7442974473f86
https://doi.org/10.1152/ajpgi.00104.2022

TNF-α synergises with IFN-γ to induce caspase-8-JAK1/2-STAT1-dependent death of intestinal epithelial cells

Autor: Subhasree Rajaram, Simon S. McDade, Daniel B. Longley, Panagiota Stamou, Pedro Aza-Blanc, Ciaran M. Lee, Jerzy A. Woznicki, Karine Regazzoni, Nisha Saini, Nyree Crawford, Kenneth Nally, Fergus Shanahan, Jane McCarthy, Agnieszka Skowyra, Syed Akbar Zulquernain, Milan Bustamante-Garrido, Bradford L McRae, Silvia Melgar, Peter Flood

Publikováno v: Woznicki, J A, Saini, N, Flood, P, Rajaram, S, Lee, C M, Stamou, P, Skowyra, A, Bustamante-Garrido, M, Regazzoni, K, Crawford, N, McDade, S S, Longley, D B, Aza-Blanc, P, Shanahan, F, Zulquernain, S A, McCarthy, J, Melgar, S, McRae, B L & Nally, K 2021, ' TNF-α synergises with IFN-γ to induce caspase-8-JAK1/2-STAT1-dependent death of intestinal epithelial cells ', Cell, Death & Disease, vol. 12, 864 . https://doi.org/10.1038/s41419-021-04151-3
Cell Death & Disease
Cell Death and Disease, Vol 12, Iss 10, Pp 1-15 (2021)

Rewiring of host cytokine networks is a key feature of inflammatory bowel diseases (IBD) such as Crohn’s disease (CD). Th1-type cytokines—IFN-γ and TNF-α—occupy critical nodes within these networks and both are associated with disruption of g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::924890d99a776d6334e0fc589b423a46
https://pure.qub.ac.uk/en/publications/14c63377-1829-45d8-812f-a5990eae4915

The role of serum I-FABP concentration in assessment of small intestine mucosa among HIV-infected patients

Autor: Tomasz Mikuła, Agnieszka Skowyra, Artur Skowyra, Alicja Wiercińska-Drapało, Magdalena M. Suchacz

Publikováno v: European Journal of Inflammation, Vol 13 (2015)

Objectives: The intestinal fatty acid binding protein (I-FABP) is a useful marker in the assessment of damages and inflammation to the small intestinal mucosa. We have investigated the influence of HIV infections and antiretroviral treatment on the s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d830d6501d58ecae3bc08a12e88e72f
https://doaj.org/article/68da8aa9237745ec8c226b1f6407f8a7